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Aggressive in Biological News

Possible drug target found for one of the most aggressive breast cancers

Grand Rapids, Mich. (July 8, 2009) Van Andel Research Institute (VARI) investigators have identified a gene that could be an important therapeutic target in the treatment of the most aggressive forms of breast cancer. Currently, patients with these cancers have few treatment options. "Breast...

Agent Orange exposure increases veterans' risk of aggressive recurrence of prostate cancer

AUGUSTA, Ga. - Veterans exposed to Agent Orange are at increased risk of aggressive recurrence of prostate cancer, researchers report. A study of 1,495 veterans who underwent radical prostatectomy to remove their cancerous prostates showed that the 206 exposed to Agent Orange had nearly a 50 pe...

Researchers identify genetic markers for aggressive head and neck cancer

March 18, 2009 (BRONX, NY) Scientists at Albert Einstein College of Medicine of Yeshiva University have identified genetic markers that signal poor outcomes for patients with head and neck cancer. These findings could one day lead to a genetic test that could help select or predict successful tr...

Researchers identify gene linked to aggressive progression of liver cancer

RICHMOND, Va. (Feb. 17, 2009) Virginia Commonwealth University researchers have identified a gene that plays a key role in regulating liver cancer progression, a discovery that could one day lead to new targeted therapeutic strategies to fight the highly aggressive disease. Hepatocellular carc...

UC Davis researchers discover a key to aggressive breast cancer

(SACRAMENTO, Calif.) In trying to find out why HER2-positive breast cancer can be more aggressive than other forms of the disease, UC Davis Cancer Center researchers have surprisingly discovered that HER2 itself is the culprit. By shutting down its own regulator gene, HER2 creates a permissive en...

International team reveals first prognosticator of survival in aggressive cancer

(Philadelphia, PA September 4, 2008) The tumor suppressor gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS), according to an international collaboration of researchers, including scientists at the Sbarro Institute for Cancer Research and M...

Dense tissue promotes aggressive cancers

New research may explain why breast cancer tends to be more aggressive in women with denser breast tissue. Breast cancer cells grown in dense, rigid surroundings step up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 issue of Current Biology . The...

Estrogen helps drive distinct, aggressive form of prostate cancer

NEW YORK (May 27, 2008) -- Using a breakthrough technology, researchers led by a Weill Cornell Medical College scientist have pinpointed the hormone estrogen as a key player in about half of all prostate cancers. Estrogen-linked signaling helps drive a discrete and aggressive form of the diseas...

University of Minnesota study refutes belief that black men have more aggressive prostate cancer

A University of Minnesota study of prostate cancer tumors from Caucasian and African-American men has shown no evidence that the cancer is more aggressive in black men. Lead investigator Akhouri Sinha, a professor of genetics, cell biology, and development and research scientist at the Minneapolis...

Selective marker found to indicate aggressive form of breast cancer

Researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment. In the January 15 issue of Cancer Research, researchers from Dartmouth Medical School demonstrate that...

'Tribbles' protein implicated in common and aggressive form of leukemia

Researchers at the University of Pennsylvania School of Medicine have identified a new protein associated with acute myelogenous leukemia (AML). Several lines of evidence point to a protein called Tribbles, named after the furry creatures that took over the starship Enterprise in the original Star ...

Adolescent but not adult hamsters are more aggressive on low dose of fluoxetine

New research offers tantalizing clues as to why some teenagers taking common anti-depressants may become more aggressive or kill themselves. The research is published in the October Behavioral Neuroscience, which is published by the American Psychological Association (APA). Neuroscientists at th...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

Accentia Biopharmaceuticals, Inc. report follow-up data to a Phase 2 trial conducted by the National Cancer Institute (NCI) that shows Biovest's BiovaxID yielded an 89% survival rate in mantle cell lymphoma patients. The median follow-up was 3.8 years. Historically, patients with this type of l...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

Nerves talk to each other using chemicals called neurotransmitters. One of those "communication chemicals," aptly named GABA (gamma amino butyric acid), shows up in unusually high amounts in some aggressive tumors, according to a new study from Washington University School of Medicine in St. Louis....

Chromosome Deletion Predicts Aggressive Neuroblastoma

When genes are deleted on a particular section of chromosome 11, the result is an aggressive form of the childhood cancer neuroblastoma. A new study suggests that detecting this genetic deletion during the initial evaluation of children with neuroblastoma may indicate to physicians that they should...

Protein handlers should be effective treatment target for cancer and Alzheimer's

...lso are cross breeding the mice, to create one, for example, that also over expresses the molecule, Her2/Neu, which is over active in some of the most aggressive breast cancers. By comparing the resulting mouse to one that just over expresses Her2/Neu, they can examine the impact of Hsf1, Dr. Mivechi says. ...

La Jolla Institute discovers novel tumor suppressor

..." Dr. Kawakami continued. Dr. Kawakami said his research team got similar results in tests of human cells from people with Burkitt's lymphoma, an aggressive type of B-cell lymphoma that occurs most often in children and young adults. "Some Burkitt's lymphoma cells have very little PLC-beta 3 expression an...

Stem cell 'daughters' lead to breast cancer

...in 10-20 per cent of women with hereditary breast cancer. Women with BRCA1 mutations often develop 'basal-like' breast cancer, which is a particularly aggressive form of the disease. A team led by Associate Professors Jane Visvader and Geoff Lindeman from the institute's Victorian Breast Cancer Research Cons...

Family planning a major environmental impact

...inue to increase as they seek higher standards of living," Murtaugh said. The study examined several scenarios of changing emission rates, the most aggressive of which was an 85 percent reduction in global carbon emissions between now and 2100. But emissions in Africa, which includes 34 of the 50 least devel...

Study links virus to some cases of common skin cancer

...hed in a recent issue of the Journal of Investigative Dermatology . The virus was first discovered in patients with Merkel cell carcinoma, a rare, aggressive skin cancer that occurs mainly in the elderly and people with a suppressed immune system. The people in the new study all had a healthy immune system....

A crystal ball for brain cancer?

...cent accuracy which patients' tumors were the least likely to grow six months after therapy. Bronnie McNabb, 57, considers himself lucky. When his aggressive brain cancer returned after chemotherapy and radiation, his UCLA doctor prescribed the off-label use of Avastin, a drug shown to quell cancers in the ...

Test helps in fight against lung infections and for treating other life-threatening infections

...fections place a major cost burden on the health system. Patients spend more time in hospitals, antibiotic costs and treatment costs increase as more aggressive treatment options are explored, and the potential always exists for these infections to cause death. Until bioFILM PA™, treatment of chronic ...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...mphoma patients, making it a good candidate for the screening, says Dr. Shi who also is looking for these types of biomarkers in breast cancer and the aggressive adult brain tumor glioblastoma. Dr. Robertson, who also works in breast cancer and brain tumors as well as colon cancer, is finding patterns of gen...

URI researcher sheds light on 'man-eating' squid; finds them timid, nonthreatening

...iving in waters where the squid are found. Many also encourage the squid's aggressive behavior by chumming the waters. I didn't believe the hype, but there was ...d use caution. "However, I want to spread the word that they aren't the aggressive man-eaters as they have been portrayed," Seibel said. ...

Improved air quality during Beijing Olympics could inform pollution-curbing policies

... The air in Beijing during the 2008 Olympics was cleaner than the previous year's, due to aggressive efforts by the Chinese government to curtail traffic, increase emissions standards and halt construction in preparation for the games, according to a ...

URI researcher sheds light on 'man-eating' squid; finds them timid, non-threatening

...iving in waters where the squid are found. Many also encourage the squid's aggressive behavior by chumming the waters. I didn't believe the hype, but there was ...d use caution. "However, I want to spread the word that they aren't the aggressive man-eaters as they have been portrayed," Seibel said. ...

Genetic marker linked to problem behaviors in adults with developmental disabilities

...ty's Peabody College of education and human development, said. "This research suggests one way we might predict which individuals are at risk of being aggressive and destructive and provide treatment before problems occur." Fifteen to 20 percent of adults with developmental/intellectual disabilities have pro...

Munich researchers discover new target for tailored antibiotics

...previously life-saving antibiotics. Researchers at TUM, the Technische Universitaet Muenchen, have shed light on a metabolic step that appears in many aggressive microorganisms -- such as tuberculosis and malaria pathogens -- and that may provide a promising target for a new class of antibiotics. The researcher...

Report shows the power of US cities to mitigate climate change and steps they need to take to adapt

...ecent estimates by scientists that emissions need to be reduced by 80% by 2050, the report finds these early steps to be promising, but that continued aggressive action is necessary over the next 40 years to meet the scale of the challenge. ...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

...s work opens an important window into the mystery of why patients with lung fibrosis suddenly decompensate and how to identify these patients for more aggressive therapies," said Mark T. Gladwin, M.D., chief of Pitt's Division of Pulmonary, Allergy and Critical Care Medicine. "Our current research efforts in th...

Colorectal cancer

...ntified 115 genes that are disregulated both in the primary tumor and in its metastases. In the future, their findings may help identify patients with aggressive tumors at an earlier stage ( Gastroenterology 2009, doi:10.1053/j.gastro.2009.03.041).* The National Cancer Institute estimates that, alone in the...

A thirst for blood sparks toxic algal blooms

... article published in the journal PNAS that algal blooms are created when aggressive algae kill and injure their competitors in order to absorb the nutrients th...at previous research had found is only a side-effect of a considerably more aggressive behaviour: toxic algae injure or kill competing algae in order to gain acce...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... better ways to classify, predict outcome, and treat juvenile idiopathic arthritis (JIA). Eventually such findings could enable doctors to target more aggressive treatment to children at risk of more severe arthritis, while those likely to have milder disease could be spared the stronger treatments that carry a...

The faster they come

...nate fish have to escape quickly and often, or that slower fish become more aggressive because they cannot manoeuvre quickly." The researchers also analysed wheth...y affect the social position of a given individual, and found that, indeed, aggressive behaviours tend to decline as fin damage sustained in fights accumulates. I...

Evolution of a contraceptive for sea lamprey

... sharks, fish and land vertebrates, lampreys have no jaw. They feed on fish by attaching themselves to the fish and sucking their body fluids. Their aggressive consumption of game fish has eliminated many natural predators of the alewife, another invasive species on the Great Lakes. This has allowed the alew...

Prostate Cancer Translational Research in Europe meeting: Search for biomarkers continues

...genetic risk models do not predict who will get progressive disease. Promark, another consortium, searches for genetic variants that do associate with aggressive cancer forms. She also noted that the information on PSA genetics may improve utility in screening. Rafnar also pointed out that although "...much w...

Research uncovers clues to virus-cancer link

...y stages of tumor progression. They found that certain miRNAs were lost as the tumors progressed, effectively accelerating the cancer's growth. More aggressive tumor stages expressed higher levels of KSHV miRNA. In second study, published June 4 in the journal Blood, the team looked for the presence of tum...

GARP makes the difference

... was a substantial advance for medicine: the transplant-rejecting T cells developed permanently into Tregs those cells that inhibit the activation of aggressive T cells and thus prevent organ rejection. Furthermore, the researchers also furnished the counter evidence: Michael Probst-Kepper muted the GARP gene ...

Not 1, but 2 kinds of males found in the invasive round goby

... Lakes, which may provide answers as to how they rapidly reproduce. The research, published in the Journal of Great Lakes Research , looks at the aggressive round goby, a bottom-dwelling fish which infested the Great Lakes watersheds around 1990. Presently, they are working their way inland through rivers...

Tracking down the causes of multiple sclerosis

...opment of multiple sclerosis and that particularly aggressive T cells are activated by different proteins. Furth...orm disease through its antibody attacks. More aggressive than others Even if B cells play a far more si...of the autoreactive T cells are significantly more aggressive than others. One group of these 'special' T cells ...
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