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Clot in Biological News

Exploring the molecular origin of blood clot flexibility

How do blood clots maintain that precise balance of stiffness for wound healing and flexibility to go with the flow? Researchers at the University of Pennsylvania School of Medicine and the School of Arts and Sciences have shown that a well-known protein structure acts as a molecular spring, explai...

Combined stem cell-gene therapy approach cures human genetic disease in vitro

...FA), a genetic disorder responsible for a series of hematological abnormalities that impair the body's ability to fight infection, deliver oxygen, and clot blood. Caused by mutations in one of 13 Fanconi anemia (FA) genes, the disease often leads to bone marrow failure, leukemia, and other cancers. Even a...

For old or young dialysis patients, AV fistulas remain pure gold

...ccess," explained Forauer. A significant number of patients with chronic kidney failure receive dialysis using synthetic bridge grafts that tend to clot or malfunction, decreasing reliable access for life-sustaining dialysis and causing considerable morbidity, discomfort and inconvenience for dialysis ...

JCI online early table of contents: Jan. 19, 2009

...?id=37160 HEMATOLOGY: No PKC-alpha protein, no inappropriate blood clot formation The predominant cause of a heart attack is atherothrombosis, where a blood clot (otherwise known as a thrombus) forms in a blood vessel supplying the heart...

Apolipoprotein(a): A natural regulator of inflammation

...lance to plasminogen, the zymogen for plasmin, the primary enzyme for blood clot degradation. In addition to its important role in clot lysis, plasmin is required for leukocyte recruitment in inflammation. While...

Nature study demonstrates that bacterial clotting depends on clustering

...nt the dissemination of the bacteria through the host, it often leads to serious vascular damage due to blocked and injured blood vessels. The key to clot formation is the location of the bacteria, rather than the total number of bacteria or their level of concentration. In other words, for those bacteri...

Where optics meets medicine

...looking at the effect of small strokes in the tiny venules in the brain of rodents. They are using a powerful laser and nonlinear optics to target and clot vessels of the venule system and then monitor the effect on blood flow in upstream capillaries in the brain. They find that blockages in venules can c...

Prosthetic vein valve designed to direct blood flow shows promising pre-clinical results

...lve. Results showed that the new generation of valves remained open with no clot formation after 120 minutes of blood flow, whereas control valves lined wit...e exhibited low flow resistance, strong competency, fatigue-resistance, low clot formation probability and material flexibility, which allowed the researche...

Pivotal national trial uses newest interventional radiology treatment to bust blood clots in legs

...e use of clot-dissolving drugs in combination with clot removal devices to prevent post-thrombotic syndrome in patients with DVT (the formation of a blood clot in a leg vein). PTS, a common irreversible complic...tment paradigm to one that includes interventional clot removal as an essential element of standard DVT ca...

Johns Hopkins scientists discover what drives the development of a fatal form of malaria

... Platelets those tiny, unassuming cells that cause blood to clot and scabs to form when you cut yourself play an important early role in promoting cerebral malaria, an often lethal complication that occurs mostly i...

Skin care: new research into scar-free healing

...ns not just for wound victims but also for people who suffer organ tissue damage through illness or abdominal surgery. When skin is damaged a blood clot forms and cells underneath the wound start to repair the damage, leading to scarring. Scarring is a natural part of tissue repair and is most obvious ...

American Chemical Society's Weekly PressPac -- Nov. 7, 2007

...t of the experiment, eight other compounds from dragon's blood inhibited blood clotting, suggesting their potential use in the prevention of the blood clot responsible for some strokes and most heart attacks, the scientists say. ARTICLE #2 FOR IMMEDIATE RELEASE Anti-Helicobacter pylori and thrombin In...

Does the victim affect snake venom composition?

...Sciences, National University of Singapore. "A new anticoagulant or a hypotensive toxin may help us develop new cardiovascular drugs to block unwanted clot formation or to lower the blood pressure." ...

Bleeding, not inflammation, is major cause of early lung infection death

...f blood flow, or a protective mechanism that prevents unchecked bleeding, all depending on a careful balance. Specifically, the ability of blood to clot is increased by one regulatory pathway of reactions that end with the activation of a protein called plasminogen activator 1 (PAI-1). Against the pro-...

Study offers clues to 'Broken Heart Syndrome'

...'t develop Takotsubo cardiomyopathy," Dr. Regnante said. A surge of stress hormones likely plays a role, he said, but it is also possible that a blood clot temporarily blocks a major artery of the heart, then dissolves before being detected during coronary angiography. The most common symptom of brok...

Jefferson scientists find high glucose before surgery raises risk of dangerous complications

...ss. Deep vein thrombosis occurs in approximately two million Americans each year. Pulmonary embolism (PE), which can cause sudden death, occurs when a clot dislodges from the vein and circulates into the lungs. Each year some 600,000 patients develop PE, which causes or contributes to as many as 200,000 d...

Cell death following blood 'reflow' injury tracked to natural toxin

...ews up and gets rid of PAR. These mouse brains contained twice as much PAR-polymer as those of normal mice. After the researchers induced a blood clot injury like a stroke, the same mice showed a 62 percent increase in the area of brain damage compared to normal littermates. Mice that contain more of...

Scientists work to identify genes that contribute to early heart attack risk

...izes in techniques to uncover the genetic causes of diseases. Atherosclerosis is the development of fatty deposits in arteries that leads to blood clot formation, angina, heart attack and stroke. This process can begin in childhood and early adult life. Doctors have known that genetic factors contribu...

Clot-busting drug helps revive cardiac arrest patients

...ften occurs when the electrical signals that regulate the heart become erratic or irregular because of a heart attack, coronary heart disease, a blood clot in the lungs, or other causes. The heart stops beating and the brain starts to suffer permanent damage within four to six minutes. Death quickly follo...

Natural vitamin E tocotrienol reaches blood at protective levels

...tty acid linoleic acid, which can directly stimulate damaging free radical activity. Fatty acids are related to stroke: They rapidly accumulate when a clot in a vessel stops blood flow to the brain, and play a role in irreversible brain injury. To observe the TCT's effectiveness, rodent neural cells ...

Bubbles go high-tech to fight tumors

...embolotherapy techniques, the so-called cork that doctors use to block the blood flow---called an emboli---is solid. For instance, it could be a blood clot or a gel of some kind. A major difficulty with these approaches is restricting the emboli to the tumor to minimize destruction of surrounding tissue, ...

'Bad' enzymes may wear white hats after stroke

...m is designed to encourage medical students to become physician-scientists. Just after a stroke--a temporary loss of blood to the brain caused by a clot or burst blood vessel--MMPs chew up damaged brain tissue. This increases the risk of swelling and hemorrhage in the brain. Some current stroke treatme...

Promising therapies for haemophilia & heart disease

... Haemophilia is a hereditary blood disease, primarily affecting males, where the blood fails to clot causing potentially life-threatening 'bleeds'. About one in 6000 Australian males is born with haemophilia in severe, moderate or mild form. People wi...

Redesigned protein accelerates blood clotting

...ith factor IX to activate factor X, which creates a burst of thrombin, which in turn generates fibrin, the sticky protein strands that form a web-like clot over damaged tissue. Calcium, a metallic element, must be present for factor VIII to work. Factor VIII has on its surface pocket-like chains of amino ...

Gifts from the sea

...study of vision. MBL scientists have also made significant research breakthroughs related to the horseshoe crab's blood. The crab's amebocyte cells clot in response to bacteria, enabling the development of tools used to test humans, drugs, and sterile environments for toxins. Skate (Raja erinacea): ...

Unusual antibiotics show promise against deadly 'superbugs'

...aves in the body. For example, collagen normally attracts cells to close up a wound and form scar tissue. But this property is not always desirable; a clot can be dangerous inside a blood vessel or at certain injury sites, where scar tissue can interfere with the formation of new nerve connections. Mod...

Modified collagen could yield important medical applications

...aves in the body. For example, collagen normally attracts cells to close up a wound and form scar tissue. But this property is not always desirable; a clot can be dangerous inside a blood vessel or at certain injury sites, where scar tissue can interfere with the formation of new nerve connections. Mod...

Newer imaging techniques may lead to over-treatment

...e been treated in the past and may have done fine. Improved technology is forcing us to face new clinical questions such as whether or not every small clot diagnosed with CT warrants the risks of treatment," he said. ...

U-M team recovers ancient whale in Egyptian desert

...from wounds that won't heal. A wound to the skin allows the entry of oxygen, which initiates cell death. In healthy people, cell death subsides when a clot forms, which allows the healing process to begin. Exposing a diabetic's clot-resistant wound to an oxygen-free environment would speed the healing pro...

Buying Time Through Hibernation on Demand

...from wounds that won't heal. A wound to the skin allows the entry of oxygen, which initiates cell death. In healthy people, cell death subsides when a clot forms, which allows the healing process to begin. Exposing a diabetic's clot-resistant wound to an oxygen-free environment would speed the healing pro...
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