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Addiction in Biological News

Brain protein central to both Parkinson's, drug addiction identified

Scientists have identified a protein that appears not only to be central to the process that causes Parkinson's disease but could also play a role in muting the high from methamphetamine and other addictive drugs. The action of the protein, known as organic cation transporter 3 or oct3, fills a...

Researchers find link between nicotine addiction and autism

COLUMBUS, Ohio Scientists have identified a relationship between two proteins in the brain that has links to both nicotine addiction and autism. The finding has led to speculation that existing drugs used to curb nicotine addiction might serve as the basis for potential therapies to alleviate the...

Cocaine: How addiction develops

Permanent drug seeking and relapse after renewed drug administration are typical behavioral patterns of addiction. Molecular changes at the connection points in the brain's reward center are directly responsible for this. This finding was published by a research team from the Institute of Mental H...

Large-scale investment catapults CAMH's mental illness and addiction research forward

The Centre for Addiction and Mental Health (CAMH) is proud to announce a landmark investment of $15 million by the Canada Foundation for Innovation (CFI) into research that will propel the understanding, intervention, treatment and prevention of mental illness and addiction to the next level of ex...

'Erasing' drug-associated memories may stop drug addiction relapses

'Erasing' drug-associated memories may prevent recovering drug abusers from relapsing, researchers at the University of Cambridge have discovered. The team, led by Professor Barry Everitt, was able to reduce drug-seeking behaviours in rats by blocking a brain chemical receptor important to learn...

Coral's addiction to 'junk food'

Over two hundred million humans depend for their subsistence on the fact that coral has an addiction to junk food - and orders its partners, the symbiotic algae, to make it. This curious arrangement is one of Natures most delicate and complex partnerships a collaboration now facing grave threa...

Hungry mothers risk addiction in their adult children

Babies conceived during a period of famine are at risk of developing addictions later in life, according to new research published in the international journal Addiction. Researchers from the Dutch mental health care organisation, Bouman GGZ, and Erasmus University Rotterdam studied men and women...

New genetic research into nicotine addiction shows promise for personalized treatment

Whether a smoking-cessation drug will enable you to quit smoking may depend on your genes, according to new genotyping research from the Centre for Addiction and Mental Health (CAMH). The study, published in the September issue of the journal Biological Psychiatry, found that the enzyme known to m...

Drug-proof zebrafish reveal secrets of addiction

The effects of amphetamines on gene expression in zebrafish have been uncovered. This new study, published in BioMed Central's open access journal Genome Biology , provides clues to the genetics that underlie susceptibility to addiction by describing the nad zebrafish mutant, which does not feel ...

Abuse of painkillers can predispose adolescents to lifelong addiction

No child aspires to a lifetime of addiction. But their brains might. In new research to appear online in the journal Neuropsychopharmacology this week, Rockefeller University researchers reveal that adolescent brains exposed to the painkiller Oxycontin can sustain lifelong and permanent changes ...

Cognitive, genetic clues identified in imaging study of alcohol addiction

People with clinical addictions know first-hand the ravages the disease can take on almost every aspect of their lives. So why do they continue addictive behaviors, even after a period of peaceable abstinence" Some answers appear rooted in regions of the brain active during decision making. ...

A link is found between morphine addiction and the tendency to explore

A team of researchers from the UAB has found experimental evidence in rats showing a link between addiction to morphine and the tendency to explore perseveringly. This is the first time a direct relationship has been found without other psychological characteristics, such as anxiousness, that might...

Grabbing addiction by the tail

Canadian scientists have developed some clever molecular trickery that is helping to reduce the drug cravings of addicted rats. One of the problems in addiction is that neurons in some parts of the brain lose glutamate receptors from the cell surface, and those receptors are important for communica...

NIH stimulus funding supports Emory biomedical scientists

...entists expect to advance research discoveries in areas ranging from heart disease, cancer and neurology to organ transplantation, pulmonary diseases, addiction and epilepsy. In addition to research grants, NIH provided funding for Emory scientists to hire eight high school students, 22 college students, a...

Discovery may provide new treatments for alcohol dependence

... Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin's actions in the brain are blocked, alcohol's effects on the reward system are reduced. It is an i...

Cocaine: Perceived as a reward by the brain?

... the reward circuits in the brain but also associates the susceptibility to addiction with these mechanisms. The results of this study show that sniffing coca...reward circuit that leads to addiction, or is it an inherent sensitivity to addiction that leads to the increased secretion of dopamine? This question is not eas...

MCG researcher among first to receive NIH stimulus funding

...ot been clinically identified yet, that would make a difference when deciding a treatment plan," Dr. NeSmith says. Some drugs used to treat cocaine addiction have adverse effects on the kidneys, so it's important to know if a patient suffers from asymptomatic renal disease. If that's the case, alternative d...

Skin color clue to nicotine dependence

... types of smoking behavior, dependence, and health outcomes that will be different from those in less pigmented populations," explained King. "And the addiction process may very well be longer and more severe." The team's findings appear in the June issue of the journal Pharmacology, Biochemistry and Behavi...

Early isolation linked to enhanced response to cocaine

... NEW ORLEANSDrug addiction affects millions of people around the world, causing numerous problems ranging from emotional and psychological difficulties to physical and health is...

Early isolation linked to enhanced response to cocaine

... NEW ORLEANSDrug addiction affects millions of people around the world, causing numerous problems ranging from emotional and psychological difficulties to physical and health is...

To fight drug addiction, UB researchers target the brain with nanoparticles

... BUFFALO, N.Y. -- A precise, new nanotechnology treatment for drug addiction may be on the horizon as the result of research conducted at the University at Buffalo. Scientists in UB's Institute for Lasers, Photonics and Biopho...

Study suggests salt might be 'nature's antidepressant'

...ve substance -- almost like a drug. One sign of addiction is using a substance even when it's known to be ha...ow-sodium foods bland. Another strong aspect of addiction is the development of intense cravings when drugs ...o the same brain pathways as those related to drug addiction and abuse," Johnson said. ...

Addiction: Insights from Parkinson's disease

...ides vital insights into the neurological basis of addiction by investigating Parkinson's disease patients, who...pment and maintenance of addictive behaviours. addiction is a complex health and societal problem that can ...communities. Brain imaging studies have shown that addiction severely alters brain areas critical to decision-m...

Nicotine activates more than just the brain's pleasure pathways

...ngs complement what is known about the effects of nicotine in the dopamine pathway. This is the classic pleasure pathway in the brain, much studied by addiction experts. "Our study in no way contradicts prior findings about nicotine and dopamine," Oliveira-Maia said. "Our findings add to what is known and sugg...

Rethinking the genetic theory of inheritance

... Embargoed Until January 18, 2009 at 18:00 Greenwich Mean Time / 13:00 Eastern Standard Time (TORONTO): Scientists at the Centre for addiction and Mental Health (CAMH) have detected evidence that DNA may not be the only carrier of heritable information; a secondary molecular mechanism called ...

Honeybees succumb to cocaine's allure

...nd out more about the drug's effects. He hopes to identify the neural pathways that it targets to find out more about the mechanisms involved in human addiction and to find out whether the drug has as devastating an effect on honey bee society as it does on human society. ...

NARSAD announces 2008 Prizes for Outstanding Achievement in Research on Mental Health Disorders

...n Institute at the Mount Sinai School of Medicine, in New York. The goal of Dr. Nestler's research is to better understand the molecular mechanisms of addiction and depression. He uses animal models to identify the ways in which drugs of abuse or stress change the brain to lead to addiction- or depression-like...

Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue

...ell studied protein involved in inflammation, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, the effect of general anesthetics and addiction to alcohol, nicotine and cocaine. Moreover, the results apply to closely related receptors that bind serotonin and GABA, which are neurotransmitter...

American Chemical Society's Weekly PressPac -- Sept. 10, 2008

... ARTICLE #1 FOR IMMEDIATE RELEASE Potential new drug for cocaine addiction and overdose Journal of the American Chemical Society Chemists are reporting development of what they term the most powerful substance ever disc...

Unlocking mystery of why dopamine freezes Parkinson's patients

... CHICAGO -- Parkinson's disease and drug addiction are polar opposite diseases, but both depend upon dopamine in the brain. Parkinson's patients don't have enough of it; drug addicts get too much of it...

If your first cigarette gave you a buzz and you now smoke, a gene may be to blame

...otine Research Laboratory. "If cigarette smoking is sustained, nicotine addiction can occur in a few days to a few months," he adds. "The finding of a geneti...together. "Understanding the genetics of complex disorders such as nicotine addiction will require much more research on key traits," he says. The team notes ...

Study finds connections between genetics, brain activity and preference

...ge of behaviors," says Hans Breiter, MD, senior and corresponding author of the study and principal investigator for the Phenotype Genotype Project in addiction and Mood Disorders, an interdisciplinary project involving the MGH Departments of Radiology, Psychiatry, and Neurology. "In the ongoing discussion ab...

Humans' response to risk can be unnecessarily dangerous, finds Tel Aviv University study

... complex the risk, the more difficult to predict how people will react. Lotem cautions that in complicated decision-making scenarios such as gambling, addiction and excitement are new variables that come into play. It is also difficult to assess whether children exhibit similar risk-taking strategies as adults...

Lab study shows methadone breaks resistance in untreatable forms of leukemia

... discovered that methadone, an agent used to break addiction to opioid drugs, has surprising killing power agai...hile methadone can, itself, become addictive, that addiction is much easier to break compared to addiction to true opioids. "Addiction shouldn't be an unsolv...

N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets

...aluable to developing more effective therapies for mood disorders and neurologic and psychiatric diseases, and to direct effective treatments for drug addiction to cocaine and amphetamines," says co-lead author Dr. Harel Weinstein, Chairman and Maxwell M. Upson Professor of Physiology and Biophysics, and direc...

Pregnant mice block out unwelcome admirers to protect their pups

... of hormones. Dopamine is also found in humans, where it is mostly known for its role as the brain's 'reward chemical' that plays crucial roles in addiction and neurological disorders like Parkinson's disease, but it is also found in the human olfactory bulb. It is unknown if a process similar to the pheno...

Hunger hormone: Makes food more attractive

... and colleagues found that ghrelin worked on regions of the brain known to be involved with reward and motivation, the same regions implicated in drug addiction the amygdala, insula, the orbitofrontal cortex (OFC) and striatum. These areas work together to assign incentive value to objects in the world and to...

New gene discovered for new form of intellectual disability

... The Centre for addiction and Mental Health (CAMH) has discovered a new form of intellectual disability involving mental retardation (MR) along with the eye defect retinitis pi...

Epigenetic changes discovered in major psychosis

...ourney to fully understanding major psychosis. Dr. Arturas Petronis, senior scientist in the Krembil Family Epigenetic Laboratory at the Centre for addiction and Mental Health (CAMH), and his team studied 12,000 locations on the genome using an epigenomic profiling technology developed at CAMH. Approximate...

Methadone even at therapeutic levels can kill

...is taken at therapeutic levels primarily for relief of chronic pain or drug addiction withdrawal, a new study by Oregon Health & Science University researchers s... of methadone, a synthetic opiate, is increasing steadily not only for drug addiction but also among cancer patients for managing chronic pain largely because it...
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