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Plant protein 'doorkeepers' block invading microbes, study finds

A group of plant proteins that "shut the door" on bacteria that would otherwise infect the plant's leaves has been identified for the first time by a team of researchers in Denmark, at the University of California, Davis, and at UC Berkeley. Findings from the study, which will appear June 29 in...

Plant protein 'doorkeepers' block invading microbes, study finds

A group of plant proteins that "shut the door" on bacteria that would otherwise infect the plant's leaves has been identified for the first time by a team of researchers in Denmark, at the University of California, Davis, and at UC Berkeley. Findings from the study, which will appear June 29 in...

Salt block unexpectedly stretches in Sandia experiments

To stretch a supply of salt generally means using it sparingly. But researchers from Sandia National Laboratories and the University of Pittsburgh were startled when they found they had made the solid actually physically stretch. "It's not supposed to do that," said Sandia principal investig...

Small molecules might block mutant protein production in Huntington's disease

DALLAS May 3, 2009 Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease, researchers at UT Southwestern Medical Center have found. These man-made molecules also were effective against the abnormal ...

TGen researchers discover possible way to block the spread of deadly brain tumors

PHOENIX, Ariz. April 17, 2009 Researchers at the Translational Genomics Research Institute (TGen) may have found a way to stop the often-rapid spread of deadly brain tumors. A gene with the playful-sounding name NHERF-1 may be a serious target for drugs that could prevent malignant tumors fro...

Long-lasting nerve block could change pain management

Researchers at Children's Hospital Boston have developed a slow-release anesthetic drug-delivery system that could potentially revolutionize treatment of pain during and after surgery, and may also have a large impact on chronic pain management. In NIH-funded work, they used specially designed fat...

Small molecules block cancer gene

HOUSTON (March 10, 2009) Finding molecules that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, ...

Researchers block damage to fetal brain following maternal alcohol consumption

BETHESDA, Md. (August 11, 2008) − In a study on fetal alcohol syndrome, researchers were able to prevent the damage that alcohol causes to cells in a key area of the fetal brain by blocking acid sensitive potassium channels and preventing the acidic environment that alcohol produces. The cer...

Pregnant mice block out unwelcome admirers to protect their pups

Mouse mothers-to-be have a remarkable way to protect their unborn pups. Because the smell of a strange male's urine can cause miscarriage and reactivate the ovulatory cycle, pregnant mice prevent the action of such olfactory stimuli by blocking their smell. Researchers from the European Molecular ...

'Knocking out' cell receptor may help block fat deposits in tissues, prevent weight gain

CINCINNATIUniversity of Cincinnati (UC) pathologists have identified a new molecular target that one day may help scientists develop drugs to reduce fat transport to adipocytes (fat cells) in the body and prevent obesity and related disorders, like diabetes. Detailed in the Oct. 18 online edit...

New molecules discovered that block cancer cells from modifying cell DNA

Lake Tahoe, CA, October 11, 2007 Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in t...

Scientists make chemical cousin of DNA for use as new nanotechnology building block

In the rapid and fast-growing world of nanotechnology, researchers are continually on the lookout for new building blocks to push innovation and discovery to scales much smaller than the tiniest speck of dust. In the Biodesign Institute at Arizona State University, researchers are using DNA to...

First-degree fetal heart block may be reversible

There is an increased risk of fetal heart problems when mothers carry particular antibodies associated with rheumatic diseases, according to an abstract presented by Yale School of Medicine researchers at the Society for Maternal-Fetal Medicine Conference February 9 in San Francisco. Congenital ...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

Despite the fact that they both infect the liver, the hepatitis A and hepatitis C viruses actually have very little in common. The two are far apart genetically, are transmitted differently, and produce very different diseases. Hepatitis A spreads through the consumption of fecal particles from an ...

Scientists discover way to block growth of prostate cancer cells

Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer. They found that a drug that blo...

Defense peptide found in primates may block some human HIV transmissions

As primates evolved 7 million years ago, the more advanced species stopped making a protein that University of Central Florida researchers believe can effectively block the HIV-1 virus from entering and infecting blood cells. HIV-1 often mutates quickly to overcome antiviral compounds designed t...

Study details hepatitis C ability to block immune system response

The study was published in an advance online edition of the Proceedings of the National Academy of Sciences on May 17. Hepatitis C virus (HCV) is a worldwide public health problem. The World Health Organization estimates that 170 million people worldwide are chronically infected and that between...

Enzyme inhibitors block replication of SARS virus

The study was conducted by researchers from Scripps Research; the Genomics Research Center, Academia Sinica, Taiwan; and the National Taiwan University. It is being published today in the journal Chemistry and Biology (Vol. 13, No. 3). Chi-Huey Wong is currently the Ernest W. Hahn Chair in Chemis...

Polymer gel can block toxic leakage problem in gene therapy

Duke University biomedical engineers have devised a potentially patentable method to arrest toxic leakages of genetically engineered viruses that have plagued attempts to use gene therapy against cancerous tumors. The problem has been that viruses carrying anti-tumor genes have tended to leak from ...

'Nanospheres' that block pain of sensitive teeth

Nanospheres could help dentists fill the tiny holes in our teeth that make them incredibly sensitive, and that cause severe pain for millions of adults and children worldwide. Preliminary research presented today at the Institute of Physics conference EMAG-NANO 2005 shows that creating tiny sphe...

Scientists use gene transfer technology and common virus to block neuropathic pain

Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it. It's called neuropathic pain, and it's a common complication of many diseases and m...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

Remember how it felt the last time you burned your finger on a hot stove? Imagine what it's like to have that burning pain in your hands or feet all the time and know there's virtually nothing you can do about it. David Fink, M.D.It's called neuropathic pain, and it's a common complication of ma...

Frog peptides block HIV in lab study

In the human brain, cells talk to one another through the routine exchange of electrical signals. But when people fall into a deep sleep, the higher regions of the brain - regions that during waking hours are a bustling grid of neural dialogue - apparently lose their ability to communicate effectiv...

Tamoxifen-like drug suggests new ways to selectively block estrogen

The ability of an experimental drug known as GW5638 to change the shape of the estrogen receptor is helping researchers understand why drugs like tamoxifen and raloxifene behave the way they do, simulating the effects of estrogen in some tissues and blocking it in others. The finding indicates that...

NIH stimulus funding supports Emory biomedical scientists

...ing the growth of a tumor. This project examines Syk, a molecule that appears to push blood vessels to grow in response to low oxygen. Finding ways to block such growth signals could generate new tools to fight cancer. New treatments for epilepsy: Some epilepsy patients cannot control their seizures wit...

La Jolla Institute discovers novel tumor suppressor

...eta 3 gene eventually developed severe myeloproliferative disease. The team determined that tumor production hinged on the PLC-beta 3's ability to block the action of STAT5, a transcription factor protein than can switch on many genes known to control cell proliferation, survival and, in the case of b...

Nottinghamshire Police First Law Enforcement Agency to Deploy ForensicSoft in United Kingdom

... digital forensic investigations. Employing ForensicSoft's proprietary SAFE block technology to block all disks at the physical level, SAFE is the only Windows-based boot enviro...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...em, Medical College of Georgia scientists say. Researchers are comparing chemical alterations, called DNA methylation, in the body's basic building block in healthy colon, breast, brain and lymphatic cells and their cancerous counterpart to find telltale patterns that could one day be detected in the bl...

Scientists link immune system's natural killer cells to infant liver disease

...oon after birth, and they have implications for developing new therapies to block the disease by targeting certain cells or pro-inflammatory circuits," said ...side the bile ducts are damaged, which in turn allows inflammatory cells to block the duct and the ongoing accumulation of fibrotic tissue. Biliary atresia a...

Flexible neck in cell-receptor DC-SIGN targets more pathogens

...hemistry at the U. of I. "Once we begin to understand the molecular design rules that lead to this tight binding, we can begin to design inhibitors to block this interaction." To study the binding behavior of DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin), also ...

Munich researchers discover new target for tailored antibiotics

...ss, and the helpers involved in the IspH reaction have been identified," explains Groll, "we have a new angle of attack for developing substances that block the terminal step in the bacterial synthesis of isoprene building blocks, thereby killing pathogens in a very targeted way. Since the enzyme and the a...

GUMC discovery highlights new direction for drug discovery

... Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare ...use the notion long accepted among scientists is that it is not possible to block protein-protein interactions given that the surface of many of these protei...

Discovery may provide new treatments for alcohol dependence

... able to produce its addictive effects, that include reward searching behaviour (akin to craving in alcoholic patients). "If we can develop drugs that block the receptors for ghrelin, we could have a new effective treatment for alcohol dependence. It may however take several years until such a pharmacologi...

New MRI technique could mean fewer breast biopsies in high-risk women

...undaries of a lesion often stand out very clearly when embedded in fat." block and his colleagues currently are gathering data on the efficacy of the tech..., a UW-Madison assistant professor of biomedical engineering and radiology, block and colleagues also are refining ways to image both breasts simultaneously ...

New trigger for chronic inflammation in rheumatoid arthritis discovered

..., according to new research published today in Nature Medicine . The authors of the study, from Imperial College London, say that if scientists could block this signal, it may be possible to develop more effective arthritis treatments. Rheumatoid arthritis is the most common autoimmune disease, affecti...

Tryptophan deficiency may underlie quinine side effects

... Researchers have found that the anti-malarial drug quinine can block a cell's ability to take up the essential amino acid tryptophan, a discovery that may explain many of the adverse side-effects associated with quinine...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

...p90. Experience with Hsp90 inhibitors already under study for cancer shows they tend to migrate to the highly active Hsp90 in tumors. He wants to block Hsp90 in cancer cells by learning more about how it works in normal and cancer cells. A recent grant from the American Heart Association will enable h...

Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues

...oncentrations. In vivo studies using VCaP cell xenografts showed reduced tumour growth in response to disulfiram exposure; disulfiram was not able to block tumour growth indicating the need for combined approaches. Disulfiram induced metallothionein expression, knockdown of MTI increased efficiency by f...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

...cts the predoctoral research training program of the UC Davis Clinical and Translational Science Center (CTSC). "Presently, we have medications that block related pathways in asthma, but what we will look at is very new. We are excited to see if soluble epoxide hydrolase inhibitors, with or without th...

Research uncovers clues to virus-cancer link

...iruses take over cellular systems, resulting in cancer, is a promising strategy for cancer prevention and treatment, since it is much more feasible to block viral infection or develop specific inhibitors of the viral genes than try to inhibit all of the genetic changes within a cancer. ...
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