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Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells

JACKSONVILLE, Fla. Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer that spreads elsewhere in the body, known as metastasi...

Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family

JACKSONVILLE, Fla. In 2005, a woman who had trouble sleeping asked Siong-Chi Lin, M.D., for help. Dr. Lin, a sleep disorders specialist at the Mayo Clinic campus in Florida, diagnosed restless legs syndrome. This common neurologic disorder interrupts sleep because of unpleasant sensations in the...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

SCOTTSDALE, Ariz. Jan. 29, 2008 TGen Clinical Research Services (TCRS) at Scottsdale Healthcare and Mayo Clinic are testing a new drug that may offer broad potential to treat solid tumors. Clinical trials of the drug TH-302 are being conducted at TGen Clinical Research Services at Scottsdale...

TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims

SCOTTSDALE, Ariz. Dec. 19, 2008 The Translational Genomics Research Institute (TGen), Scottsdale Healthcare and Mayo Clinic are testing a new drug that could help cancer patients by stimulating the immune system. Clinical trials of the drug VTX-2337 are being conducted at TGen Clinical Resear...

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

SAN ANTONIO - Findings from a new study have prompted Mayo Clinic researchers to recommend CYP2D6 gene testing for postmenopausal women about to begin tamoxifen therapy. This data confirms that women with an inherited deficiency in the CYP2D6 gene, which is important for the metabolism of tamoxife...

Building bridges between the clinic and the laboratory

Cambridge, UK, 04 August 2008 - Disease Models & Mechanisms ( DMM ) is the first journal to focus on translational research and the use of model organisms to advance human health. Published by the Company of Biologists, DMM is a highly anticipated biomedical research journal which officially ...

Mayo Clinic Proceedings January tip sheet

ROCHESTER, Minn. -- Featured articles from the January issue of Mayo Clinic Proceedings include the effects of antioxidant supplements on cancer, guidelines for workplace drug screening and the safety and effectiveness of nasal spray flu vaccine. Mayo Researchers Examine the Effect of Antioxi...

Mayo Clinic study: Ossur's collars superior in immobilization and reduction of pressure

December 12, 2007 (Aliso Viejo, California) Ossur, an emerging leader in the non-invasive orthopaedics market following several acquisitions and a period of integration, is pleased to announce that the Journal of Trauma has published the long-awaited results of a two year cervical collar study pe...

Cleveland Clinic leading clinical program to improve early-stage lung cancer detection

Chicago, November 26, 2007 Cleveland Clinic and Riverain Medical today announced the establishment of the first study in an ongoing program to determine whether chest X-ray CAD (computer-aided detection) can improve practical early detection of lung cancer. The program is designed to determine w...

Sharper image: UH optometrist establishes sports vision clinic

The standard eye chart only covers letters and numbers, but athletes need above average vision to track balls hurtling toward them at alarming speeds. To test those special skills, a University of Houston optometrist has founded the Sports Vision Performance Center, a facility where athletes perfo...

Mayo Clinic study suggests that a central nervous system viral infection can lead to memory deficits

In one of the first known laboratory studies that explores memory deficits associated with a viral infection of the central nervous system, Mayo Clinic researchers have evidence that this infection can lead to memory loss late in life. The study, which was conducted in animal models, suggests that ...

Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug

A unique Mayo Clinic collaboration has revived the healing wisdom of Pacific Island cultures by testing a therapeutic plant extract described in a 17th century Dutch herbal text for its anti-bacterial properties. Early results show that extracts from the Atun tree effectively control bacteria that ...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

Mayo Clinic Cancer Center has opened a new clinical study using a vaccine strain of the measles virus to attack recurrent glioblastoma multiforme, a largely untreatable brain tumor. This is the second of several pending molecular medicine studies in patients using measles to kill cancer. "We are...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

Mayo Clinic researchers report that the expression of two novel genes within the tumors of women with early stage breast cancer may allow identification of women who are and are not at risk for early relapse or cancer-related death. Results of the study are published in the April 1 issue of Clinic...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

Mayo Clinic researchers have uncovered a new cellular secret that may explain how certain cancers move and spread -- a feature of cancers that makes treatment especially difficult. If the mechanism that drives cancer movement -- also called metastasis -- can be understood well enough to manipulate ...

Mayo Clinic researchers challenge sepsis theory

A Mayo Clinic research team has challenged the accepted theory on the cause of sepsis -- a condition in which the body's cells generate fever, shock and often death. Sepsis is thought to occur when poisons from bacterial infection interfere with the cells. The Mayo researchers challenge that long...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin. Once amplified, even low-level damage signals become strong enough to activate the cell's natural repair processes while the injury is most tractable to repai...

Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot

Mayo Clinic researchers have found that the cause of chronic sinus infections lies in the nasal mucus -- the snot -- not in the nasal and sinus tissue targeted by standard treatment. The findings will be published in the August issue of Journal of Allergy and Clinical Immunology and are available ...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

An international team of Mayo Clinic-led researchers is first to devise a system that consistently converts the measles virus into a therapeutic killer that hunts down and destroys cancer cells -- and cancer cells only. Their research findings appear as an advanced electronic article of Nature Biot...

Stem cell research: From molecular physiology to therapeutic applications

...eutics. Given the early indications for success, we hope to see promising remedies for the many current uncurable diseases being made available in the clinic over the coming years. ...

Test helps in fight against lung infections and for treating other life-threatening infections

...rta Hospital laboratory, under the direction of Dr. Robert Rennie, Site Chief, Laboratory Medicine and Dr. Neil Brown, Director, Adult Cystic Fibrosis clinic conducted the clinical research from 2007 to 2009. The clinical research involved 14 patients with cystic fibrosis at the University of Alberta ho...

Bioterrorism and disaster preparedness explored in special issue of Medical Decision Making

...t of a Mass Influenza and Pneumococcal Vaccination clinic via Computer Simulation" This research set out to determine the best way a clinic could vaccinate as many as 15,000 clients in 17 ho...The researchers found that it was possible for the clinic to reach its target and that using a computer simu...

SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center

...its tools in a hypothesis-driven paradigm to accelerate drug discovery efforts of its collaborators and clients, having placed multiple compounds into clinic with significantly reduced numbers of compounds screened and synthesized and with significantly shortened time frames. ...

Systems biology recommended as a clinical approach to cancer

..., especially as mathematical modelers, biologists, and clinicians continue working together. Through these transdisciplinary efforts, the needs of the clinic can directly impact work in the laboratory." According to the researchers, before the functional differences between a cancer cell and a normal cel...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

...ut what causes this group of diseases," he said. "We look forward to the day when we can use a combination of genetic and gene expression tests in the clinic to help us better diagnose and treat childhood arthritis." ...

Ovarian transplantation: First baby is born after a new technique

...een frozen because of cancer treatment. He said that his team's technique worked to restore ovarian function quickly and already one patient from his clinic had had a baby and another had become pregnant. "On June 22, a baby girl was born to a mother who had been menopausal for two years as a result of ...

CWRU receives $5 million from Ohio Third Frontier Commission

... CLEVELAND June 25, 2009 The Center for Stem Cell & Regenerative Medicine (CSCRM), comprised of Case Western Reserve University (CWRU), Cleveland clinic (CC), University Hospitals (UH), and Athersys, Inc. has received $5 million from Ohio's Third Frontier Commission under the Research Commercialization...

New nanoparticles could revolutionize therapeutic drug discovery

...ngs, BBSRC Chief Executive Professor Doug Kell, said: "The attrition rate in developing new drugs is phenomenal. Only a tiny fraction make it into the clinic to benefit patients. Research such as this that can help to increase the number of potential targets will mean a larger pipeline for scientists to dev...

Engineering innovative solutions for 21st century medicine

...ll conduct world-class clinical trials to show the benefit of new discoveries in imaging technology that the centre will produce. I see patients in my clinic every day, so I have a very clear understanding of what they need to make their lives better. Medical imaging has the capacity to give my patients acc...

Stem cell surprise for tissue regeneration

... Carnegie's Department of Embryology. "This work illustrates the importance of carrying out basic research using animal models before rushing into the clinic with half-baked therapies." ...

Mouse model provides clues to human language development

... journal Cell . Scientists of the German Mouse clinic at Helmholtz Zentrum Mnchen have generated and ana...w. The Helmholtz scientists in the German Mouse clinic conduct comprehensive analyses to elucidate which ...ve research approach like that of the German Mouse clinic is so crucial to ensure that relevant gene functi...

Scientists explain how 'death receptors' designed to kill our cells may make them stronger

... of The FASEB Journal ( http://www.fasebj.org ), scientists from the Mayo clinic explain how cell receptors (called "death receptors") used by the body to s... M.D., Chair of the Division of Gastroenterology and Hepatology at the Mayo clinic in Rochester, Minn., and one of the scientists involved in the work. In ...

Study shows CGM devices also benefit people with type 1 diabetes

...ears-old at 10 sites, including the Atlanta Diabetes Associates, the Joslin Diabetes Center, Kaiser Permanente Southern California, Nemours Children's clinic Jacksonville, FL, the Lucile Packard Children's Hospital at Stanford University, the Barbara Davis Center for Childhood Diabetes at the University of...

Using 'dominance' to explain dog behavior is old hat

... dogs. It also leads to the use of coercive training techniques, which compromise welfare, and actually cause problem behaviours. "In our referral clinic we very often see dogs which have learnt to show aggression to avoid anticipated punishment. Owners are often horrified when we explain that their dog...

UT nanomedicine project to be tested in space

...xperiment will allow us to refine our technologies for the release of a drug at the right time and to the right place in the body, and to bring to the clinic the vision of personalized medicine." The competition was sponsored by The Heinlein Prize Trust, SpaceX (Space Exploration Technologies) and the Ri...

Early detection of lung cancer: New data presented at multidisciplinary meeting

...le. In another abstract, UK scientists report that a new approach to diagnosis that ensures a patient has had a chest CT scan before they attend a clinic has the potential to reduce the time between their first abnormal chest X-ray and final diagnosis. Also during the conference, Greek investigators ...

Diminuendo -- New mouse model for understanding cause of progressive hearing loss

... this mouse model and who is scientific -technical head of the German Mouse clinic at Helmholtz Zentrum Mnchen. The new mouse model is called diminuendo, ...s like these, Martin Hrab de Angelis and his colleagues in the German Mouse clinic can thus identify mutants that develop diseases similar to human diseases. ...

Ultrasound imaging now possible with a smartphone

...cy while minimizing side effects. "The idea is that caregivers, who otherwise have to transport a young person often wheelchair bound to a hospital or clinic on a regular basis for examination, can be trained to do ultrasound to track muscle condition," Zar said. "This could lower the dosage to the least e...

Allscripts Integrates Electronic Health Records with Innovative Patient Kiosk

...s time and money," said Josh Napua, Vice President, Healthcare Solution Group, Fujitsu Computer Products of America, Inc. "We believe that Springfield clinic and Medical Faculty Associates can be examples to the healthcare industry of how delivery of patient services can be more streamlined and secure, prov...

'First aid' for brain cells comes from blood

...n. For the first time, scientists at the Neurology clinic at Heidelberg University Hospital have shown that ...y fatal or causes severe disability. The Neurology clinic in Heidelberg under the direction of its medical d...Roland Veltkamp, senior physician at the Neurology clinic of Heidelberg University Hospital has now shown in...
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