Antibody in Biological News

First human gets new antibody aimed at hepatitis C virus

Boston, Mass. Building upon a series of successful preclinical studies, researchers at MassBiologics of the University of Massachusetts Medical School (UMMS) today announced the beginning of a Phase 1 clinical trial, testing the safety and activity of a human monoclonal antibody they developed ...

In vitro antibody production enables HIV infection detection in window period -- key to safer blood

This release is available in Chinese . Researchers in Israel and Kenya have shown that the contribution of variable degrees of immune suppression, either due to existing chronic infections such as parasitemi...

NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA

Hamburg, Germany and Copenhagen, Denmark, May 12th, 2009 / b3c newswire / – Richter-Helm BioLogics GmbH & Co. KG announces today a technological breakthrough in the field of purification of antibody fragments from an E. coli expression system. Richter-Helm BioLogics has finalized ...

Novel antibody prevents infection by hepatitis C virus

Boston, Mass. Taking aim at a leading cause of liver failure in the United States, a team of scientists at the Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

WHITEHOUSE STATION N.J., PRINCETON, N.J. and JAMAICA PLAIN, Mass., April 21, 2009 Merck & Co., Inc., (through an affiliate), Medarex, Inc. (NASDAQ: MEDX) and Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) today announced that they have signed an...

UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology

Bioinformatics researchers at the University of California, San Diego and Genentech have developed a new, quicker way to sequence monoclonal antibodies a process that is many times faster than the sequencing technology typically used by academic and industry researchers today. The breakthroug...

ETH Zurich researchers develop antibody test

ETH Zurich professor Peter Seeberger has been working on a sugar-based malaria vaccine for years. The new test takes him one important step closer to his goal. The malaria pathogen plasmodium falciparum carries poisonous sugar molecules called GPIs for short on its surface that are able to be in...

Bright lights: Mystery of glowing antibody solved by Scripps research scientists

Now, a group of Scripps Research scientists have shown that EP2-19G2, one of a panel of fluorescent monoclonal antibodies that were first reported in 2000, produces its distinctive bright blue glow through a rare and highly complex recombination of electrical charge. This charge recombination i...

Yale chemist receives NIH Young Investigator Award for antibody targeting

New Haven, Conn. David Spiegel , assistant professor of organic chemistry at Yale, has received a $1.5 million National Institutes of Health (NIH) Directors New Innovator Award that will support his work designing a rational approach for using antibodies to target a wide variety of cells and d...

Reversing cognitive deficits: Injectable antibody may attack source of problem

ST. LOUIS -- A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimers disease, Saint Louis University researchers have found. The protein -- part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amylo...

Newly discovered antibody may be body's natural defense against Alzheimer's

In an important advance in the battle against Alzheimer's disease, physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have identified naturally occurring antibodies in human blood that may help to defend against this form of dementia as well as other neurodegenerati...

Monoclonal antibody reduces exacerbations in asthmatics

Patients with symptomatic moderate asthma who were treated with anti-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced significantly fewer disease exacerbations than individuals taking a placebo. This research appears in the first issue for October 2006 of the Ame...

Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection

Effector T cells (Teff cells) are involved in activating and directing other immune cells, while regulatory T cells (Tregs) act to curb the over-aggressive responses of the T cell population. Researchers continue to work on devising ways to mobilize anti-tumor Teff cells in order to better shape ...

New antibody shows promise as cure for anthrax

A new anthrax antibody engineered by scientists at The University of Texas at Austin protects and defends against inhalation anthrax without the use of antibiotics and other more expensive antibodies. The high-affinity antibody, an anthrax antitoxin, successfully eliminated both anthrax bacteria ...

New cancer drug delivery system is effective and reversible

...cancer cells, with limited success. A common approach involves attaching an antibody to the liposome membrane. Ideally the antibody will bind to a cancer cell receptor so that it can deliver the liposome an...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...enter have successfully tested a small, engineered antibody they say shuts down growth of human glioblastoma t...nal Oncogene, the researchers demonstrate how this antibody latches onto a receptor that studs the outside of ...rives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in those canc...

Penn-Wistar team gains insight into HIV vaccine failure

...chers. These individuals were found to have high blood Ad5 neutralizing antibody (nAb) titers, the main immune gatekeeper in most vaccine strategies. Antibo...n activation or expansion of CD4 T-cells in either the high- or the low-Ad5 antibody groups. "It doesn't appear that vaccination increases the pool of poten...

Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax

...d Journal of Medicine of the results of two pivotal animal efficacy studies, which showed the life-saving potential of the Company's human monoclonal antibody drug raxibacumab (ABthrax), as well as the results of human safety studies, which supported the use of raxibacumab in the event of life-threatening in...

LSUHSC's Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia

...ned with a potent protein antigen called Kex1, these antibodies can regulate direct killing of the fungus and confer immunity. "Understanding these antibody responses will improve vaccine strategies for this human infection," notes Dr. Jay Kolls, who is also the principal investigator on the grant. ...

Virus-resistant grapevines

...of the plant. Using simple routine processes, the researchers introduce the antibody gene into the bacteria, which then act as a transport vehicle and carry it ... their modified versions are up to 100 percent resistant to the virus. "The antibody is produced very effectively inside the plants," says Schillberg. "The next...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

...sive breast cancers. HER2 was chosen for the development of an entirely novel cancer therapy, culminating in the production of an anti-HER2 monoclonal antibody that since 1998 has been used successfully to treat patients with metastatic breast cancer. This was the first targeted therapeutic agent developed o...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

...re more subgroups than originally thought. They included children with rheumatoid factor (RF) positive JIA, meaning their blood tested positive for an antibody commonly seen in adults with rheumatoid arthritis (RA). Surprisingly, the scientists found patterns of gene expression that indicated at least three s...

Another JDRF partner moves research forward with collaboration agreement for diabetes treatment

...Massachusetts, which has joined with GlaxoSmithKline to develop an anti-CD3 antibody to preserve beta cell function in newly diagnosed patients; Maryland-based MacroGenics, which is developing a similar antibody with Lilly; and Canada's Transition Therapeutics, which has signed a commer...

Tracking down the causes of multiple sclerosis

... there most be some kind of interaction between the T and B cells, that the resulting army of B cells triggers the full-blown form disease through its antibody attacks. More aggressive than others Even if B cells play a far more significant role than was previously believed, the fact remains that T ce...

InVitria Sponsors ESACT 2009 in Dublin, Ireland

...InVitria recently introduced a new product called ZAP-CHO , a performance enhancing cell culture media supplement designed to improve cell growth and antibody production in mammalian cell culture. “ZAP-CHO improves CHO product development in chemically defined media that are completely free of animal...

A quicker, cheaper SARS virus detector -- one easily customizable for other targets

... epidemics. It consists of a piece of synthetic antibody attached to a nanowire that's attached to an elect...al base, immersed in liquid. If the protein the antibody binds to is present in the liquid, it will bind to... containing residues randomly distributed over the antibody surface." The Zhou lab, which has specialized i...

Scientists develop a new HIV microbicide -- and a way to mass produce it in plants

...ll of which we address in this study." In the research paper, Ma and colleagues describe how they combined two protein microbicides (b12 monoclonal antibody and cyanovirin-N) into a single "fusion" molecule and showed that this molecule is more active against HIV than either of its individual components. T...

InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO

...utical sector.   ZAP-CHO, a new product from InVitria , enhances performance of mammalian cell culture including improved cell growth and antibody production. It achieves these performance advantages in chemically defined media that are completely free of animal components. Previously, the perfor...

GenWay Biotech obtains exclusive rights to AMDL's DR-70 cancer test in US and Canada

... (San Diego, CA) May 15, 2009 GenWay Biotech, Inc., ( www.genwaybio.com ) a US-based diagnostic company which specializes in providing protein and antibody solutions, announced its partnership with AMDL, Inc., a US-based pharmaceutical company with major operations in China, regarding the distribution of ...

Princeton team's analysis of flu virus could lead to better vaccines

...g this multi-stage interactive process -- known as antibody interference -- to advantage, the scientists belie...l Academy of Sciences . "We have proposed that antibody interference plays a major role in determining the effectiveness of the antibody response to a viral infection," said Ned Wingreen,...

K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses

...he 1918 virus killed more than 20 million people and was lethal to ferrets, mice and macaques. Another surprising finding from the study was the rapid antibody response in the animals infected with the 1918 virus, which is not typically reported for the swine influenza virus. Richt said he plans to conduct...

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

...ck out like spikes from the viral membrane. But an antibody can only bind to two spikes at the same time if th... to stretch its two arms. "When both arms of an antibody are able to bind to a virus at the same time," say...d, as expected, that one-armed versions of the b12 antibody were less effective at neutralizing HIV than two-a...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...mmune stimulating ability of a fully human anti-PS antibody and the other demonstrates the ability of a second fully human anti-PS antibody to stimulate development of a critical component o...rine's anti-PS pipeline. Peregrine's lead anti-PS antibody bavituximab is currently in Phase II clinical tria...

UT Southwestern researchers probe kidney damage, protection in lupus

...rtion of the organ that performs its main function of filtering wastes from blood. They then looked for genes that turned on or off in response to the antibody assault. Nine forms of the kallikrein, or klk, gene became more active, resulting in a two- to sixfold increase in the proteins encoded by the gene...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

...ington, DC - New research suggests that monoclonal antibody therapy of cancer can be improved to be much more ...arch 21 issue of the Lancet . "We believe that antibody therapy has the capacity to immunize people agains...ing the last eight years of research on monoclonal antibody treatment, suggests that a new era in use of these...

Microscope reveals how bacteria 'breathe' toxic metals

...ntibodies for the protein OmcA, which they suspected Shewanella would use to "breathe" the metal. Whenever the probe slid over an OmcA protein, the antibody coating would stick to the protein. By measuring the tiny increase in force needed to pull the two apart, the researchers could tell where on the bact...

A natural approach for HIV vaccine

... neutralizing activity, says Nussenzweig. But each antibody alone has limited ability to fight the virus. "Ind...wn the virus in cell culture as well as any single antibody studied to date. These natural antibodies were als... diversity may be an advantage over a single super antibody that focuses on only one part of the virus, which ...

Twin nanoparticle shown effective at targeting, killing breast cancer cells

...cle. On one end, they attached a synthetic protein antibody to the iron-oxide nanoparticle. On the other end, ...st-cancer cell like a guided missile. The attached antibody is critical, because it binds to the antigen, a pr...article vehicle "docks" on the tumor cell when the antibody and the antigen become connected. Once docked, the...

Antibody key to treating variant CJD, scientists find

...re of the 'binding' between a brain protein and an antibody that could be key to treating patients with diseas...ase. To understand the 'connection' between the antibody and the protein, scientists at Liverpool used X-ra...hree-dimensional picture of the binding between an antibody called ICSM18 designed to 'stick' effectively to ...

Epstein-Barr virus may be associated with progression of MS

...line and three years later. Results showed that higher levels of anti-EBV antibody measured at the beginning of the study were associated with an increased lo...agnosed with MS. The study will investigate the relationship of anti-EBV antibody levels to development of gray matter atrophy, neurocognitive function and d...