High fidelity keeps human DNA assembly line humming
...ofessor of biochemistry and molecular biology. "If you want to understand and control things like viral infections and tumors this fundamental process has to be understood in every detail. This is basic science, but basic science with practical application." Burton and his team study how RNA is made fro...Researchers reveal secret of key protein in brain and heart function
... neurological diseases. "To arrive at a solution, you need to understand the problem," Mierke said. "Solving protein structures opens doors for effective treatments." SAP97 is found mainly in the central nervous system and is known as a "scaffolding" protein. In this role, it serves as a sort of tether...Study of energy and health in Africa focuses spotlight on charcoal and forest management
...roleum-based fossil fuels an unlikely option. "If you switch everyone off the dirtiest fuels to burning clean fossil fuels, you get the biggest health benefit," acknowledged Daniel Kammen, the Class of 1935 Distinguished Chair o...Random gene expression may drive HIV into hiding
...ndergo before it allows more HIV to be made. "When you quantify things and dissect them at this level, it gives you ways of exploring where your most vulnerable places might be." Commenting on the work in a preview ...Scientists discover global pattern of big fish diversity in open oceans
...ed by up to 50% in the last 50 years. "Everywhere you go, in every ocean basin, our "hotspots" today are... local fishing out of species," says Myers. "Where you once had a range of a species in dense numbers, now you might catch one or two of a certain species....MIT engineers an anti-cancer smart bomb
...blem. "You can't deliver chemotherapy to tumors if you have destroyed the vessels that take it there," Sasisekharan said. Also, the two drugs behave differently and are delivered on different schedules: anti-angiogenics over a prolonged period and chemotherapy in cycles. "We designed the nanocell keepin...Ocean climate predicts elk population in Canadian Rockies
...e statistics from the north Pacific Ocean and tell you how the elk are doing in Banff National Park. The University of Alberta doctoral student is the first researcher to show a correlation between the North Pacific Oscillation (NPO) and a mammal population. Based on many climate-related ocean measureme...Program finds lost genes in nematode genome
...nome," Brent said. "It's quite a step up from what you see in the human genome, for instance, where not e...ore expensive, but because of the lower redundancy you end up with much better coverage of the genome for the same money." Chess as metaphor Brent said t...Revueltosaurus skeleton unearthed at Petrified Forest upsets dinosaur tale
...ntology at UC Berkeley. "We think we've shown that you can't rely on the dentition to determine what is a... dinosaur evolution radically shifts. "Basically, you have two groups that were thought to appear at the same time and co-evolve, and now you have one com...Two studies document rise of superbugs in the environment
... MRSA infections mainly involves common sense. "If you get a cut or an abrasion, try to keep it clean and dry" and don't share towels or washcloths with others, Dr. Kaplan said. Most importantly, he added, "Wash hands, wash hands, wash hands." And if regular drug-resistant bacteria weren't bad enough, s...Agilent Technologies introduces high-capacity human protein removal system for proteomics research
...ntology at UC Berkeley. "We think we've shown that you can't rely on the dentition to determine what is a... dinosaur evolution radically shifts. "Basically, you have two groups that were thought to appear at the same time and co-evolve, and now you have one com...Certain fish have a special mating preference
...en as just another morphological character, and if you think of them that way, females might be choosing just as they would for any morphological trait," he said. "This at least partially explains the variability in male genital morphology." Using this study as a springboard, Langerhans is exploring the...IMF Launches World’s First DNA Database for Myeloma Patients
...en as just another morphological character, and if you think of them that way, females might be choosing just as they would for any morphological trait," he said. "This at least partially explains the variability in male genital morphology." Using this study as a springboard, Langerhans is exploring the...Mosaic mouse technique offers a powerful new tool to study diseases and genetics
... the Howard Hughes Medical Institute. "With MADM, you can look at a tiny subset of cells and study gene ...a green fluorescent protein," Luo says. "So now if you mutate a gene, you'll know in which cell the normal gene is lost. For example, if you delete a tumor...Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
...ies plays in the biofilm community. "Genomes tell you about the genetic potential of organisms that are ...ist at Lawrence Berkeley National Laboratory. "But you can't tell whether they are doing it or not. We want to go beyond the level of 'Can they?' to 'Are t...By creating molecular bridge, scientists change function of a protein
...of these intermediate functions. If done, it gives you the ability to create protein functions for any purpose you want -- as a catalyst to create new chemicals that might be useful in such things as therapeutics, f...Where Bacteria Get Their Genes
...bacteria is crucial for medicine, Ochman said. "If you go to the doctor with strep throat he can be prett... therefore prescribe an appropriate antibiotic. If you couldn't classify bacteria because they have genes from all over, doctors wouldn't be able to do thi...Bioinformatics reveals new gene regulation system
...of bioinformatics. "It's a proof of principle that you can go a very long way by comparative genomics now...it the same 'neighborhood' of the chromosome. "If you are looking in one genome, many genes will be neighbors by coincidence," Gelfand noted. "But if two ...One hit of crystal meth causes birth defects
...mice, which surprised me," says Wells. "In adults, you can see actual structural degeneration of the brain." U of T doctoral candidates Winnie Jeng and Andrea Wong and undergraduate Ryan Ting-A-Kee were also involved in this study. The research was supported by a grant from the Canadian Institutes of He...Researchers find first evidence of venom system in extinct mammal
...ly rare for a specimen this old. "This just shows you that no matter how long you've been working on something, you can still learn a lot just by uncovering one little piece of information," Fox added. "And we're for...