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New drug agent knocks out multiple enzymes in cancer pathway

A team of 24 researchers from the U.S., Europe, Taiwan and Japan and led by University of Illinois scientists has engineered a new anti-cancer agent that is about 200 times more active in killing tumor cells than similar drugs used in recent clinical trials. The study appears this week in the ...

Exposure to Agent Orange linked to prostate cancer in Vietnam veterans

(SACRAMENTO, Calif.) UC Davis Cancer Center physicians today released results of research showing that Vietnam War veterans exposed to Agent Orange have greatly increased risks of prostate cancer and even greater risks of getting the most aggressive form of the disease as compared to those who we...

Contrast agent trials in swine

This release is available in German . Mammography continues to be the method of choice for the early detection of breast cancer. However, because this technique is not as selective or specific as one would wish, and does not deliver reliable results for every level of tissue density, altern...

UF researchers develop improved gene therapy agent

GAINESVILLE, Fla. Replacing one amino acid on the surface of a virus that shepherds corrective genes into cells could be the breakthrough scientists have needed to make gene therapy a more viable option for treating genetic diseases such as hemophilia, University of Florida researchers say. Re...

Clot-dissolving agent may be beneficial in treatment of severe frostbite

A preliminary study suggests that a blood clot-dissolving medication that is administered to some patients following a stroke or heart attack may help to reduce the risk of amputation following severe frostbite, according to a report in the June issue of Archives of Surgery, one of the JAMA/Archiv...

'Failed' experiment yields a biocontrol agent that doesn't trigger antibiotic resistance

MADISON - A failed experiment turned out to be anything but for bacteriologist Marcin Filutowicz. As he was puzzling out why what should have been a routine procedure wouldn't work, he made a discovery that led to the creation of a new biological tool for destroying bacterial pathogens - one that...

'Trojan Horse' agent halts bone metastasis in mice

A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread. ...

Chemical warfare agent detection technology used to treat lung disease

A new technique based on the same technology used to detect chemical warfare agents and explosives is being employed by scientists at The University of Manchester to treat hospital patients with lung disease. Dr Paul Thomas and a team of researchers are using a sensor, commonly used to detect exp...

Mouse study: New muscle-building agent beats all previous ones

The Johns Hopkins scientists who first created "mighty mice" have developed, with pharmaceutical company Wyeth and the biotechnology firm MetaMorphix, an agent that's more effective at increasing muscle mass in mice than a related potential treatment for muscular dystrophy now in clinical trials. ...

New cancer drug delivery system is effective and reversible

... CHAMPAIGN, Ill. For cancer drug developers, finding an agent that kills tumor cells is only part of the equation. The drug must also spare healthy cells, and ideally its effects will be reversible, to cut shor...

Scientists uncork a potential secret of red wine's health benefits

... a potential novel therapy to help in the treatment of strong acute inflammatory diseases." In this study, researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pretreated with resveratrol exper...

K-State researcher, collaborators study virulence of pandemic H1N1 virus

... zoonotic diseases and we can contribute by working on models for animal and human diseases," Richt said. "This expertise is very critical now that an agent causing a pandemic flu in humans most likely originated in animal populations." At K-State, Richt is leading in vitro research to develop better te...

Leicester research paves way for first use in Europe of an insect to fight invasive plant

...otweed plants, which severely affect the morphology and vigour of the plant. Dr Shaw added: "Since there has never been a release of a biocontrol agent for a plant species in Europe, extreme caution is being exercised by all concerned". The proposed organism has now satisfied the scientific community...

'Corrective genes' closer thanks to enzyme modification

...se, that our intervention allowed the heart of the enzyme to increase its mobility. This unusual mobility caused the enzyme to resist the chemotherapy agent methotrexate a result we never predicted and one that offers promise." The research team made its discovery as it sought ways to help correct gene...

Nanodiamonds deliver insulin for wound healing

... group also has studied nanodiamonds for applications in cancer therapy. They demonstrated that nanodiamonds are capable of releasing the chemotherapy agent Doxorubicin in a sustained and consistent manner. (Ho is a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.) I...

C. difficile spores spread superbug

...ection. The alcohol-based disinfectants tested had no success in preventing transmission. Instead, a 20-minute surface disinfection using a sporicidal agent was necessary to reduce environmental spore contamination enough to eliminate transmission. Further results detailing the success of individual hospit...

The tiny difference in the genes of bacteria

...nking water or sea water can cause severe human diseases. One of them are vibrios: its species Vibrio cholerae is more commonly known as the causative agent of Cholera that spread in Europe until the 20th century. Interestingly, not all Vibrio cholerae strains are pathogenic to humans. Only those strains c...

GUMC discovery highlights new direction for drug discovery

...he intrinsic activity of a single protein, but our agent stops two proteins from interacting. This has neve... flexible for a drug to bind to. They tested the agent in laboratory cell culture, and with the help of G...nimal models of Ewing's sarcoma and found that the agent significantly inhibited the growth of tumors. Ther...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

...noclonal antibody that since 1998 has been used successfully to treat patients with metastatic breast cancer. This was the first targeted therapeutic agent developed on the basis of a newly discovered gene with an oncogenic function in human cancer. In the early 1990s, Ullrich identified the signaling ...

The tiny difference in the genes of bacteria

...nking water or sea water can cause severe human diseases. One of them are vibrios: its species Vibrio cholerae is more commonly known as the causative agent of Cholera that spread in Europe until the 20th century. Interestingly, not all Vibrio cholerae strains are pathogenic to humans. Only those strains c...

New MRI technique could mean fewer breast biopsies in high-risk women

...out a half hour, the technician injects a contrast agent into a vein in the patient's arm. Over time, the contrast agent flows throughout the body, including the breasts. ... often have immature vasculature, and the contrast agent flows in and "leaks" out quickly. Conversely, beni...

Toxic molecule may help birds 'see' north and south

...must be present at low concentrations but not too low "to make the biochemical compass work effectively," he said. Although known primarily as an agent of aging and cellular damage, superoxide recently has been recognized for its role in cellular signaling. However, its toxicity may also explain wh...

Green tea may affect prostate cancer progression

...ive compounds in green tea demonstrated a significant reduction in serum markers predictive of prostate cancer progression. "The investigational agent used in the trial, Polyphenon E (provided by Polyphenon Pharma) may have the potential to lower the incidence and slow the progression of prostate can...

CU-Boulder study shows Maya intensively cultivated manioc 1,400 years ago

... can be stored almost indefinitely, and traditionally was used by indigenous people in the region for making tamales and tortillas and as a thickening agent for stews, he said. Since indigenous peoples in tropical South America use manioc today to brew alcoholic beverages, including beer, the CU-Boulder...

Researchers from around the globe coming to K-State June 21 for workshop on Fusarium fungus

...cy of the fungus lies in the diseases that it causes and because it produces mycotoxins, a couple of which are on the U.S. federal government's select agent list. "Mycotoxin levels often are included in trade agreements on grain and farmers can get docked at the elevator if the contamination level is to...

Scientific evidence of health problems from past contamination of drinking water at Camp Lejeune is limited and unlikely to be resolved with further study

...s of insufficient quantity, quality, or inconclusive in results to make an informed assessment, but that an association between exposure to a specific agent and a health outcome cannot be ruled out. A summary of the conclusions drawn from the epidemiologic studies related to solvent exposure can be found ...

Rutgers research tackles childhood epilepsy

...treating tuberous sclerosis complex (TSC), a subtype of cortical dysplasia. "We demonstrated that rapamycin is a novel and effective anti-epileptic agent that suppresses seizures in our mice, as well as in the TSC model, and this has raised some hope for the future," said D'Arcangelo. "This drug is bein...

Old stain in a new combination

...e University of Heidelberg. Methylene blue prevents transmission to mosquitoes The appropriate component for such an alternative is a proven agent the methylene blue stain which has been given to malaria patients since the end of the 19th century has proven to be safe, well tolerated, and effect...

Yale team identifies key to potential new treatment for allergy-induced asthma

...the lung by the inflammatory cells responsible for asthma symptoms such as wheezing and mucus overproduction," Jordt explained. The pharmacological agent observed in this study to diminish asthmatic symptoms in mice was identified by Hydra Biosciences. Yale's Sven-Eric Jordt serves on Hydra's scientific...

Diuscovery in amber reveals ancient biology of termites

...first begins to form as sap oozing from a tree, amber has the unique ability to trap very small animals or other materials and as a natural embalming agent display them in nearly perfect, three-dimensional form millions of years later. This phenomenon has been invaluable in scientific and ecological rese...

Skin color clue to nicotine dependence

...us research shows that nicotine has a biochemical affinity for melanin. Conceivably, this association could result in an accumulation of the addictive agent in melanin-containing tissues of smokers with greater amounts of skin pigmentation. "The point of the study is that, if in fact, nicotine does bind...

New technology shows promise against resistant staph infections

... at Albert Einstein College of Medicine of Yeshiva University have combined their revolutionary new drug-delivery system with a powerful antimicrobial agent to treat potentially deadly drug-resistant staph infections in mice. The study is published this month in the online version of the Journal of Invest...

Aware, Inc. Announces Final Results of Dutch Auction Tender Offer

...ommon stock will be issued and outstanding. Georgeson Securities Corporation acted as the dealer manager for the tender offer and the information agent was Georgeson Inc. About Aware, Inc. Aware is a leading technology supplier for the telecommunications and biometrics industries. For more t...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

...demonstrated synergistic activity against the recurrence of lung tumors. Moreover, in a therapeutic cancer vaccine model, MIS administered as a single agent significantly induced an anti-tumor cellular immune response without the reintroduction of previously harvested tumor antigens. This successful induct...

Aware, Inc. Amends and Extends Dutch Auction Tender Offer

... and officers, the dealer manager, the information agent or the depositary makes any recommendation to stoc...r manager for the tender offer and the information agent is Georgeson Inc. Any stockholder who has question...tender offer materials may contact the information agent at (800) 262-0158. Banks and brokerage firms may c...

Aware, Inc. Announces Preliminary Results of Dutch Auction Tender Offer

...on is acting as the dealer manager for the tender offer and the information agent is Georgeson Inc. For questions and information about the tender offer, please call the information agent toll-free at (800) 262-0158. About Aware, Inc. Aware is a leading ...

Agent Orange exposure increases veterans' risk of aggressive recurrence of prostate cancer

... AUGUSTA, Ga. - Veterans exposed to agent Orange are at increased risk of aggressive recurre...cancerous prostates showed that the 206 exposed to agent Orange had nearly a 50 percent increased risk of t...gy of these cancers that are associated with prior agent Orange exposure that is causing them to be more ag...

A dirty job but ...

...ation with Israeli researcher Dr. Zvi Ludmer, are working on a new cleaning agent that binds to and whisks dangerous materials away from the soil, leaving de...with just soap and water," says Dr. Gozin. "Chemically-speaking, a cleaning agent of this nature is very difficult to develop." With the new technique, once ...

American Chemical Society Weekly PressPac -- April 8, 2009

...8-276-3273 Fax: 518-276-4887 Email: plattm@rpi.edu ARTICLE #2 FOR IMMEDIATE RELEASE Long-awaited new tests for detecting the bioterrorism agent ricin Analytical Chemistry In a development that could help safeguard people against potential acts of terrorism involving ricin, two groups of...

Ancient diatoms lead to new technology for solar energy

...e glass surface, and then the living organic material is removed, leaving behind the tiny skeletons of the diatoms to form a template. A biological agent is then used to precipitate soluble titanium into very tiny "nanoparticles" of titanium dioxide, creating a thin film that acts as the semiconductor f...
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