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Tag: "zero" at biology news

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

Two compounds that zero in on cancer cells spreading throughout the body, while ignoring primary tumor cells, could someday give doctors a whole new weapon in the fight against tough-to-treat metastatic disease, according to Weill Medical College of Cornell University resea...

UCSD discovery may help extend life of natural pesticide

...bre-5--the researchers found that there was either zero or dramatically reduced binding of glycolipids to Bt toxin. They concluded that the defective sugar structure of the glycolipid receptor in each of the mutants prevents Bt from binding. Other members of the research team, coauthors Stuart Haslam and...

Key Trigger Of Opioid Withdrawal Symptoms Found

...s aimed at helping addicts kick their habits. To zero in on the machinery underlying withdrawal symptoms, researchers led by Elena Bagley and Macdonald Christie of the Pain Management Research Institute at Royal North Shore Hospital (a division of the University of Sydney) performed biochemical studies ...

International HapMap consortium expands mapping effort

...searchers will be able to use its SNP signposts to zero in on that particular genomic region and search for specific genes involved in that disorder. This approach can reduce the work and expense of searching the genome for hereditary factors in common disease by a factor of 20 to 40 compared with current...

Genetic defects give the immune system the green light to attack the pancreas

...found the chromosomal regions involved and can now zero in on the precise genes,?said Diane Mathis, Ph.D., the study’s principal investigator along with Christophe Benoist, M.D., Ph.D. They head the Section on Immunology and Immunogenetics at Joslin, and hold joint William T. Young Chairs in Diabetes Rese...

Road salt affects mitigation wetlands

...and in the other affected wetland." Freshwater has zero salinity, while seawater has a salinity of about 2... stress. "Last year all the wetlands went back to zero salinity in mid spring," says Silver. "We are not sure if this will continue as we do not know if th...

NHGRI targets 12 more organisms for genome sequencing

...of laboratory rats. SNPs can be used as markers to zero in on genetic variations that may affect an individual's risk of developing common, complex illnesses such as heart diseases, diabetes and cancer. Building a catalog of rat SNPs will assist researchers trying to find genetic variations associated wit...

New understanding of cell movement may yield ways to brake cancer's spread

... to the proper places to form organs, immune cells zero in to destroy pathogenic organisms, and cancer cells metastasize, spreading deadly disease through the body. Scientists studying these migrations didn't know how cells determined where to go. Until now. A Burnham Institute study has identified a fra...

Energy management in cells may hold key to cancer defense

...said Witters. As Witters' laboratory continues to zero in on the central role of kinases in the treatment of disease, he acknowledges that this research is becoming more complex and multiple approaches are needed to find solutions. Witters believes that significant breakthroughs in science can only be a...

UW-Madison scientists zero in on drugs' sweet spots

...lex chemistry that underpins them. The ability to zero in on the sweet spot of drugs derived from natural products promises to help scientists specify the role of the sugar and make new drugs or enhance old ones to greater precision and effect. The series of experiments performed by Thorson's team, for e...

Continued reduction in the number of drug-related deaths in the UK

...in 2004; South Northumberland saw an increase from zero to 5; the number of deaths in Central & South East Kent rose from 2 in 2003 to 7 in 2004; and in North Tyneside there were 4 deaths in 2004, compared to none in 2003. In commenting on the above data, Professor Hamid Ghodse, Director of the Inter...

Complex gene interactions account for autism risk

...lied sophisticated statistical methods designed to zero in on the effects of particular gene combinations. The researchers found that one of the GABA receptor genes, GABRA4, is involved in the origin of autism. Moreover, they report, GABRA4 appears to increase autism risk through its interaction with a s...

NIAID researchers show how promising TB drug works

...of work; this new technology enables scientists to zero in on the specific genetic difference between mutant and normal bacterial strains in just days, says Dr. Barry. The scientists found a total of four PA-824-resistant mutant strains: two lacked the newly described M. tb protein altogether, while the ...

Cord blood cells may widen treatment window for stroke

...esearchers suggest, many nerve cells within ground zero of the attack, like those in mild to moderately damaged outlying areas, may succumb over several days through a slower, more orderly process known as apoptosis, or programmed cell death. "This delayed death would permit more time to deliver neuron-...

Recreating 'Flowers for Algernon' with a happy ending

...LA team began searching for a safe drug that would zero in on Ras and overcome its hyperactivity without causing harmful side effects over long-term use. "It became something of a Quixotic quest -- an impossible dream," Silva admitted. "We thought, 'Wouldn't it be nice to find a drug that is already FDA...

Microbes under Greenland Ice may be preview of what scientists find under Mars' surface

...eral hundred meters, where the temperature - about zero degrees Celsius (32 degrees Fahrenheit) or a bit warmer - would allow just enough metabolism for them to keep alive, just as the microbes in the Greenland ice sheet are doing. ...

Embryos tell story of Earth's earliest animals

...n a few million years, the fossil record goes from zero evidence of animals to great diversity in animal forms, including anomalocarids and trilobites. Harvard University biologist and historian Stephen Jay Gould brought this "Cambrian explosion" to the popular consciousness in 1990 with his book Wonderfu...

Ocean virus identified in human blood samples

... antibody prevalence in various herds ranging from zero to 80 percent. It concluded that Vesivirus infection in cattle is widespread, and in various studies has been "associated" ?identified to be statistically relevant but not yet proven as a cause - with abortion, diarrhea, severe respiratory disease an...

Scientists reveal how deadly toxin hijacks cells

...own as "entry assays," the scientists were able to zero in on SV2. To confirm that result, they acquired mice that were genetically engineered to carry reduced amounts of SV2. Without that protein around, the researchers found that botox was unable to wreak havoc. Co-author Felix Yeh, a UW-Madison gradua...

Paleontologists learn how not to become a fossil

...ciences. "This gives us some strategies for how to zero in on the most reliable data," she said. The PNAS co-authors focused on bivalves (clams, scallops, oysters, cockles and their kin), because they serve paleontologists the way geneticists use mice or fruit flies as model systems. Jablonski called the...

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