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Cracking the olfactory code in bees

In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimental test intended to identify early ovarian cancer from a...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

A scientist at the Marine BiologicalLaboratory (MBL) has published the results of an EPA-funded clam embryostudy that supports her hypothesis that, when combined, the pollutantsbromoform, chloroform, and tetrachloroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator in nervecell development. While scientists have previously studied the effectsof these...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

In a stunning example of evolution at work, scientists have now found that changes in a single gene can produce major changes in the skeletal armor of fish living in the wild. "Our motivation is to try to understa...

Development of portable infectious disease detector

A portable device similar to today's homepregnancy tests that can quickly detect the presence of infectiousdiseases, including HIV-AIDS and measles, as well as biological agentssuch as ricin and anthrax, is the object of a new jointuniversity/industry research project.Vanderbilt University's Institute for Integrative Biosystems Researchand Education (VIIBRE) and Pria Diagnostics LLC, a priv...

WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas

The World Health Organization (WHO) warned about increased risk of vector-borne diseases such as malaria and dengue fever across tsunami-affected areas in Southeast Asia. Nearly four weeks after the disaster struck the region on 26 December, the organization is strengthening its disease surveillance, stagnant water conditions creating conditions for mosquito vectors to multiply to sufficient leve...

Doctors closer to using gene analysis to help trauma patients

A genetic tool with the potential to identify which trauma and burn patients are most likely to become seriously ill has worked consistently in a wide range of experimental clinical settings ?an important hurdle to overcome before the method is routinely used in emergency rooms and intensive care units. In a report published today (March 7) in the Proceedings of the National Academy of Sc...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

University of North Carolina at Chapel Hill researchers have made a discovery that may have implications for the treatment of liver-based genetic defects such as hemophilia A and B in humans. Mouse embryonic stem cells treated in culture with a growth factor and then injected into the liver reverse a form of hemophilia in mice analogous to hemophilia B in humans, the new study shows. A re...

Survey reveals women and doctors aren't talking about HPV

Eighty-eight percent of women rely on their healthcare providers to learn about gynecological issues, yet only 19 percent said their doctor has talked to them about cervical cancer and its cause - the human papillomavirus (HPV) - according to a new survey released by the Association of Reproductive Health Professionals (ARHP). HPV is extremely common, affecting an estimated 80 percent of sexually...

The first impact factor for PLoS Biology ?13.9

The open-access journal PLoS Biology has been assessed by Thomson ISI to have an impact factor of 13.9*, which places PLoS Biology among the most highly cited journals in the life sciences. This is an outstanding statistic for a journal less than two years old, from a new publisher promoting a new business model that supports open access to the scientific and medical literature. An impact...

Open Access journals get impressive impact factors

Impressive impact factors prove that BioMed Central's Open Access journals are high quality and widely read and cited. Journals published by BioMed Central have again received impact factors that compare well with equivalent subscription titles, it was announced today, with five titles in the top five of their specialty. The high impact factors for these journals affirm that they are respected by...

New defibrillator signals doctor of patient's irregular heartbeat or device malfunction

Loyola first in U.S. to implant new FDA-approved device In a major advance for heart patients, Loyola University Health System is the first hospital in the U.S. to implant into a patient a new FDA-approved defibrillator which automatically signals the doctor via wireless satellite transmission if the patient's heart beats abnormally or if the device malfunctions, e.g., battery failure.</p...

Novel plague virulence factor identified

Researchers at Duke University Medical Center have identified a previously unknown family of virulence factors that make the bacterium responsible for the plague especially efficient at killing its host. In the process, the team not only demonstrated that the use of the common roundworm is a valid model for studying the virulence of Yersinia pestis, the bacterium that causes plague. They a...

Doctors should stop prescribing antibiotics for the common cold, review advises

Antibiotics should not be prescribed to patients with the common cold because there is scant evidence they stop other infections, and the benefits do not outweigh the risks, according to a new systematic review of current evidence. "Antibiotics appear to have no benefit in the treatment of acute upper respiratory tract infections," conclude Dr. Bruce Arroll and Dr. Timothy Kenealy of the U...

Stanford doctors advance in bid to turn mice stem cells into blood vessels

Researchers at the Stanford University School of Medicine have taken a first step toward growing blood vessels from stem cells that could eventually be transplanted into living organisms. Starting with embryonic stem cells derived from mice, surgical resident Oscar Abilez, MD, and colleagues have successfully differentiated the stem cells into myocytes, one of the building blocks of blood...

Most important actors in the growth process of neurons identified

Defects in the growth process of our neurons often underlie brain or nerve diseases, such as Alzheimer's disease or multiple sclerosis. Scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the Katholieke Universiteit Leuven, led by Bassem Hassan, have achieved a major step in unraveling the growth process of axons, the offshoots of neurons. They have identif...

New Discovery May Help Doctors Treat Infertility

New research suggests that medications commonly referred to as fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta. The study showed that fertility drugs did not improve ovulation rates in mice that were genetically engineered to lack estrogen receptor beta. The estrogen receptor beta is one of two estrogen receptor proteins which mediate the effects of...

Microreactor efficiently regenerates cofactors for biocatalysis

One of the longstanding challenges in the synthesis of pharmaceuticals, cosmetics and food additives is the continuous regeneration of molecules called cofactors that permit the synthesis through inexpensive and environmentally friendly biocatalytic processes. Now, a team of researchers from the University of Illinois at Urbana-Champaign and the Universite Paul Sabatier in Toulouse, France...

Making plant cells work like miniature factories

Ames Laboratory researchers explore new frontier of metabolomics. Now, a group of researchers at the U.S. Department of Energy's Ames Laboratory at Iowa State University will use $1.02 million...

Lactose intolerance linked to ancestral environment

Got milk? Many people couldn't care less because they can't digest it. A new Cornell University study finds that it is primarily people whose ancestors came from places where dairy herds could be raised safely and economically, such as in Europe, who have developed the ability to digest milk. On the other hand, most adults whose ancestors lived in very hot or very cold climates that couldn...

Studies clarify risk factors for mother-to-child transmission of hepatitis C virus

Breastfeeding does not raise the risk of mother-to-child transmission of hepatitis C virus (HCV), according to two new studies published in the December 1 issue of The Journal of Infectious Diseases, now available online. One study found that infant girls are twice as likely to be infected as infant boys. Both studies provide new information with which to counsel pregnant women infected...

DNA size a crucial factor in genetic mutations, study finds

Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA. The findings, reported in the Oct. 25 online edition of the Proceedings of the National Academy of Sciences (PNAS), may reveal new insights into how genetic mutations-tiny mistakes that occur during DNA replication-arise. The discovery was made in the laboratory o...

New factor implicated in allergy and asthma attacks

For a person with allergies or asthma, breathing in pollen can be a very bad thing. Within minutes of inhalation by someone sensitive to their effects, these tiny particles can trigger severe inflammation of the respiratory passages, producing uncontrollable sneezing, coughing, or extreme shortness of breath -- symptoms agonizingly familiar to those who suffer from allergy and asthma attacks....

Gene controls whether fear is a factor

In the Nov. 18 issue of Cell, researchers report the discovery of a gene that controls the ability to react with appropriate fear to impending danger. As a result, mice lacking the gene stathmin become daredevils of a sort, the researchers report. The basic findings may have general implications for the study of anxiety disorders and potential anti-anxiety drugs, according to researchers....

Olfactory system detects pheromones that control reproduction

Howard Hughes Medical Institute researchers have discovered that pheromones essential for mating behavior in mice are recognized by the nose and not by the vomeronasal system, as researchers had long suspected.The new studies demonstrate that the main olfactory epithelium, which was presumed to be mostly involved with the sense of smell, plays a critical role in pheromone detection. Howar...

Should doctors tell patients about expensive, unfunded drugs?

It is unethical and paternalistic for doctors to withhold information from patients about new drugs that are not yet publicly funded, say researchers in this week's BMJ. This raises several ethical dilemmas for doctors. Is it reaso...

Largest study of human 'interactome' reveals a novel way

Discoveries made during the first large-scale analysis of interactions between proteins in our cells hold promise for identifying new genes involved in genetic diseases, according to researchers at Johns Hopkins and the Institute of Bioinformatics (IOB) in Bangalore. The findings, reported in the March issue of Nature Genetics, were made using a database of more than 25,000 protein-protein...

For one Stanford doctor, the beat goes on during open-heart surgery

In a Stanford Hospital surgery room on a recent afternoon, heart surgeon Kai Ihnken demonstrated how he repositions the beating heart while it's still inside the chest of a 78-year-old man undergoing triple bypass surgery. The surgeon reached into the chest, lifted the beating heart out, then craned his neck to the side, just so, searching for the right spot on the back of the heart to attach the...

UCI researchers discover key factor for survival of human embryonic stem cells

Human embryonic stem cells (hES) offer great hope for the treatment of some devastating diseases, but finding a way to keep enough of these cells usable and healthy for transplantation in patients has been an ongoing problem. Now scientists at UC Irvine have discovered a way to keep large quantities of these cells alive, a finding that could potentially lead to mass production of hES cells for th...

How the octopus forms an elbow

The octopus arm is extremely flexible. Thanks to this flexibility--the arm is said to possess a virtually infinite number of "degrees of freedom"--the octopus is able to generate a vast repertoire of movements that is unmatched by the human arm. Nonetheless, despite the huge evolutionary gap and morphological differences between the octopus and vertebrates, the octopus arm acts much like a three-...

Evolutionary shifts in olfactory sensitivities in fruit flies

How do an animal's senses change as it evolves to occupy a new ecological niche? By comparing the olfactory system of the fruit fly Drosophila melanogaster, which feeds from multiple fruit types, with that of its sibling species D. sechellia, a specialist particularly drawn to a single fruit type, researchers have demonstrated how evolution can act on several different levels of a sensory system...

UC Riverside psychologist explores human perception, finds 'wow factor'

Faces tell the stories in UC Riverside Professor Larry Rosenblum's ecological listening lab, as volunteer test subjects show that they can "read" unheard speech -- not just from lips, but from the simple movements of dots placed on lips, teeth and tongue. They can also recognize people's voices just from seeing their faces, and vice versa, and seem to be able to distinguish among a variety...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

Scientists have discovered that a stem cell factor overexpressed both in brain tumor cells and in neurons following brain injury promotes tumor survival by inducing angiogenesis. The research study, published in the April issue of Cancer Cell, examines the interaction between tumor cells and surrounding tissues and may have substantial significance for design of more effective therapeutics for on...

Efficiency, not more doctors, is the prescription for aging population

Recent news reports that threaten a shortage of doctors to treat the burgeoning elderly population are wrong, according to researchers at Dartmouth Medical School's Center for the Evaluative Clinical Sciences (CECS). In a study published in the March/April issue of Health Affairs, they argue that if employed efficiently, the current supply of physicians and medical students will be adequate thro...

With few factors, adult cells take on character of embryonic stem cells

With the introduction of just four factors, researchers have successfully induced differentiated cells taken from mouse embryos or adult mice to behave like embryonic stem cells. The researchers reported their findings in an immediate early publication of the journal Cell, published by Cell Press. The cells--which the researchers designate "induced pluripotent stem cells" (iPS)--exhibit t...

Nutrition a major factor in rise in twin pregnancies

The commonly held view that IVF is the only culprit in the steady increase in the numbers of twins born over the past thirty years was challenged by a scientist speaking at the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic, Wednesday 21 June 2006. Professor Robert Jansen, Medical Director of Sydney IVF, Sydney, Australia, said that...

Chromosomal abnormalities in sperm higher after vasectomy reversal

Men who have had a vasectomy reversed have a very much greater rate of chromosomal abnormalities in their sperm than do normal fertile men, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic on Wednesday 21 June 2006. Professor Nares Sukchareon, of the Department of Obstetrics and Gynaecology, Chulalongkorn Universi...

Patients and their doctors have different perceptions about HIV and its treatment

According to results of a nation-wide study published in the latest issue of SAGE Publications' Journal of the International Association of Physicians in AIDS Care (JIAPAC), HIV positive patients and their doctors have very different views about the disease and how it's treated. The study uncovered differences of opinion between patients and physicians about the initiation of treatment, th...

Impressive new Impact Factors for BioMed Central's open-access journals

Eleven journals published by BioMed Central, the open access publisher, received their first Impact Factor this month. With nine journals in the top 10 of their 2005 Journal Citation Report* category, and ten journals with a 2005 Impact Factor exceeding 3.00, open access journals are confirmed as publishing high-quality, highly cited research. Genome Biology, BioMed Central's flagship titl...

With few factors, adult cells take on character of embryonic stem cells

With the introduction of just four factors, researchers have successfully induced differentiated cells taken from mouse embryos or adult mice to behave like embryonic stem cells. The researchers reported their findings in an immediate early publication of the journal Cell. The cells--which the researchers designate "induced pluripotent stem cells" (iPS)--exhibit the physical, growth, and...

MatBase -- A new transcription factor knowledge base released by Genomatix

Genomatix Software GmbH, a pioneer and leader in the analysis of eukaryotic transcriptional regulation, releases MatBase, a knowledge base of transcription factors (TF). It contains genomic TF binding sites and protein binding domains, related literature, more than 27.000 known TF ?gene interactions, experimentally verified complexes with other TFs (promoter modules), and weight matrix de...