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Mutation in Biological Dictionary

Mutation

In biology, mutations are changes to the nucleotide sequence of the genetic material of an organism. Mutations can be caused by copying errors in the genetic material during cell division, by exposure to ultraviolet or... mutation n. The act or process of being altered or changed. .....

Silent Mutation

Silent mutations are DNA mutations that do not result in a change to the amino acid sequence of a protein. They may occur in a non-coding region, or they may occur within an exon in a manner that does not alter the final amino acid sequence. The phrase silent mutation is often used in...

Point Mutation

A point mutation , or single base substitution, is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide of the genetic material, DNA or RNA. Often the term point mutation also includes insertions or deletions of a single base pair. One ...

Nonsense Mutation

In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein... In biology, mutations are changes to the nucleotide seq...

Missense Mutation

In genetics, a missense mutation is a point mutation in which a single nucleotide is changed, resulting in a codon that codes for a different amino acid. This can render the resulting protein nonfunctional. Such mutations are responsible for diseases such as Epidermolysis bullosa, sickl...

Homeotic mutation

Homeosis is the transformation of one body part into another, arising from mutation in or misexpression of specific developmentally critical genes. It may be caused by mutations in Hox genes, found in animals, or others such as the MADS-box family in plants. Homeosis is a characteristic that ...

Frameshift Mutation

A frameshift mutation is a genetic mutation caused by indels, ie. insertion or deletion of a number of nucleotides that is not evenly divisible by three from a DNA sequence. Due to the triplet nature of gene expression by codons, the insertion or deletion can disrupt... frames...

Back Mutation

Aspects of the topic back - mutation are discussed in the following places at Britannica. Assorted References genetic mutations ( in heredity (genetics): Gene mutation ; ...against which to compare a mutant allele. Mutation can occur in two directions; mutation from wild type to mutant i...

VNTR

...R typically exhibits a large range of copy numbers, even among highly ... Variable-Number Tandem Repeats ( VNTR's ) are well known for their high mutation ... Some VNTR's , however, exhibit polymorphism in their individual repeat sequences. ... Psychology research, information, analysis and review...

Virion

...pesvirus virion proteins will help in understanding the processes ... If virion density is determined by efficient Gag-Gag interaction, then mutation ... Cell lysate- and virion -associated fractions were incubated with 100 μl of ... What is virion ? Meaning of virion medical term. What does...

UvrA

...rimer which is able to detect DNA ... ... acid sequence homology with the E. coli UvrA protein comprising 940 residues. ... defined by the mutation in DB7 represents a homolog of the E. coli uvrA gene. ... In vivo, UvrA is present as both a monomer and a dimer, the latter complexing ... In...

Triplet repeat expansion

...e triplet repeat expansion is sometimes called a dynamic or unstable mutation ... Disease. 1.2 Expansion of Triplet Repeats ... Lesson 1: Triple...e triplet repeat expansion is sometimes called a dynamic or unstable mutation ... Sureshkumar S. A Genetic Defect Caused by a Triplet Repeat Exp...

Transversion

... by a spontaneous reversion. Because this type of mutation changes the chemical structure dramatically, the ... can be caused by... transversion n. A point mutation in which a purine is replaced by a pyrimidine, ...ary has ecology, physiology, ... transversion A mutation in which a purine is replaced by a ... transve...

Transposition

...rteries, the aorta is connected to the right ... Information about transposition in the free online ... transposition - (genetics) a kind of mutation in which a chromosomal segment is ... Transposition of the great arteries is a congenital (present at birth) heart defect. ... After a tr...

Tetrad

...rence in general relativity ... The tetrad is the four spores of a yeast or Chlamydomonas, that separate after mating. If the two parents have a mutation in two different genes, the tetrad can segregate as the parental ditype (PD), the non-parental ditype... Shop for Tetrad in the Crafts section...

Spermiogenesis

... At the onset of spermiogenesis , transcription and translation become temporally ... Spermiogenesis is impaired in mice bearing a targeted mutation in the protein ... ...

Single-gene disorder

...rder is a disease that is caused by an abnormality in an ... from a small mutation in a single gene to the addition or subtraction of an ... genetic ...ene profiles for more ... Monogenic disorder . A disorder caused by mutation of a single gene . ... See also: single - gene disorder . Polymerase...

Revertant

...For the revertant , the imipenem MIC was 1 μg/ml and the meropenem MIC was 0.25 μ ... A revertant virus (SV Del6K-revQ21L) containing a point mutation in the deleted ... Neither mutant nor revertant viruses are complemented by the coexpression in ... Revertant information including symptoms, ...

Reverse transcription

...t be copied to cDNA by reverse transcription . ... Reverse transcription occurs inside the ordered structure of this core particle ... High mutation rate - reverse transcription is an error-prone process. ... sensitive reverse transcription of any template, leading to high yields of ful...

Retrovirus

... retrovirus infects a cell, it injects its RNA into the cytoplasm of that ... Society for General Microbiology (Download Article on Retrovirus mutation Rates) ... Human retroviruses in the second decade: a personal perspective. ... A The structure of the RNA genome of the mature retrovirus .....

Recessive gene

... Autosomal recessive inheritance means that the gene carrying the mutation is ... A person who has only one recessive gene mutation is said to be a "carrier" for ... What is autosomal recessive inherit...

Quaternary structure

...zed mainly by weak interactions between ... Quaternary Structure is that level of form in which units of tertiary structure ... Identify the mutation in the structure and develop the causal explanation. ... contribute to tertiary structure . and sometimes to quaternary structure ... quat...

Proteins

...cal reactions. ... Proteins are organic compounds that contain nitrogen in addition to carbon, ... Though proteins themselves do not mutate, a mutation in the genetic material of ... G proteins are so called because they function as "molecular switches, ... G proteins were discovered when Al...

Population genetics

...the study of the allele frequency distribution and change under the influence of the four evolutionary processes: natural selection, genetic drift, mutation and gene flow. It also takes account of population subdivision and population structure in... population genetics n. (used with a sing. ...

Pleiotrophy

...a single gene influences multiple phenotypic traits. Consequently, a new mutation in the gene may have an effect on some or all traits simultaneously. Thi...tropy in yeast by measuring the phenotypes ... Pleiotropy occurs when a mutation in a single gene produces effects on more than ... PLEIOTROPY refer...

Pleiotropy

...a single gene influences multiple phenotypic traits. Consequently, a new mutation in the gene may have an effect on some or all traits simultaneously. Thi...tropy in yeast by measuring the phenotypes ... Pleiotropy occurs when a mutation in a single gene produces effects on more than ... PLEIOTROPY refer...

Phagemid

...85 BP. Functions : (cloning cDNA) ... [ 1] Efficiency of phagemid recovery is approximately 20 ... M13KO7 is an M13 derivative which carries the mutation Met40Ile in gII, with the origin of ... M13KO7 is able to replicate in the absence of phagemid DNA. ... A novel phagemid vector, designated ...

Peptide-binding groove

...peptide binding groove , revealed by X-ray crystallography, ... a. Peptide binding groove of class I MHC molecules. ... A conservative mutation in a class I MHC molecule outside the peptide binding groove stimu ... interacts with the TCR, and not with the peptide binding groove...

Penetrance

...l genetics, the penetrance of a disease causing mutation is the proportion of... penetrance n. The fr...gly, the age-dependent penetrance of the G2019S mutation at age 85 ... ... risk is caused by disease lo... new US study suggests the link between a genetic mutation and the iron overload disorder haemochromatosis i...

Mutagenesis

...edia.org /wiki/ Mutagenesis " Categories: mutation ... Sequencing, Mutagenesis & Labeling ....is is a molecular biology technique in which a mutation ... Nobel Lecture on Invention of Site-Directed ...lish ... insertional mutagenesis - (genetics) a mutation caused by the insertion of ... Multi Site Di...

Mutagen

...ent, that can induce or increase the frequency of mutation in an mutagen any agent (physical or environmental) that can induce a genetic mutation or can increase the rate of ... mutagen specifi... is a substance which increases the frequency of mutation in a plant or ... Definition and other addit...

MSH2

...LH1, MSH2 , and MSH6 proteins was performed ... MLH1 and MSH2 Promoter mutation Analysis ... Immunohistochemical analysis of Msh2 and Fhit protein ...... ... carriers of mutations in MSH2 , the absolute lifetime risk for mutation carriers ... and MSH2 , whereas EnVision™/HRP rabbit/mouse (DAKO) incubat...

Mosaicism

... two populations of cells with different genotypes in one individual, who has developed from a single fertilized egg. Mosaicism may result from a mutation during development which is propagated to only a... mosaicism n. A condition in which tissues of genetically different types occur in the same ....

Mitochondrial DNA

...degrading ... Technical article describing recent DNA studies and evolution hypotheses, by Max Ingman. ... Mitochondrial DNA displays high mutation rates. ... DNA -based technologies have enormous forensic implications in the fight against crime. Mitochondrial DNA MtDNA is perfect for old...

Mispairing

... mutation process which occurs during DNA replication. It involves denaturation and...airing . Nature. 1976; 264(5584):369-70 (ISSN: 0028-0836) ... The point mutation in the tRNA(Lys) gene of mitochondrial DNA (mtDNA) from patients with my...

Minisatellite

.... This provides evidence that minisatellite conversion and crossover arise by a ... MS31 (D7S21) is a highly variable minisatellite with a mutation rate to new ... CBF/NF-Y specifically binds to the 43-bp repeat unit of the minisatellite . ... Minisatellite sequences have been shown to serv...

Mendelian inheritance

...et of primary ... The original article was at Mendelian inheritance . ... Mendelian genetic disorders are disorders caused by a single gene mutation that ... The premise in autosomal dominant inheritance is that an individual who carries ... Mendelian inheritance . Alleles: What are they...

Intragenic

...d to generate genetically ... A large diversity of intragenic compensatory mutations was identified from ... Subsequent analyses of intragenic mutation diversity revealed a significant ... Nevertheless, it appears that intragenic recombination alone is insufficient to ... If intragenic reco...

Insertion mutations

... showed that the nucleic ... In an insertion mutation , a piece of DNA is spliced into the sequence of... nucleotide insertions ... In most cases the mutation is the result of insertion of a large segment, ... mutations have been ... or is it insertion mutation ? can anyone confirm this? thank you : ... Insert...

Initiator tRNA

...tudied. ... Formylation of the initiator tRNA is essential for normal growth of Escherichia coli. The initiator tRNA containing the U35A36 mutation (CUA anticodon) initiates from ... ... acceptor stem and in the dihydrouridine (D) stem of the initiator tRNA (tRNAfMet) ... Initiator ...
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