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Antibiotics in Biological News

Class of antibiotics can enhance gene-silencing tool

A way to turn off one gene at a time has earned acceptance in biology laboratories over the last decade. Doctors envision the technique, called RNA interference, as a tool to treat a variety of diseases if it can be adapted to humans. Emory University researchers have discovered that antibiotic...

High degree of resistance to antibiotics in Arctic birds

In the latest issue of the journal Emerging Infectious Diseases, Swedish researchers report that birds captured in the hyperboreal tundra, in connection with the tundra expedition Beringia 2005, were carriers of antibiotics-resistant bacteria. These findings indicate that resistance to antibiotic...

Manure management reduces levels of antibiotics and antibiotic resistance genes

MADISON, WI, November 26, 2007- Antibiotic resistance is a growing human health concern. Researchers around the globe have found antibiotics and other pharmaceuticals to be present in surface waters and sediments, municipal wastewater, animal manure lagoons, and underlying groundwater. In a recent...

Alternative methods proposed to detect pesticides and antibiotics in water and natural food

Water or food of natural origins (from plants or animals) that we consume on a daily basis can contain unwanted supplies for our organism, such as pesticides or antibiotics. A doctoral thesis carried out by Jorge Juan Soto Chinchilla, from the Department of Analytical Chemistry Department of Anal...

Pinhead-size worms + robot = new antibiotics

In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics. Their study appeared in ACS Chemical Biology , a monthly journal. Frederick Ausu...

Munich researchers discover new target for tailored antibiotics

This release is available in German . More and more strains of bacteria are developing resistance to previously life-saving antibiotics. Researchers at TUM, the Technische Universitaet Muenchen, have shed light on a metabolic step that appears in many aggressive microorganisms -- such as t...

Biological warfare in bacteria offers hope for new antibiotics

Scientists are to study a group of proteins that are highly effective at killing bacteria and which could hold the key to developing new types of antibiotics. Researchers from the Universities of York and Leeds have been awarded 3.3m from the Biotechnology and Biological Sciences Research Counc...

Newly discovered reactions from an old drug may lead to new antibiotics

A mineral found at health food stores could be the key to developing a new line of antibiotics for bacteria that commonly cause diarrhea, tooth decay and, in some severe cases, death. The trace mineral selenium is found in a number of proteins in both bacterial cells and human cells called sele...

Genetic switch potential key to new class of antibiotics

Researchers have determined the structure of a key genetic mechanism at work in bacteria, including some that are deadly to humans, in an important step toward the design of a new class of antibiotics, according to an accelerated publication that appeared online today as a "paper of the week" in t...

Groundbreaking discovery may lead to stronger antibiotics

CHARLOTTESVILLE, Va., Oct. 1, 2008 The last decade has seen a dramatic decline in the effectiveness of antibiotics, resulting in a mounting public health crisis across the world. A new breakthrough by University of Virginia researchers provides physicians and patients a potential new approach to...

New way to make malaria medicine also first step in finding new antibiotics

University of Illinois microbiology professor William Metcalf and his collaborators have developed a way to mass-produce an antimalarial compound, potentially making the treatment of malaria less expensive. Metcalf set out to understand how this compound, one of a group known as phosphonates,...

Milk may help bacteria survive against low levels of antibiotics

Milk may help prevent potentially dangerous bacteria like Staphylococcus from being killed by antibiotics used to treat animals, scientists heard today (Monday 8 September 2008) at the Society for General Microbiology's Autumn meeting being held this week at Trinity College, Dublin. Bacteria so...

Energy-saving bacteria resist antibiotics

Bacteria save energy by producing proteins that moonlight, having different roles at different times, which may also protect the microbes from being killed. The moonlighting activity of one enzyme from the tuberculosis bacterium makes it partially resistant to a family of broad-spectrum antibiotic...

UIC scientists discover how some bacteria survive antibiotics

Researchers at the University of Illinois at Chicago have discovered how some bacteria can survive antibiotic treatment by turning on resistance mechanisms when exposed to the drugs. The findings, published in the April 24 issue of the journal Molecular Cell, could lead to more effective antibioti...

Unique fungal collection could hold key to future antibiotics

Royal Holloway and CABI both bring a combination of individual scientific skills, expertise and resources to the project. When brought together, these offer the opportunity to build a highly focused natural products drug discovery operation that will address the urgent need for bringing new antibi...

UIC researchers find promising new targets for antibiotics

University of Illinois at Chicago researchers have identified new sites on the bacterial cell's protein-making machinery where antibiotics can be delivered to treat infections. "The primary challenge of antibiotic therapy has been fighting infections caused by the pathogens which became resista...

Natural antibiotics yield secrets to atom-level imaging technique

Frog skin and human lungs hold secrets to developing new antibiotics, and a technique called solid-state NMR spectroscopy is a key to unlocking those secrets. That's the view of University of Michigan researcher Ayyalusamy Ramamoorthy, who will discuss his group's progress toward that goal March...

Study finds antibiotic resistance in poultry even when antibiotics were not used

A surprising finding by a team of University of Georgia scientists suggests that curbing the use of antibiotics on poultry farms will do little ?if anything ?to reduce rates of antibiotic resistant bacteria that have the potential to threaten human health. Dr. Margie Lee, professor in the UGA Co...

Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates

A study published today in the Journal of Antimicrobial Chemotherapy1 provides the best available evidence that cases of Clostridium difficile infection (CDI)---one of the most common and increasing types of hospital-acquired infection---can be reduced in hospital wards if doctors prescribe narrow-...

Controlling antibiotics and antibiotic resistance in hospitals

In one of the first national studies on guidelines that control antibiotics and antibiotic resistance in hospitals, researchers from the Indiana University School of Medicine, the Regenstrief Institute, Inc. and the Richard Roudebush Veterans Administration Medical Center report that hospitals that...

Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax

Anthrax vaccine administered in combination with a short course of antibiotics completely protected nonhuman primates from inhalational anthrax, the most lethal form of the disease, according to scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). In a collab...

Over-use of antibiotics in fish-for-food industry encourages bacterial resistance and disease

The heavy use of antibiotics in the rearing of fish could be detrimental to the health of the fish, but also that of animals and humans, a recent report says. This practice encourages bacterial resistance and could lead to the evolution of resistant strains of bacteria in animals and humans as well...

Children overprescribed antibiotics for sore throat

Physicians prescribe antibiotics for more than half of children with sore throat, exceeding the expected prevalence of strep throat, and used nonrecommended antibiotics for 27 percent of children who received an antibiotic prescription, according to a study in the November 9 issue of JAMA. Pharyn...

New class of antibiotics effective against drug-resistant bacteria discovered in fungi

What happened to the chicken when she crossed the road is less important that what happens to what she eats when it is used as fertilizer. Organic arsenic is fed to poultry to prevent bacterial infections and improve weight gain. A little bit of arsenic is taken up by the tissue and the majority ...

Researchers find how some antibiotics kill bacteria

Researchers have uncovered how members of one family of antibiotics kill bacteria that make people sick. This new knowledge may help drug developers make slight changes to these antibiotics to make them more effective against drug-resistant strains of bacteria, said Irina Artsimovitch, a study c...

Use of Antibiotics for Acne May Increase Risk of Common Illness

Novel use of genetic testing methods helped public health officials control and limit the further spread of four outbreaks of foodborne hepatitis A virus in 2003 related to the consumption of green onions, according to a detailed analysis published in the October 15 issue of The Journal of Infectio...

Doctors should stop prescribing antibiotics for the common cold, review advises

Antibiotics should not be prescribed to patients with the common cold because there is scant evidence they stop other infections, and the benefits do not outweigh the risks, according to a new systematic review of current evidence. "Antibiotics appear to have no benefit in the treatment of acute ...

Unusual antibiotics show promise against deadly 'superbugs'

Altered protein could help deliver drugs and shape the growth of engineered tissueCollagen often pops up in beauty products and supermodel lips. But by mating collagen with a molecular hitchhiker, materials scientists at Johns Hopkins hope to create some important medical advances. The researchers ...

Research on antibiotics receives historical recognition

Research leading to the discovery of streptomycin ?the first effective pharmaceutical treatment for tuberculosis ?will be designated a National Historic Chemical Landmark at Rutgers University in a special ceremony in New Brunswick, New Jersey, on May 24. The American Chemical Society, the world's ...

Test helps in fight against lung infections and for treating other life-threatening infections

...llow doctors to more accurately identify the right antibiotics required to treat serious, chronic infections that...nt of chronic infections required trying different antibiotics until one or several together eliminated or contro...ilm infections can be 1000 times more resistant to antibiotics than conventional infections. Now, for the firs...

C. difficile spores spread superbug

...two weeks after cessation of the treatment. But after long term exposure to antibiotics some of the mice remained in their 'supershedder' state for weeks or even l...tal contamination is a potential infection threat. The administration of antibiotics has been a known risk factor in the development of C. difficile infection...

A matter of density, not quantity

...they reach a certain density, colonies of Pseudomonas aeruginosa produce virulence factors and can enter into a slimy state, a biofilm, which prevents antibiotics from penetrating. The process of quorum sensing, which cells use to "sense" cell density, is triggered when the concentration of certain signaling com...

Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax

...." Raxibacumab represents a new way to address the anthrax threat. While antibiotics can kill the anthrax bacteria, they are not effective against the deadly to...e toxins already are circulating in their blood, and it may be too late for antibiotics alone to be effective. "We are very proud that the importance of these ...

U Alberta researcher in same group as Darwin and Hawking

... may have potential for human use, such as combating hospital-acquired infections. Peptides are 1,000 to 1 million times more active than conventional antibiotics and are effective against infectious bacteria resistant to commonly used antibiotics. Currently, more than 50 per cent of hospital-acquired infections...

New national genome center launched

...anisms and the genetic differences that exist between individuals. This knowledge can then be used for developments that include the production of new antibiotics to fight 'superbugs', breeding of new crops with increased tolerance of drought, and the breeding of livestock better able to resist emerging exotic ...

Singapore nanotechnology combats fatal brain infections

...blood brain barrier offers a superior alternative to existing treatments for brain infections. The brain membrane is impenetrable to most conventional antibiotics because the molecular structure of most drugs is too big to enter the membrane. "Our treatment damages the structure of the pathogen and literally...

Antibiotics take toll on beneficial microbes in gut

...bacteria normally floats in our intestinal tracts. antibiotics at least temporarily disturb the normal balance. But it's unclear which antibiotics are the most disruptive, and if the full array of ...own for the first time that two different types of antibiotics can cause moderate to wide-ranging changes in the ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

...in the study of these important enzymes," Sobrado said. "If we can learn how it functions, we can perhaps identify inhibitors that can be developed as antibiotics or antifungal agents," he said. "Since humans do not have siderophores, an inhibitor should not be toxic to us." Using modern biology techniques, S...

Plant microbe shares features with drug-resistant pathogen

...team provided the data on the plant-dwelling strain. For one thing, the scientists found genes that make the bacteria resistant to a wide range of antibiotics in both strains. "This suggests that antibiotic resistance is part of the species' core genome, and not a trait acquired in the hospital," van der Lel...

Researchers describe 'implausible' chemistry that produces herbicidal compound

...edicine. This class of compounds includes the herbicide glyphosate, the osteoporosis treatment alendronate, the antimalarial drug fosmidomycin and the antibiotics fosfomycin, dehydrophos and plumbemycin. Whether man-made or naturally produced, phosphonates and phosphinates are structurally similar to other ...
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