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Cardiac in Biological News

Researchers identify a molecule that increases the risk of cardiac insufficiency

This release is available in Spanish . A team of scientists from the Center for Applied Medical Research (CIMA) of the University of Navarra has identified a key enzyme in the development of cardiac insufficiency. This enzyme is involved in the accumulation of fibrous tissues in the heart...

Common gene variants influence risk factor for sudden cardiac death

A new study has identified several common genetic variants related to a risk factor for sudden cardiac death. The report receiving early online release in the journal Nature Genetics identifies variants in genes, some known and some newly discovered, that influence the QT interval measured on th...

Genetic risk factors identified for sudden cardiac death

Building on these findings, the Helmholtz scientists and their clinical partners want to obtain further insights into the pathogenesic mechanisms of the disease and gain perspectives for early diagnosis and therapy. The results of the genome-wide study have been published online in the journal Na...

Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death

One minute, he's a strapping 40-year-old with an enviable cholesterol level, working out on his treadmill. The next, he's dead. That an abnormality in his heart's electrical system had managed to stay on the Q.T. until it proved lethal is characteristic of sudden cardiac death, which an...

Ten genes identified in connection with sudden cardiac death

ANN ARBOR, Mich.---You're sitting at your desk and suddenly your heart is beating in overdrive or worse, lurching along like a car on fumes. It is a shocking, uncomfortable and frightening sensation. Irregular heart rhythms are a common cause of sudden cardiac death or SCD, a condition that ac...

Sudden cardiac death without recognizable cause

In about 10% of cases, sudden cardiac death (SCD) in young people is due to a cardiac gene defect. This was the conclusion drawn by Silke Kauferstein of the Department of Forensic Medicine of the Johann Wolfgang Goethe University, Frankfurt, and her coauthors in the current Deutsches rzteblatt In...

Damage inflicted during cardiac attacks more widespread, MSU researchers find

EAST LANSING, Mich. Cholesterol crystals released in the bloodstream during a cardiac attack or stroke can damage artery linings much further away from the site of the attack, leaving survivors at greater risk than previously thought. George Abela, a physician in Michigan State University's Co...

New mechanism for cardiac arrhythmia discovered

It has long been thought that virus infections can cause cardiac arrhythmia. But why has not been understood. Ulrike Lisewski, Dr. Yu Shi, Michael Radke and Professor Michael Gotthardt of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now discovered the molecular me...

Syntermed licenses Emory ERTb software for enhanced cardiac imaging

A comprehensive software package designed to significantly improve the quality and accessibility of nuclear cardiology images has been licensed by Emory University to Syntermed, an Atlanta-based nuclear medicine imaging and informatics software company. The software, called the Emory Reconstructi...

Cardiac cell transplant studies show promise in cardiac tissue repair

Tampa, Fla. (Sep. 3rd, 2008) Two studies published in the current issue of CELL TRANSPLANTATION (17:6) examine the efficacy of transplanting bone marrow cells (BMCs) for the repair of heart tissue. The first study found that implanting adult cardiomyocytes (heart muscle cells) in combination...

A home early warning system for cardiac patients

Heart disease is the number one cause of death in Europe and early diagnosis is essential to save lives. Monitoring the heart's rhythm and electrical activity in real time using an electrocardiogram (ECG) provides vital information about abnormalities and gives clues to the nature of a problem. S...

CU-Boulder, biotech firm team up on python project in search for human cardiac therapeutics

The University of Colorado at Boulder is teaming up with a Boulder biotechnology company to use pythons, which dramatically increase their heart size for a short time after swallowing prey, as models for new therapeutics to treat cardiac diseases. Hiberna Corp., a Boulder-based company developi...

Implanting embryonic cardiac cells prevents arrhythmias

When researchers at Cornell, the University of Bonn and the University of Pittsburgh transplanted living embryonic heart cells into cardiac tissue of mice that had suffered heart attacks, the mice became resistant to cardiac arrhythmias, thereby avoiding one of the most dangerous and fatal consequ...

Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery

Charles Bridges, MD, ScD, Associate Professor of Surgery at the University of Pennsylvania Medical Center and Chief of Cardiothoracic Surgery, Pennsylvania Hospital, has been awarded a $3 million grant from the National Heart, Lung and Blood Institute for his work in molecular cardiac surgery: a u...

University of Pittsburgh cardiologists identify new cardiac arrest gene

PITTSBURGH, Oct. 31 Researchers at the University of Pittsburgh School of Medicine have identified a new gene responsible for a rare, inherited form of sudden cardiac arrest, known as Brugada syndrome. With the identification of this new gene, the researchers hope this will shed light on the more...

Twin studies reveal genetic components leading to cardiac and kidney disease

Daniel O’Connor, M.D., Professor of Medicine and Pharmacology at the University of California, San Diego (UCSD) School of Medicine has studied about 265 twin pairs over the past few years, which has led him to some surprising discoveries. "By studying many traits and genes, we have started to put...

Clot-busting drug helps revive cardiac arrest patients

Using a "clot buster" drug normally reserved for treating patients during a heart attack, emergency room doctors were able to double the number of patients who could be revived from cardiac arrest. This sudden loss of heart function occurs in more than 260,000 people a year nationwide ?and at least...

Even a little cooling helps after cardiac arrest

Is that salt marsh healthy? To answer this, Sea Grant biologists are cracking open common marsh snails and counting parasitic worms. Their claim: the more parasites, the healthier the marsh. While the parasite hypothesis may conflict with conventional ideas about infectious disease and human heal...

U of MN uses robotic surgery techniques in cardiac cell therapy research

Researchers at the University of Minnesota were successful in using robotic surgery to deliver stem cell treatment to damaged heart tissue in pigs. Using minimally invasive robotic surgery equipment, researchers injected the stem cells into the damaged hearts. The cells were "labeled" with iron ...

Man-made heart tissue improves cardiac performance

Researchers have developed a method to engineer blood vessels within the tissue of previously engineered heart muscle. Trials have resulted in significant improvement in heart function. The study is published in the journal Artificial Organs. With heart disorders affecting individuals globall...

Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack

A drug has been shown to provide some protection to the heart from injury even if given as much as 24 hours after a heart attack, Jefferson Medical College researchers report. Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical ...

Mouse gene shows new mechanism behind cardiac infarction in man

A gene that, in different variants, increases or decreases the level of atherosclerosis has been identified in mice. The corresponding human gene has been shown to play a role in the development of myocardial infarction. The results of the study is published this week on Nature Genetics Online. ...

Duke engineers develop new 3-D cardiac imaging probe

Biomedical engineers at Duke University's Pratt School of Engineering have created a new three-dimensional ultrasound cardiac imaging probe. Inserted inside the esophagus, the probe creates a picture of the whole heart in the time it takes for current ultrasound technology to image a single heart c...

NIH stimulus funding supports Emory biomedical scientists

...ammatory molecules that contribute to pulmonary fibrosis. Mechanisms of cardiac fibrosis: NADPH oxidases are enzymes that create reactive oxygen species, a...rron Deshazer is working with Emory cardiologist John Oshinski to study how cardiac imaging can help doctors decide who could benefit from a pacemaker. Deshaze...

'Show me the money!' MDA greenlights grants

...disease. "The longer patients with DMD live, the greater the risk of cardiac complications. In this study, we hope to improve cardiac care by establishing the best medication regimen and to look at the best ti...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

...nd described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. ...ve on heart development. Zebrafish treated with BCI had a greater number of cardiac progenitor cells and, ultimately, larger hearts, Dr. Tsang said. Unrave...

Enzyme doesn't act alone in atrial fibrillation

...7, 2009) An overactive enzyme is behind a leaky calcium channel that plays a role in the development of atrial fibrillation, which is the most common cardiac arrhythmia that is responsible for a third of all strokes. However, it doesn't act alone, say researchers at Baylor College of Medicine. The findings ...

Trans fats hinder multiple steps in blood flow regulation pathways

...e in the U.S. die from coronary heart disease before reaching a hospital or while in an emergency room. Most of those deaths are the result of sudden cardiac arrest, the Heart Association reports. "This is the first time that trans fatty acids have been shown to interfere with yet another part of the blo...

Promising device snags young inventors coveted spot at IShow

...ors." The device, known as the BlueScale, simultaneously records a variety of patient information, including weight, heart rate, blood pressure and cardiac output, in a mere 10 seconds. When combined, those daily measurements offer a good picture of the health of the patient's cardiovascular system and ca...

Common chemotherapy drug triggers fatal allergic reactions

...as been associated with hypersensitivity reactions, with responses ranging from mild skin conditions to more severe effects, including anaphylaxis and cardiac collapse. Current U.S. product labeling for Cremophor containing paclitaxel includes a black-box warning alerting physicians and patients of potential...

NIH funds work at WPI on regenerating heart tissue and preventing urinary tract infections

...s), which come from the bone marrow, to regenerate cardiac tissue, thereby helping a damaged heart beat more ...tively. Heart attacks cause significant scaring of cardiac tissue, which in turn prevents the scarred area of...e injected into a damaged heart, they help improve cardiac function. Working with WPI colleagues George Pins,...

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

... marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart failure. Using an anim... myocytes, or heart cells, by two-fold and reduced cardiac tissue injury by 60 percent. The therapy also im...ed MSCs and host tissues, culminating in effective cardiac repair for the failing heart." The paper reporti...

New therapy substitutes missing protein in those with muscular dystrophy

...rst to establish the efficacy and feasibility of the TAT-utrophin-based protein as a viable therapy for the treatment of muscular dystrophy as well as cardiac muscle diseases caused by loss of dystrophin. The research is published in the May 26, 2009 issue of PLoS Medicine . "This unique approach can...

Comprehensive cardiogenetic testing for families of sudden unexplained death victims can save lives

...amily medical history and a resting ECG. A second cardiac autopsy of the SUD victim was undertaken if tissue...ives and try to prevent their succumbing to sudden cardiac death. "The scale of heart disease that we foun... identification of more families at risk of sudden cardiac death, in which preventive measures then can be ta...

Genetic factors may predict depression in heart disease patients

...arge-scale genetic study of depressive symptoms in cardiac patients. "Depression can significantly impact ... patients and can increase the risk for additional cardiac events or even death," said lead author Jeanne M. ...unt for the greater prevalence of depression among cardiac patients, including the stress of a poor prognosis...

Bull's-eye electrode helps interpret thoughts, deliver stimulus to aid paralyzed, epileptic patients

...tions from other sources and allow us to focus in on exactly the signal we're most interested in." Initially used for a more accurate detection of cardiac signals, Besio began to test its usefulness in detecting brain waves in an effort to help his brother who had become paralyzed in an automobile accide...

Flow of potassium into cells implicated in schizophrenia

... help correct disorganized brain activity in schizophrenia without risk of cardiac side effects associated with some existing antipsychotic medications. Scien...orm potentially opens the way to development of new treatments free of such cardiac side-effects. Dramatically changed activity in rodent brains toward a ne...

Older men more likely than women to die after pneumonia

...4.9 years, 1,136 of whom were men. The men were sicker on admission, more likely to be smokers, and had at least one chronic health condition, such as cardiac disease or cancer. Severe sepsis occurred in 588 (31 percent) subjects. Of these, about half had severe sepsis on their first day of hospitalization. ...

Heart attacks: The tipping point

...n Heart by Email Dr. Zlochiver's research will no doubt alter the way cardiac arrest is diagnosed and treated. "If we get an image from an MRI or CT from... For example, physicians will be able to locally ablate or release drugs in cardiac areas that are especially susceptible to fibrillation." In the future, ...

Gladstone scientists identify key factors in heart cell creation

... combination of factors has been found to activate cardiac differentiation in mammalian cells or tissues. ... complexes have severe heart defects and defective cardiac differentiation. These observations prompted us to...uscle, heart, and other tissues, specifically into cardiac muscle cells (cardiomyocytes) that beat rhythmical...
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