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Bipolar in Biological News

New light on bipolar treatment drugs

Lithium has been established for more than 50 years as one of the most effective treatments for bipolar mood disorder. However, scientists have never been entirely sure exactly how it operates in the human brain. Now, new research from Cardiff University scientists suggests a mechanism for h...

Largest study of its kind implicates gene abnormalities in bipolar disorder

The largest genetic analysis of its kind to date for bipolar disorder has implicated machinery involved in the balance of sodium and calcium in brain cells. Researchers supported in part by the National Institute of Mental Health, part of the National Institutes of Health, found an association bet...

Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms

Nematode worms treated with lithium show a 46 percent increase in lifespan, raising the tantalizing question of whether humans taking the mood affecting drug are also taking an anti-aging medication. Results of the Buck Institute study, led by faculty member Gordon J. Lithgow, PhD, are currently p...

Brain holds clues to bipolar disorder

Looking into the brain is yielding vital clues to understanding, diagnosing and treating bipolar disorder, according to findings being presented today at the Seventh International Conference on Bipolar Disorder. Two studies, featured in a press briefing held at 12:15 p.m., Thursday, June 7, have h...

Genetic roots of bipolar disorder revealed by first genome-wide study of illness

The likelihood of developing bipolar disorder depends in part on the combined, small effects of variations in many different genes in the brain, none of which is powerful enough to cause the disease by itself, a new study shows. However, targeting the enzyme produced by one of these genes could l...

Lithium builds gray matter in bipolar brains, UCLA study shows

Neuroscientists at UCLA have shown that lithium, long the standard treatment for bipolar disorder, increases the amount of gray matter in the brains of patients with the illness. The research is featured in the July issue of the journal Biological Psychiatry and is currently available online. ...

New gene linked to bipolar disorder

A new gene linked to both depression and bipolar disorder has been identified by UCL (University College London) and Danish researchers. The collaboration, led by Professor Hugh Gurling at UCL and Professor Ole Mors at the University of Aarhus, first looked at bipolar cases in families living i...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

Researchers at the University of Pennsylvania School of Medicine discovered that a key receptor protein is a critical component of the internal molecular clock in mammals. What's more, this molecule –called Rev-erb?is sensitive to lithium and may help shed light on circadian rhythm disorders, inclu...

Beyond lithium for bipolar disorder

While lithium treatment has proven to be a godsend for many of the two million Americans with bipolar disorder, it is not without its downside. People on the drug may develop hypothyroidism, tremors, cognitive impairment, and excessive thirst and urination and gain weight. However, better treatme...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

...l update sessions at the ECNP Congress will deal with the current knowledge on GABA and biomarkers in neuropsychopharmacology, treatment of insomnia, bipolar disorders and schizophrenia, as well as the new classification systems ICD-11 and DSM-V. Three poster sessions with in total more than 900 poster p...

22nd Congress of the European College of Neuropsychopharmacology

...ational update sessions at the congress will deal with the current knowledge on GABA and biomarkers in neuropsychopharmacology, treatment of insomnia, bipolar disorders and schizophrenia, and the new classification systems ICD-11 and DSM-V. ...

Lithium may help radiation target cancer, spare healthy tissue

... Vanderbilt-Ingram Cancer Center investigators have uncovered a mechanism that helps explain how lithium, a drug widely used to treat bipolar mood disorder, also protects the brain from damage that occurs during radiation treatments. In the May 1 issue of the Journal of Clinical Investig...

Research supports toxoplasmosis link to schizophrenia

...xoplasmosis parasite may trigger the development of schizophrenia and other bipolar disorders. The team from the University of Leeds' Faculty of Biological ... which focuses on mental health conditions and has a particular emphasis on bipolar illnesses. Dr McConkey says: "It's highly unlikely that we will find on...

Chantix side effects no worse with depression history

...ne serious psychiatric event involving suicidal thoughts and requiring hospitalization. It was in a person who had a previously undisclosed history of bipolar disorder. ...

Rethinking the genetic theory of inheritance

...ic twin, the different susceptibility of males (e.g. to autism) and females (e.g. to lupus), significant fluctuations in the course of a disease (e.g. bipolar disorder, inflammatory bowel disease, multiple sclerosis), among numerous others. "Traditionally, it has been assumed that only the DNA sequence c...

MU researcher identifies possible genetic causes of borderline personality disorder

... COLUMBIA, Mo. According to the National Institute of Mental Health, borderline personality disorder (BPD) is more common than schizophrenia or bipolar disorder and is estimated to affect 2 percent of the population. In a new study, a University of Missouri researcher and Dutch team of research collab...

USC researchers head global effort to study genetic risks that contribute to psychiatric diseases

...r to study the genetic risks for schizophrenia and bipolar disorder. The USC Center for Genomic Psychiatr... the disorder. They will study 5,000 patients with bipolar disorder as part of a coordinated effort led by MG....D., to collect an additional 19,000 patients with bipolar disorder. The cohort will be the largest coord...

Bipolar disorder genes, pathways identified by Indiana University neuroscientists

...omprehensive map of genes likely to be involved in bipolar disorder, according to research published online N...large-scale international gene hunting studies for bipolar disorder with information from their own studies a...er and created a comprehensive biological model of bipolar disorder. "Based on our work, we now project t...

Ultrasound shown to exert remote control of brain circuits

...ain Stimulation (DBS) and Vagal Nerve Stimulation (VNS) have been shown to be effective in the management of psychiatric disorders such as depression, bipolar disorders, post-traumatic stress disorder, and drug addition, as well as for therapies of neurological diseases such as Parkinson's disease, Alzheimer...

NARSAD announces 2008 Prizes for Outstanding Achievement in Research on Mental Health Disorders

...sts whose research in the areas of schizophrenia, bipolar disorder and depression, childhood disorders and c...the symptomatic and biological characterization of bipolar disorder, as well as the effectiveness of mood-sta...ession, anxiety disorders, including PTSD and OCD, bipolar disorder, schizophrenia, childhood mental disorder...

Brain-nourishing molecule may predict schizophrenia relapse

...e drug is becoming less effective and a relapse is imminent, the researchers say. Decreased BDNF levels already have been associated with relapsing bipolar disease and depression, Dr. Buckley says. Dr. Pillai and others have shown that the BDNF levels in patients with schizophrenia are generally lower tha...

Study provides insight on a common heart rhythm disorder

...ls with electrical activity," he added. "In addition to heart disease, ankyrins could be involved in other 'excitable' cell diseases such as epilepsy, bipolar disease and diabetes." ...

Eli and Edythe L. Broad make unprecedented gift to endow Broad Institute of Harvard & MIT

...ion to common human diseases; Identifying scores of new genetic risk factors for diseases such as type 2 diabetes, Crohn's disease, schizophrenia, bipolar disorder, autism, cardiovascular disease, and a variety of cancers; Classifying human cancers by their genomic alterations, rather than by their l...

Healthy Minds Across America features 48 public forums on mental health research, Sept. 14

...s and progression of such illnesses as depression, bipolar disorder, anxiety, schizophrenia and autism, and l...lness: The role genes play in risk for depression, bipolar disorder and schizophrenia, and what we're learnin...ntial treatments for schizophrenia, depression and bipolar disorder; Improving pharmaceutical treatments: D...

Risks and benefits of antipsychotics in children and adolescents

...reatment of conditions such as severe conduct disorders, Tourette syndrome, bipolar disorder and schizophrenia in children and adolescents. Treatment advances,...reatment of psychotic disorders in children and adolescents (schizophrenia, bipolar disorders), as well as conduct disorders, Tourette syndrome, and tics (Jens...

Study finds connections between genetics, brain activity and preference

...EB1 that has been implicated in animal studies of the brain's reward/aversion function. Study lead author Roy Perlis, MD, medical director of the MGH bipolar Program, and colleagues previously found that depressed men with a particular variation near the gene coding for CREB report greater difficulty suppre...

Scientists learn how food affects the brain

...s in humans has been associated with increased risk of several mental disorders, including attention-deficit disorder, dyslexia, dementia, depression, bipolar disorder and schizophrenia," he said. "A deficiency of omega-3 fatty acids in rodents results in impaired learning and memory." Children who had...

At Boston symposium, NARSAD researchers report on genes and family traits

...many psychiatric illnesses, such as schizophrenia, bipolar disorder and depression. Presented at NARSAD's ... susceptibility to and pathology of schizophrenia, bipolar disorder and depression, some of the most severe, ...y Traits Provide Clues to Genes for Schizophrenia, bipolar Disorder It is also important to identify the ...

Epigenetic changes discovered in major psychosis

...ientists have discovered epigenetic changes (i.e. chemical changes to a gene that do not alter the DNA sequence) in individuals with schizophrenia and bipolar disorder. This is the first epigenome-wide investigation in psychiatric research, and this groundbreaking data may be a significant step on the journe...

Advertisers, neuroscientists trace source of emotions in brain

...ads, they found the fMRI data and response converged on two of three measures pleasure-displeasure and excitement-calm. Under the AdSAM system, these bipolar dimensions as well as a third, dominance-submissiveness form the foundation for more specific emotions. Where the researchers compared the AdSAM ...

New studies on schizophrenia, depression, trauma and autism highlight annual meeting

...an impact on areas of the brain that contribute to bipolar disorder or schizophrenia in youth, according to n... found size difference in the brains of youth with bipolar disorder and schizophrenia, which could help ident...terns and Regular Routines May Improve Outcomes in bipolar Disorder...

Duke scientists map imprinted genes in human genome

...chromosome 8, where none had been found before. One of them, KCNK9, is mostly active in the brain, is known to cause cancer, and may also be linked to bipolar disorder and epilepsy. The second, DLGAP2, is a possible bladder cancer tumor suppressor gene. Hartemink says experiments to confirm that all 156...

Team of scientists develops non-invasive method to track nerve-cell development in live human brain

...e brain, which can be a sign of cancer. In other patients, it could show us how neurogenesis is related to the course of diseases such as depression, bipolar disorder, Alzheimers, Parkinsons, MS, and post-traumatic stress disorder. In 2006, Dr. Enikolopov demonstrated that the antidepressant fluoxetine (...

NARSAD presents 2007 prizes for outstanding achievement in neuroscience and psychiatric research

...eptional contributions to the understanding and treatment of schizophrenia, bipolar disorder, depression, autism, obsessive compulsive disorder (OCD), Tourette...iology and prediction of pharmacological treatment response in unipolar and bipolar affective disorders using brain imaging with PET. She then utilized this i...

Mental disorders are disorders of the brain

...onths, such as depression, specific phobias, somatoform disorders, alcohol- and drug dependence, social phobia, generalized anxiety disorder (GAD), bipolar disorder, psychotic disorders, obsessive compulsive disorder (OCD) or eating disorders. The estimated total number of affected is 82,7 million in an...

20th ECNP Congress 2007, Oct. 13-17, Vienna, Austria

... In addition, cutting edge research findings in the fields of Depression, bipolar Affective Disorders, Schizophrenia, Anxiety Disorders, Obsessive Compulsive...ducational track the Report of the ECNP Consensus Meeting 2007 on the topic bipolar depression. With annual consensus meetings on specific topics ECNP aims to ...

A unique arrangement for egg cell division

...nds up with the correct number of chromosomes is a bipolar spindle consisting of protein filaments, called mi... the microtubules originate. They predetermine the bipolar structure of the spindle that is essential to extr... understand how mammalian oocytes could assemble a bipolar spindle without such centrosomes. Tracking spindl...

Gene malfunctions cause schizophrenia, depression symptoms in mice

...1), which had been found in one family to be associated with schizophrenia, bipolar disorder, and major depression. The researchers' theory was that diffe...ngs lend further credence to the growing recognition that schizophrenia and bipolar disorder share, at least in part, common genetic etiologies and thus underl...

Brain networks strengthened by closing ion channels

...aging, and for cognitive changes in schizophrenia, bipolar disorder, or attention deficit hyperactivity disor...y disrupted in disorders such as schizophrenia and bipolar disorder. The current study found that brain ...ore severe mental illnesses like schizophrenia and bipolar disorder, which can involve mutations of a molecul...

Studies look at how genes affect antipsychotic drug response

...o treat mental illnesses such as schizophrenia and bipolar disorder. Jeffrey Bishop, assistant professor ...in in children ages 8-18 who suffer from pediatric bipolar disorder. An increase in prolactin (a pituitary ho...aid. Risperidone is widely prescribed to treat bipolar disorder in children, accounting for half of all a...
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