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Antiviral in Biological News

Avian flu becoming more resistant to antiviral drugs, says University of Colorado study

A new University of Colorado at Boulder study shows the resistance of the avian flu virus to a major class of antiviral drugs is increasing through positive evolutionary selection, with researchers documenting the trend in more than 30 percent of the samples tested. The avian flu, an Influenza ...

Study: Excessive use of antiviral drugs could aid deadly flu

COLUMBUS, Ohio Influenza's ability to resist the effects of cheap and popular antiviral agents in Asia and Russia should serve as a cautionary tale about U.S. plans to use the antiviral Tamiflu in the event of widespread avian flu infection in humans, scientists say. Researchers analyzed almos...

NIAID funds studies of how SARS and bird flu evade antiviral responses

The National Institute of Allergy and Infectious Diseases (NAID), one of the National Institutes of Health, has awarded a contract to the University of Washington (UW) to use systems biology approaches to comprehensively analyze and model the virus-host interactions and cellular response networks ...

Feline virus, antiviral drug studied to understand drug resistance

COLUMBUS , Ohio Researchers at Ohio State will spend the next two years testing their theories about just how an AIDS-like virus in cats is able to resist the powerful medicines that are thrown against it. It's one of the latest efforts at understanding one of the leading problem areas in medi...

Bird flu -- Call for antiviral drugs to be shared

New predictions about bird flu, involving the use of a mathematical model, suggest that international cooperation to share antiviral drugs might be the best way to deal with an emerging pandemic. 'Bird flu'(avian H5N1 influenza) has not triggered a worldwide human epidemic yet because it rarely p...

The reason why antiviral therapy can't annihilate HIV infection, and what to do about it

Antiviral therapy has been used to suppress HIV replication and has dramatically improved the clinical course of disease in affected patients. But the existence of viral reservoirs precludes the complete elimination of HIV from treated patients. In a new study appearing on November 1 in The Journa...

New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus

Findings reported in Science help explain why Spanish flu was so lethal. The 1918 Spanish flu was a global disaster, killing an estimated 20 to 50 million people, many of them otherwise healthy adults. By partially reconstructing the Spanish flu virus, researchers have now discovered at least part ...

Biota makes major antiviral discovery

Biota Holdings Limited announced today that it has discovered a new class of orally-effective, potent antivirals against RSV (respiratory syncytial virus) infection. Biota has filed worldwide patents and selected a lead candidate with a series of backups for further preclinical development prior to...

Novel antiviral technology inhibits RSV infection in mice

A novel antiviral treatment combining nanoparticle and gene silencing technologies thwarts attacks of respiratory syncytial virus (RSV) -- a virus associated with severe bronchitis and asthma, an animal study by University of South Florida researchers found. The study was reported in the January 20...

First human gets new antibody aimed at hepatitis C virus

...e most serious cases of HCV that do not respond to antiviral drugs, liver transplantation is the only option. ...patient's bloodstream during surgery. The powerful antiviral drugs now used to attack HCV prior to end-stage li...the antibody could be used in combination with new antiviral drugs for treatment in patients with newly diagnos...

Scientists decoding genomic sequences of H1N1 using isolates from outbreak in Argentina

...n as soon as possible," said Dr. Lipkin. "While there is no evidence so far to indicate the emergence of resistance to the oseltamivir vaccine, the antiviral drug that blocks the influenza virus from spreading between cells in the body, we are cautious about the findings until we have more sequences," said ...

K-State researcher, collaborators study virulence of pandemic H1N1 virus

... different clinical outcomes," he said. Establishing animal models for pandemic H1N1 is important, Richt said, because physicians have two types of antiviral medications to treat influenza. One type, called adamantine-like drugs, targets the M2 protein; the other type includes drugs like Tamiflu that target...

UCSF researchers identify new drug target for Kaposi's sarcoma

...vance Online Publication section of the " Nature Chemical Biology " web site and can be found at www.nature.com/nchembio/index.html . Most current antiviral drugs target the active sites of viral proteins, where enzymes and receptors work in a lock-and-key approach to either activate or deactivate that par...

MicroRNAs help control HIV life cycle

...ng the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs. The research was published today in the journal Molecular Cell . Tariq Rana, Ph.D., director of the Program for RNA Biology at Burnham, and...

Targeting children effective use of limited supplies of flu vaccine and could help control flu spread

...res to control the spread of the disease. These measures include the use of antiviral treatment, social distancing (for example, closing schools and stopping pub...s, such steps may support other control measures such as social distancing, antiviral drugs or quarantine." The current study focuses on household transmissi...

Government of Canada announces funding for research on the H1N1 flu virus

...Guy Boivin at Universit Laval and his team will work with a national team to track the evolution of the H1N1 flu virus, evaluate its susceptibility to antiviral drugs, and identify new potential therapeutic compounds to combat viral resistance. Dr. Babak Pourbohloul at the University of British Columbia an...

SRI International to screen drugs that fight 2009 H1N1 influenza A

...the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. There is currently only one class of antiviral drugs, the neuraminidase inhibitors, available to treat this H1N1 infection. Identifying drugs from other chemical and mechanistic classes could provi...

Visualizing virus replication in three dimensions

...s C virus. In addition, it offers new approaches for developing measures to prevent or treat dengue fever. Up to now, neither a vaccine nor a specific antiviral therapy exists. Professor Dr. Ralf Bartenschlager, director of the Department of Molecular Virology at the Heidelberg Hygiene Institute and his t...

Novel antibody prevents infection by hepatitis C virus

...e most serious cases of HCV that do not respond to antiviral drugs, liver transplantation is the only option. ...patient's bloodstream during surgery. The powerful antiviral drugs now used to attack HCV prior to end-stage li...the antibody could be used in combination with new antiviral drugs for treatment in patients with newly diagnos...

Nanotechnology holds promise for STD drug delivery

... New Haven, Conn. Yale researchers describe a breakthrough in safe and effective administration of potential antiviral drugs small interfering RNA (siRNA) molecules that silence genes the first step in development of a new kind of treatment for sexually transmitted d...

West Nile virus studies show how star-shaped brain cells cope with infection

...s to cause life-threatening inflammation. "Studies such as this take us one step closer to understanding both the risk and benefit associated with antiviral immune response and may lead to new treatment strategies," said W. Ian Lipkin, the senior researcher involved in the study, who also is the director o...

New edition available for essential virology reference

...ogic patterns, new syndromes, unmet vaccine needs, antiviral drug resistance, and threats of bioterrorism are b...immunization strategies, and an expanding array of antiviral agents. The demands on clinicians, public health ...tions. In addition, the rapidly expanding field of antiviral drugs demanded dividing the subject into two chapt...

Evolutionary biologist will study HIV with grant from AIDS research foundation

...ant professor of molecular genetics and microbiology at The University of Texas at Austin. "Those will be good targets for blocking the virus with new antiviral drugs." Viruses and their hosts are constantly evolving to thwart each other in an arms race that occurs over many generations and results in evolu...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

...n the event of a pandemic, the antibodies could be used in combination with antiviral therapies to contain the outbreak until a vaccine became available. The pro...e in humans that would cover a broad range of different H5N1 virus strains. antiviral medications, including the neuraminidase inhibitor oseltamivir (Tamiflu ), ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

...n the event of a pandemic, the antibodies could be used in combination with antiviral therapies to contain the outbreak until a vaccine became available. The pro...e in humans that would cover a broad range of different H5N1 virus strains. antiviral medications, including the neuraminidase inhibitor oseltamivir (Tamiflu), i...

Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs

...cal University of South Carolina and North Carolina State University has found several compounds which exhibit very strong antibiotic, antifungal, and antiviral potential as well as some anti-cancer and angiogenesis activities. The research into coral disease has resulted in thousands of new bacterial isolates...

Study: Fluid buildup in lungs is part of the damage done by the flu

... infected lungs. In the event of a flu pandemic, such a drug, which scientists hope could be inhaled by mouth, might be an important supplement to antiviral medications and ventilators, Davis said. The research is published in a recent issue of the American Journal of Respiratory and Critical Care Medi...

Scripps scientists create first crystal structure of an intermediate particle in virus assembly

...lities in the first stage of that assembly. "We believe that without its final shell to protect it, an immature virus will be much more defenseless to antiviral agents," he says. Knowing how viruses build these vessels to protect the naked viral DNA inside is also useful in the field of medical nanotechnolo...

Potential new herpes therapy studied

...s also been tested in mouse tissue and in rabbits. "They have found a very good experimental system in which they can convincingly show significant antiviral activity," Burke said. But the researchers still need to do more checks to see whether it is safe to move to human testing. Also, they want to deve...

American Association for the Advancement of Science honors four Iowa Staters

...raus' research program includes developing biobased products using catalysts. He's also working to synthesize biologically active molecules, including antiviral agents and plant-based drugs for treatment of type 2 diabetes. Surya Mallapragada, professor of chemical and biological engineering and field work ...

UQ research targets West Nile virus and dengue fever

...he virus genome. "To develop new and effective antiviral strategies, we have to know as much as possible ab...laviviruses we tested so far, targeting it with an antiviral therapy may be effective for the whole range of fl...ccine candidates as they are expected to elicit an antiviral immune response similar to the normal virus infect...

Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

..., and local killing of infected cells versus secretion of long-range active antiviral proteins. "This amount of control over T cells' response is remarkable....y says. "That suggests it may be possible to not only dramatically enhance antiviral or antitumor T cell responses, but also to fine tune which response you wan...

Researchers use chemical from medicinal plants to fight HIV

...s in the dish-and found that the treated CD8 cells inhibited production of HIV by the CD4 cells. "The ability to enhance telomerase activity and antiviral functions of CD8 T-lymphocytes suggests that this strategy could be useful in treating HIV disease, as well as immunodeficiency and increased suscepti...

Protein 'tubules' free avian flu virus from immune recognition

...in called H5N1 forms tiny tubules in which it "hides" the pieces of double-stranded RNA formed during viral infection, which otherwise would prompt an antiviral immune response from infected cells, said Baylor College of Medicine researchers in an online report in the journal Nature . Two domains or portio...

First comprehensive genomic study of common cold reveals new treatment targets

...o been classified; among them are genes which make antiviral compounds thought to help thwart infections. "T...d treatment: one that maintains the body's natural antiviral response while normalizing the inflammatory response." Of the many antiviral compounds made by the epithelial cells, one, calle...

European researchers harness unique properties of boron to develop new drugs and diagnostics

...e obvious during the workshop that there is now sufficient knowledge and enough compounds to support a broad program of screening in the quest for new antiviral and anticancer drugs containing essential boron components," said Lesnikowski. There was also scope for improving the application of BNCT to cancer, b...

Scripps research team sheds light on immune system suppression

...ally the same regardless of infection type. One key component of the innate immune system is interferon, which plays a range of roles including direct antiviral effects, activating innate natural killer cells and adaptive T lymphocytes, which destroy a wide range of infectious invaders. To better understan...

Sensitive nanowire disease detectors made by Yale scientists

...nic POC diagnostic devices available for disease detection. "Instruments this sensitive could also play a role in detection of residual disease after antiviral treatments or chemotherapy," said Fahmy. "They will help with one of the greatest challenges we face in treatment of disease knowing if we got rid of...

Why some primates, but not humans, can live with immunodeficiency viruses and not progress to AIDS

... generation of a less vigorous immune response to SIV may represent an effective evolutionary response to a virus that is so resistant to clearance by antiviral immune responses. The authors suggest new treatment strategies that would steer the immune system away from over-activation, thereby protecting ag...

Herpes drug inhibits HIV in patients infected with both viruses

... in French . Researchers at the U.S. National Institutes of Health (NIH), McGill University and other institutions have discovered how a simple antiviral drug developed decades ago suppresses HIV in patients who are also infected with herpes. Their study was published in the Sept. 11 issue of the journa...
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