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Antibodies in Biological News

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

PASADENA, Calif.--Some 25 years after the AIDS epidemic spawned a worldwide search for an effective vaccine against the human immunodeficiency virus (HIV), progress in the field seems to have effectively become stalled. The reason? According to new findings from a team of researchers from the Cali...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

DENVER, Colorado and TUSTIN, Calif., April 21, 2009--Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and serious virus infections, today reported that two preclinical studies presented during th...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

Washington, DC - New research suggests that monoclonal antibody therapy of cancer can be improved to be much more powerful than it is today, says a researcher at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center in the March 21 issue of the Lancet . "We believe that a...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

February 22, 2009--Researchers at the Dana-Farber Cancer Institute (Dana-Farber), Burnham Institute for Medical Research (Burnham) and the Centers for Disease Control and Prevention (CDC) have reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented range o...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

February 22, 2009--Researchers at the Dana-Farber Cancer Institute (Dana-Farber), Burnham Institute for Medical Research (Burnham) and the Centers for Disease Control and Prevention (CDC) have reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented range o...

Evolution in action: Our antibodies take 'evolutionary leaps' to fight microbes

With cold and flu season in full swing, the fact that viruses and bacteria rapidly evolve is apparent with every sneeze, sniffle, and cough. A new report in the January 2009 issue of The FASEB Journal ( http://www.fasebj.org ), explains for the first time how humans keep up with microbes by rear...

1918 flu antibodies resurrected from elderly survivors

Ninety years after the sweeping destruction of the 1918 flu pandemic, researchers at Monroe Carell Jr. Children's Hospital at Vanderbilt have recovered antibodies to the virus from elderly survivors of the original outbreak. In addition to revealing the surprisingly long-lasting immunity to ...

Presence of certain antibodies signals healthier teeth and gums

ANN ARBOR, Mich.---Antibodies present in people with good oral health could become the first tool for dental professionals to assess a patient's probable response to periodontal disease treatments, say researchers at the University of Michigan. The antibody is to a protein called HtpG, the bug ...

Avian influenza survivors' antibodies effective at neutralising H5N1 strain

Adults who have recovered from the potentially deadly H5N1 strain of avian influenza may hold the key to future treatments for the virus, according to an international team of researchers. In a study published today in the open access journal PLoS Medicine, the researchers have shown how specific ...

Report calls for improved monoclonal antibodies against solid tumors

A new report by leading experts in monoclonal antibody research for oncology offers a conceptual framework for future research in the design of antibody therapies against solid tumors. Writing in the January 15, 2007 issue of CANCER ( http://www.interscience.wiley.com/cancer-newsroom ), a peer-revi...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

Engineering the "Fc" region of monoclonal antibodies (mAbs) increases their toxicity to cancer cells, potentially improving the utility of targeted cancer therapies, according to research conducted at Xencor, which will be published in the March 14 print issue of the Proceedings of the National Aca...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

Researchers at GlycoFi and Dartmouth College have reported the first production of monoclonal antibodies with human sugar structures in yeast. This research, published online January 22 and in the February issue of the journal Nature Biotechnology, demonstrates that antibodies with human sugar s...

Mice studies illustrate potential of chimp/human antibodies to protect against smallpox

Results from a new study indicate that hybrid laboratory antibodies derived from chimpanzees and humans may provide a potentially safe and effective way to treat the serious complications that can occur following smallpox vaccination--and possibly may even protect against the deadly disease itself....

Horse antibodies against the bird flu virus H5N1 are effective as treatment in mice

Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus. A study published today in the open access journal Respiratory Research ( http://respiratory-research.com ) reveals that a dose of 100 µg of horse anti-serum effectively pr...

First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

Chicken-produced antibodies demonstrate enhanced cell killing compared to conventionally produced anti-cancer antibodies Origen Therapeutics today announced the first published scientific report of fully functional, human sequence monoclonal antibodies (mAbs) produced in chickens. The antibodies...

New cancer drug delivery system is effective and reversible

...he cancer drug into the cell. Developing such antibodies is costly and time-consuming, however, and the pro...taching them to liposomes is difficult to control. antibodies spur an immune response, requiring extra steps to ...ng agents, but those now in use are not as good as antibodies at binding to cancer cells. To solve the cell-t...

First human gets new antibody aimed at hepatitis C virus

...nted, researchers hope the HCV virus left in the bloodstream will be neutralized and rendered unable to infect the new liver. Then, because monoclonal antibodies are highly specific and typically have little or no side-effects, additional dosages of the new antibody could, theoretically, be given immediately af...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...t may not pass through the blood-brain barrier, it could possibly be delivered through a viral vector, or administered following brain surgery. While antibodies are used to treat a variety of cancers, such as Herceptin for breast cancer, no antibody treatment has yet been approved for brain diseases, although ...

K-State researcher, collaborators study virulence of pandemic H1N1 virus

...cids or other parts of the virus in a sample, as well as tools for indirect detection. The latter approach is done by creating diagnostics that detect antibodies produced by animals infected with the virus. "We do this work to protect the pig industry in case the virus would jump into the swine population," ...

In vitro antibody production enables HIV infection detection in window period -- key to safer blood

...containing immune potentiating agents promoted the synthesis and release of antibodies against HIV-1 prior to their detection in corresponding plasma samples in a...ppression, in-vitro, led to the production of detectable levels of anti-HIV antibodies in the whole blood sample and to the detection of potentially infectious bl...

EPA grant to University of Chicago for research on food allergy triggers

...million children in the United States." The University of Chicago, in conjunction with Northwestern University, will work to determine why specific antibodies start reacting to foods and allergens when they are eaten. Understanding this process will help determine how food can trigger an allergic response an...

Vaccine blocks malaria transmission in lab experiments

...nd non-human primates for use in a potential transmission-blocking vaccine. antibodies induced by Pfs48/45 protein vaccine effectively blocked the sexual developm...e relative ease of expression and induction of potent transmission-blocking antibodies in mice and non-human primates. This approach provides a compelling rationa...

Penn-Wistar team gains insight into HIV vaccine failure

... had previous immunity in the form of neutralizing antibodies to the adenovirus 5 (Ad5) vector used to deliver t...main immune gatekeeper in most vaccine strategies. antibodies produced in response to previous infection neutral...nothing to indicate that pre-existing neutralizing antibodies correlated with numbers of activated CD4 T-cells t...

LSUHSC's Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia

...the National Institutes of Health to study whether antibodies that recognize carbohydrate (sugars) and proteins ...lier research by Dr. Kolls found that carbohydrate antibodies are part of the natural response to the Pneumocyst...fungus. Theses preliminary studies show that these antibodies participate in early clearance of the organism fro...

Virus-resistant grapevines

...ies," explains Dr. Stefan Schillberg, head of department at the IME. "These antibodies 'recognize' the viruses and prevent them from spreading in the plant and ca...entists have to modify its genotype and channel genetic information for the antibodies into it. This task is performed by tiny helpers called agrobacteria, which ...

UT scientist receives hemophilia research award

...e resistant to replacement Factor VIII and produce antibodies that attack the synthetic protein. "Current therapies to treat these antibodies are expensive and often unsuccessful," Smith said....hat trigger the production of the anti-Factor VIII antibodies in people with Hemophilia A, which in turn would m...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... third subgroup was comprised mostly of younger patients (average age 7) who had no clearly defined gene expression signature and did have antinuclear antibodies (ANA). This third subgroup may be more similar to oligoarthritis patients, who frequently have a positive ANA, than to the other subgroups of polyarti...

Major breakthrough in early detection and prevention of AMD

... in the living eyes of mice by attaching anti-CCR3 antibodies to tiny semiconductor nanocrystals called "quantum dots" and injecting these into the mice. The antibodies cause the quantum dots to attach to CCR3 on the su... blood vessels in the eye. Thus the same anti-CCR3 antibodies used to detect CNV could potentially be useful as ...

New device detects heart disease using less than one drop of blood

... Northeastern University in Boston. To collect the cells, the device works similar to Velcro or a magnet. Specifically, the inside is coated with antibodies that only bind to endothelial progenitor cells. Blood flows through the device through a funnel-like opening (except the blood enters through the narr...

Protein identified as critical to insulating the body's wiring could also become treatment target

...a potential new site for targeted cancer therapy, says Dr. Yanmei Tao says, postdoctoral fellow in neurobiology and the study's first author. In fact, antibodies to ErbB2 already are available to patients with breast and prostate cancers. For nerves to communicate with each other or another cell type, such...

Novel vaccine approach offers hope in fight against HIV

...rs away from realization. Most attempts at developing an HIV vaccine have used substances aimed at stimulating the body's immune system to produce antibodies or killer cells that would eliminate the virus before or after it infected cells in the body. However, clinical trials have been disappointing. HIV va...

Glutamine supplements show promise in treating stomach ulcers

...roup.) The mice were then followed for a 20-week period, during which time samples of blood and stomach tissue were removed. Blood was analyzed for antibodies to specific types of T-helper immune cells, which mediate the body's response to H. pylori infection. Stomach tissues were examined for evidence of ...

MIT’s implantable device offers continuous cancer monitoring

... chorionic gonadotropin, a hormone produced by human tumor cells. The cylindrical, 5-millimeter implant contains magnetic nanoparticles coated with antibodies specific to the target molecules. Target molecules enter the implant through a semipermeable membrane, bind to the particles and cause them to clump t...

Princeton team's analysis of flu virus could lead to better vaccines

...those naturally produced defensive proteins called antibodies that fight infection. By manipulating this multi-s...acks a human, the body mounts a defense, producing antibodies custom-designed to attach themselves to the virus,...Ndifon noticed a perplexing pattern. He found that antibodies were often better at protecting against a slightly...

Molecules that orchestrate the processes of life

... Imagine that we had some way to look directly at the molecules in a living organism.Think of the wonders we could witness firsthand: antibodies attacking a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA... The Machinery of Life is a journey into th...

Novel antibody prevents infection by hepatitis C virus

...d then painstakingly searched for individual human antibodies produced in the mice that would recognize and bind... known as the glycoprotein. Once they found human antibodies that looked promising, they evaluated in vitro the ability of those antibodies to neutralize the virus and selected a lead candid...

Avian flu research sheds light on swine flu outbreak

...e HA surface protein, one of the sites where human antibodies created in response to current vaccines would bind...ight against the virus. The immune system produces antibodies against the vaccine that remain in the system unti...lar one is later introduced into the system, those antibodies attach to viral particles and remove them before t...

Findings uncover new details about mysterious virus

...entists in 1992 but wasn't confirmed to be a virus until 2003. The virus infects amoebas, but it is thought to possibly be a human pathogen because antibodies to the virus have been discovered in pneumonia patients. However, many details about the virus remain unknown, said Michael Rossmann, Purdue Universit...

American Chemical Society's Weekly PressPac -- April 22, 2009

... available for five of the six known species of Listeria . These tests use antibodies that signal the presence of the bacteria. However, no rapid, sensitive test...ock proteins which the body produces in response to stress instead of the antibodies used in other tests. They showed that their new sensor was faster and more ...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

...lso known as MDX-066/MDX-1388 and MBL-CDA1/MBL-CDB1) are novel, fully human antibodies that were developed by MBL and Medarex to target and neutralize the effects...risk for CDI have shown a positive correlation between detectable levels of antibodies in the blood to both toxins A and B and protection from disease or relapse....
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