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Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering

Sacramento - Today, Affymetrix, Inc.announced plans to make eight new GeneChip(R) plant and animal genomearrays available in 2005 as part of its Consortia Program, includingcanine, Rhesus macaque, Medicago trancatula (legume), Brassica, tomato,citrus, poplar and sugar cane. More than 20 research presentations atthis week's Plant and Animal Genome Conference XIII in San Diego,Calif. feature...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

Foreveryone doing or reading a paper about microarray-based experiments,reproductibility, especially inter-lab, is the #1 concern. Can I trustthese results? If I redo the same experiment in one month, will I beable to compare both? The NIH recently demonstrated that microarrays experiments performed in d...

Breakthrough Microarray-based Technology for the Study of Cancer

A new development in the analysis of cancerhas been announced by Agilent Technologies. The company has reported aninnovative method that enables the rapid advance of microarray-basedcomparative genomic studies in cancer. According to the reportpublished in the December 24, 2004 issue of the Proceedings of theNational Academy of Science (PNAS) in collaboration with the NationalHuman Genome R...

Nanogen Issued Patent for Electronic Microarray With Memory

Nanogen, Inc. (Nasdaq: NGEN), developer of advanced diagnostic products, announced today that it was issued U.S. Patent No. 6,867,048, "Multiplexed Active Biologic Array" by the U.S. Patent and Trademark Office. The '048 patent relates to a method of addressing one or more electrodes (or "test sites") across multiple rows and columns of a microarray. The patent also covers a method for storing th...

An entropy-based gene selection method for cancer classification using microarray data

Accurate diagnosis of cancer subtypes remains a challenging problem. Building classifiers based on gene expression data is a promising approach; yet the selection of non-redundant but relevant genes is difficult. The selected gene set should be small enough to allow diagnosis even in regular clinical laboratories and ideally identify genes involved in cancer-specific regulatory pathways. Here an...

Genrate: a generative model that finds and scores new genes and exons in genomic microarray data

Abstract : Recently, researchers have made some progress in using microarrays to validate predicted exons in genome sequence and find new gene structures. However, current methods rely on separately making threshold-based decisions on intensity of expression, similarity of expression profiles, and arrangements of exons in the genome. We have taken a Bayesian approach and developed GenRate,...

Different microarray systems more alike than previously thought

A multicenter comparison of equipment that can analyze the expression of thousands of genes at once to create a genetic "fingerprint," suggests these different microarray technologies are more alike than once thought. Published in the May 2005 issue of Nature Methods, the study provides new hope that the mounds of information generated by these systems might actually be comparable, even t...

Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays

Agilent Technologies Inc. (NYSE: A) today announced that it has for the first time released the chip design, probe sequence and annotation information for all of its microarrays. The release of this information is expected to improve cross-laboratory experimental research and cross-platform data comparison. "Full release of the probe sequences is an admirable and responsible position for A...

Characterizing Skin Cancer by Microarrays

Microarray technology can be used to identify each stage of skin cancer tumor (melanoma) progression, according to a newly published report. Christopher Haqq and colleagues dissected a large primary melanoma into r...

Microarrays as phenotype

Microarrays provide a method of quantifying the expression and order of genes in a particular genome -- acting as a surrogate measure of cell physiology, said researchers at Baylor College of Medicine in a report that appears online today in the journal Nature Genetics. "Microarray data are good phenotypes to determine the order of genes and are a good surrogate measure of cell status," sa...

Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research

Which is more likely to happen - you being in a car wreck or being bitten by a shark? Those who answered that cars are greater killers win a free trip to the beach. It's really no contest, says a Texas A&M University professor. Your chances of being in a wreck are far greater than being a shark's lunch, says John McEachran, a professor of wildlife and fishery sciences who has studied...

To translate touch, the brain can quickly rearrange its sense of the body

The brain is bombarded by information about the physical proportions of our bodies. The most familiar sensations, such as a puff of wind or the brush of our own shirt sleeve, serve to constantly remind the brain of the body's outer bounds, creating a sense of what is known as proprioception. In a new study, researchers report this week that the brain's ability to interpret external signals and up...

$6.5 Million Grant for Microarray Center at Yale School of Medicine

In 1909, while harvesting a typical corn crop (Zea mays) in Illinois, a field worker noticed a plant so unusual that it was initially believed to be a new species. Its "peculiarly shaped ear" was "laid aside as a curiosity" and the specimen was designated Zea ramosa (from the Latin ramosus, "having many branches"). Due to the alteration of a single gene, later named ramosa1, both the ear and the...

Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research

Tuberculosis remains a major global health threat. Although more than 3 billion doses of the BCG vaccine have been administered to fight tuberculosis, the ability of the BCG vaccine to protect adults is very limited, as is its efficacy against newly emerging isolates. In a study appearing online on August 18 in advance of print publication of the September 1 issue of the Journal of Clinica...

Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible?status

Genomatix Software GmbH today announced that it has achieved GeneChip-compatible GeneChip® microarray platform and that it has joined Affymetrix GeneChip-compatible Applications Program, which provides customers with a broad spectrum of software solutions for biomedical research and development. As a GeneChip-compatible...

Microarray technology for tailoring breast cancer therapy

Microarray technology could be used to tailor therapy according to the individual, and prevent breast cancer patients from having to undergo painful unsuccessful therapies. In a study published in the journal Breast Cancer Research, researchers analysed tumour tissue samples and identified a group of64 genes that can be used to predict a patient's response in the five years after adjuvant therapy...

Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool

A standard Internet protocol that checks errors made during email transmissions has now inspired a revolutionary method to transform DNA microarray analysis, a common technology used to understand gene activation. The new method, which blends experiment and computation, strengthens DNA microarray analysis, according to its Carnegie Mellon University inventor, who is publishing his findings in the...

Nanowire arrays can detect signals along individual neurons

Opening a whole new interface between nanotechnology and neuroscience, scientists at Harvard University have used slender silicon nanowires to detect, stimulate, and inhibit nerve signals along the axons and dendrites of live mammalian neurons. "We d...

Global warming may warrant new approaches to ecosystem restoration

Ecosystems behave in unpredictable ways and, because of this, restoration ecologists are often faced with unforeseen challenges. Researchers, in a recent article published in Restoration Ecology, argue that restoration methods of the past may not always be applicable in the future They see the largest potential challenge ahead is restoring environments undergoing the most rapid rate of change...

Affymetrix 500K array used to identify memory gene

Affymetrix Inc. announced today that researchers at the Translational Genomics Research Institute (TGen) in Phoenix, Arizona have used the Affymetrix 500K Array to discover a gene--called Kibra--associated with memory performance in humans. The team's findings may be used to develop new medicines for memory-based diseases such as Alzheimer's and Parkinson's by providing scientists with a better u...

Chromosomal microarray analysis proves accurate

Two years and more than 2,000 samples after researchers at Baylor College of Medicine started to use a new gene-chip technology called chromosomal microarray analysis to look for potential genetic abnormalities in children, they find that it is remarkably sensitive in detecting abnormalities in individual chromosomes, according to a report that appears online today in the journal Public Library o...

NIH neuroscience microarray consortium launches high-throughput genotyping services

The NIH Neuroscience Microarray Consortium today announced that it has added high-density genotyping on both the Affymetrix and Illumina platforms to its list of services. Stan Nelson, the principal investigator at UCLA, says that "adding ultra-high throughput genotyping for its user-base of ~10,000 investigators across the world keeps the Consortium current with the demands of the scientific com...

Mercury contamination of fish warrants worldwide public warning

The health risks posed by mercury contaminated fish is sufficient to warrant issuing a worldwide general warning to the public ?especially children and women of childbearing age-to be careful about how much and which fish they eat. That is one of the key findings comprising "The Madison Declaration on Mercury Pollution" published today in a special issue of the international science journal Ambi...

Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies

Two researchers from the University Hospital and the Center for Applied Medical Research (CIMA) from the University of Navarra have published an article in , one of the leading scientific journals in the area of cancer studies. The article, written by Ignacio Melero and Sandra Hervas-Stubbs, together with other scientists from the United States and Great Britain, addre...