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Cancers in Biological News

Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target

CLEVELAND: Research out of the Ireland Cancer Center of University Hospitals Case Medical Center has found that the vast majority of triple negative breast cancers express the MUC-1 target. This first-of-its-kind finding, presented today at the San Antonio Breast Cancer Symposium, has paved the w...

Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening

PHILADELPHIA A study published in the journal Clinical Cancer Research, a journal of the American Association for Cancer Research, validates a non-invasive screening method with future potential for detection of human papillomavirus (HPV)-positive head and neck cancers. In the study, resear...

Breast cancers behave differently before and after the age of 70

Berlin, Germany: Researchers in Belgium have discovered that increasing age affects the way breast cancer behaves. As women approach the age of 70, they become less likely to be diagnosed with aggressive tumours that have spread to the lymph nodes. But after 70, the cancer is increasingly likely t...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

Philadelphia (July 27, 2009) DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it may be an ideal target for future anti-...

Possible drug target found for one of the most aggressive breast cancers

Grand Rapids, Mich. (July 8, 2009) Van Andel Research Institute (VARI) investigators have identified a gene that could be an important therapeutic target in the treatment of the most aggressive forms of breast cancer. Currently, patients with these cancers have few treatment options. "Breast...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approxima...

NC State researchers find soy may aid in treating canine cancers

Researchers at North Carolina State University are looking to soy as a way to make traditional canine cancer therapy more effective, less stressful for the dog and less costly for the owners. Dr. Steven Suter, assistant professor of oncology, and NC State colleagues studied genistein - a molecu...

On the trail of a targeted therapy for blood cancers

INDIANAPOLIS Investigators from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine are focusing on a family of blood proteins that they hope holds a key to decreasing the toxic effects of chemotherapy in children and adults. Their findings may one d...

H. Pylori bacteria may help prevent some esophageal cancers

PHILADELPHIA Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live in the stomachs of humans. The review, published in t...

Researchers identify cancer-causing gene in many colon cancers

BOSTON--Demonstrating that despite the large number of cancer-causing genes already identified, many more remain to be found, scientists at Dana-Farber Cancer Institute have linked a previously unsuspected gene, CDK8, to colon cancer. The discovery of CDK8's role in cancer was made possible by ...

Dense tissue promotes aggressive cancers

New research may explain why breast cancer tends to be more aggressive in women with denser breast tissue. Breast cancer cells grown in dense, rigid surroundings step up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 issue of Current Biology . The...

New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers

The first oral, broad-spectrum angiogenesis inhibitor, specially formulated through nanotechnology, shows promising anticancer results in mice, report researchers from Children's Hospital Boston. Findings were published online on June 29 by the journal Nature Biotechnology . Because it is nont...

AACR annual meeting showcases developments in understanding and targeting cancers

SAN DIEGO -- Cutting-edge breakthroughs in molecular targeting, translational cancer research and cancer prevention will take center stage when more than 17,000 scientists from around the world gather at the San Diego Convention Center April 12-16 for the 2008 Annual Meeting of the American Associ...

Curry-derived molecules might be too spicy for colorectal cancers

SINGAPORE -- Curcumin, the yellowish component of turmeric that gives curry its flavor, has long been noted for its potential anti-cancer properties. Researchers from Tohoku University in Sendai, Japan, report on an apparent improvement upon nature: two molecular analogues of curcumin that demon...

Genome update defines landscape of breast and colon cancers

One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers. ...

Dealing deadly cancers a knockout punch

New scientific evidence is helping to build a compelling case for oncolytic viruses as a first-line and adjunctive treatment for many cancers. Reovirus, a non-pathogenic virus under development at Calgary, Alberta-based Oncolytics Biotech, has shown powerful anti-cancer activity against cultur...

Light-based probe 'sees' early cancers in first tests on human tissue

In its first laboratory tests on human tissue, a light-based probe built by researchers at Duke University's Pratt School of Engineering almost instantly detected the earliest signs of cancer in cells that line internal organs. If the preliminary success of the "optical biopsy" is confirmed throu...

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

Researchers have devised a new method to detect a spectrum of known gene mutations in a variety of cancer genes that they say is both sensitive and cost-effective. They say that if validated, this method of genotyping might ultimately be used in "real time" to match patients to available targeted t...

Elasticity imaging identifies cancers and reduces breast biopsies

A new ultrasound technique allows radiologists to accurately distinguish benign from malignant breast lesions. Using elasticity imaging, researchers correctly identified both cancerous and harmless lesions in nearly all of the cases studied. The findings were presented today at the annual meeting o...

Scientists tie several cancers to common 'oncogene engine'

Researchers at Dana-Farber Cancer Institute report that a common "oncogene engine" ?a small family of malfunctioning cell growth switches ?drives several seemingly unrelated, lethal forms of cancer, including malignant melanoma. The finding suggests that it may be possible to attack these different...

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

Earlier this year, researchers at the University of Pennsylvania School of Medicine identified a link between a critical cancer pathway and an Epstein-Barr Virus (EBV) protein known to be expressed in a number of EBV-associated cancers. Their findings demonstrated a new mechanism by which EBV can t...

Most common lung cancers may begin in newly discovered cells

The most common form of lung cancer may begin in a group of newly isolated lung stem cells, according to researchers from the Howard Hughes Medical Institute. Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two...

Major breakthrough in the treatment of cancers and infectious diseases

Montreal researchers identify new anti-cancer, anti-infection response control mechanism Dr. André Veillette, a researcher at the Institut de recherches cliniques de Montréal (IRCM), and his team will publish in the upcoming issue of the prestigious journal Nature Immunology of Nature Publishing...

Study reveals dramatic difference between breast cancers in US and Africa

A study comparing, for the first time, breast cancers from Nigeria, Senegal and North America has found that women of African ancestry are more likely to be diagnosed with a more virulent form of the disease than women of European ancestry. Researchers from the University of Chicago, working wit...

Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

In people infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy (HAART) may prevent most excess cases of Kaposi sarcoma and non-Hodgkin lymphoma, according to a new study in the March 16 issue of the Journal of the National Cancer Institute. Studies of people with...

Towards precise classification of cancers based on robust gene functional expression profiles

Chemists say they have identified a gene that appears to play a key role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disease that affects about one million people in the U.S. and is on the rise worldwide. They described their findings, which they s...

Moving to the US increases cancer risk for Hispanics

...tion groups have higher incidence rates of certain cancers and worse cancer outcomes if they live in the Unit... Pinheiro and colleagues evaluated the kinds of cancers occurring in each Hispanic population group and co...ans seemed to acquire higher risk for diet-related cancers relatively quickly. Furthermore, Cuban males ha...

The way you eat may affect your risk for breast cancer

...ontreal. This study "contributes to accumulating evidence that caloric restriction acts by altering hormone levels rather than by directly starving cancers of energy. In particular, lower levels of insulin are associated with reduced food intake, and this may be protective," said Pollak, who is also an ed...

La Jolla Institute discovers novel tumor suppressor

...oup of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood. "PLC-beta 3 is an enzyme, but the function we found was a completely different function that no one knew it had -- as a tumor suppre...

Stem cell 'daughters' lead to breast cancer

...d Eliza Hall Institute scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations in the gene BRCA1. BRCA1 gene mutations are found in 10-20 per cent of women with hereditary breast cancer....

Parasites ready to jump

...central role. "Transposons are genomic parasites, so to speak", says Frstemann. "If they are allowed to proliferate, the genome can become unstable or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely how it works."...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...ears finding PTN's receptor, which is ALK. They have since characterized the relationship between PTN and ALK, reporting in this study that many brain cancers overexpress PTN and ALK very similar to the developing brain. "When the brain is developing, it needs to constantly remodel itself," he says. "Gliobla...

UCSF researchers identify new drug target for Kaposi's sarcoma

... then deemed undruggable, more attractive. Protein-protein interactions have been researched as drug targets against a range of diseases, from certain cancers to neurodegenerative diseases. This advance could enable researchers to reconsider those targets, he said. ...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

...ective treatments for advanced ovarian cancer that has recurred after surgery and primary chemotherapy. Therefore, the majority of treated early stage cancers will relapse. "This report is definitely a reason to hope. We now have a potential new therapy for the treatment of advanced ovarian cancer that h...

A crystal ball for brain cancer?

... UCLA doctor prescribed the off-label use of Avastin, a drug shown to quell cancers in the breast, colon and lung. One month later, McNabb's tumors had sh... is an expensive drug, yet only 50 percent of patients with recurring brain cancers respond to it," said lead author Dr. Whitney Pope, assistant professor of r...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...hat the development of AML may require fewer genetic alterations than other cancers and that a very limited number of biological processes may need to be alter...s of AML, but there are very few lesions in total. That is surprising. Most cancers have lots of alterations," he explained. AML accounts for about 20 perce...

Study reveals a reprogrammed role for the androgen receptor

...n receptor directs a distinct gene pathway in androgen-independent prostate cancers may lead to the identification of genes in that pathway that can be targeted by future therapies." Prostate cancers whose growth is fed by androgen are commonly treated with androgen-blocking...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Geor...er study at MCG and other centers for a variety of cancers and blood disorders. Because tumor cells that res...fluids, non-invasive screening for a wide range of cancers could result be another result of this initiative,...

Grant supports LSUHSC research on how like cell receptor systems determine very different functions

...nderstanding this novel mechanism might be important in treating conditions that are dependent upon specific growth factor receptors, like some breast cancers in which the EGF receptor family drives growth and survival. "Our studies might provide insight into how specific functions of a pathway might be t...

New drug may reduce heart attack damage

..." he said. Professor Khachigian said other, independent trials of Dz13 were about to get underway to target c-Jun in a range of diseases, from skin cancers to eye disorders. "Our discovery means that heart attack patients may also benefit from Dz13. "These drugs are relatively easy to make and de...
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