Eliminate Data Analysis Bottlenecks in Drug Discovery
...erent proteins, and it's just this one interaction you would want to prevent." But, he says, PGC1 has an unusually close relationship with sirtuin1 that may make for relatively easy picking. PGC1, unlike the vast majority of proteins, only uses sirtuin1 to remove its "decorations," called acetyl groups....Researchers find gene that may be at root of potato blight
... Research and Development Center in Wooster . "If you take a gun through the metal detector at an airport, the alarms go off," he said. "This gene (Avr3a) sends a signal alerting the plant that it is infected by the pathogen." Phytophthora infestans is the pathogen that causes late blight. For decades,...Where bacteria get their genes
...bacteria is crucial for medicine, Ochman said. "If you go to the doctor with strep throat he can be prett... therefore prescribe an appropriate antibiotic. If you couldn't classify bacteria because they have genes from all over, doctors wouldn't be able to do thi...Young Blood Revives Aging Muscles, Stanford Researchers Find
...o small task. "It's as big a fishing expedition as you can possibly imagine," he said. With thousands of proteins, lipids, sugars and other small molecules in the blood serum, deciding where to look first would be tantamount to a roll of the dice. What's more, there's no evidence that the same blood comp...Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips
...till are unknown," Kao said. "There's no knowledge you can gain from these overproducers to turn around and make others." That's where Kao comes in. On Sunday, she will present her latest progress at the 229th annual meeting of the American Chemical Society in San Diego, focusing on research that earned...'EuroVacc 02' HIV Vaccine Trial Begins
...ion; be sure to read the 'note' part at the end if you want to understand what the vaccine is about. Lausanne, Switzerland and London, United Kingdom, February 16, 2005 -- The European Vaccine Effort against HIV/AIDS today announced that a phase I clinical trial of novel investigational vaccines compri...Pair of cancer genes found to drive both cell migration and division
...nd in over half of all human cancers. "In cancer, you sometimes see cells failing to divide or undergoin... cell," says Devreotes. "But we've found that when you look at the whole cell, there are a lot of similarities between division and movement." In normal c...Scientists use manufacturing methods to reconstruct mastodon
... very accessible; it's not something esoteric that you need a Ph.D. to understand," said museum director Amy Harris. "The expanded exhibit offers us an opportunity to feature his research in interesting and engaging ways." In addition to being an impressive addition to the museum's exhibit space, the Bu...Atmosphere may cleanse itself better than previously thought
...rn," he said. "Sometimes things are happening that you can't see using standard methods. Now we hope to take this improved understanding of the atmosphere and include it in future models ?that’s the next step." This research was supported in part by the National Science Foundation. ...Researchers pioneer new gene therapy technique using natural repair process
.... "SCID is ideal for this sort of therapy because you only need to correct the defect in a small number of immune cells to fix the problem," said Dr. Porteus, assistant professor of pediatrics and biochemistry at UT Southwestern. "This is called selective advantage; the healthy cells grow and divide pre...Experiment station researchers to explore genome of disease-fighting fungus
... combat the pathogens that remain in the soil when you incorporate low till. In theory, it would be cost-...t plant varieties. "In the nursery industry where you transplant from smaller to larger containers, you can incorporate the fungus as a potting mix amendm...15 generations of untrained jocks, couch potatoes show big physiological adaptations
So, you don't like to exercise? Maybe you could blame it on your great-great-grandparents. Similarly, if you're a practiced and proud couch po...Second messenger NAADP shows fast, dose-related impact on satiety cycle
...are released and the more quickly your brain tells you that you're full ?or at least satisfied. Indeed, it also could be a potential drug for the treatment of obesity, Yamasaki noted. "We have shown that cholecystokinin activates NAADP production through a specific protein on the cell surface, the chole...Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
If you thought the sleep-deprived months with your newborn were tough, pity the poor mother dolphin or killer whale. Reporting in the June 30 edition of the peer-reviewed journal Nature, UCLA/Veterans Affairs neuroscientists report a developmental pattern ...Shark attack worries? Driving to the beach is more deadly
Which is more likely to happen - you being in a car wreck or being bitten by a shark? ...ear-old girl - shark attacks remain very rare when you put it all into perspective, McEachran believes. "There are millions of people in the water at any ...New HIV drug candidate developed in Sweden
Which is more likely to happen - you being in a car wreck or being bitten by a shark? ...ear-old girl - shark attacks remain very rare when you put it all into perspective, McEachran believes. "There are millions of people in the water at any ...Which is more likely to happen - you being in a car wreck or being bitten by a shark? ...ear-old girl - shark attacks remain very rare when you put it all into perspective, McEachran believes. "There are millions of people in the water at any ...Alien woodwasp, threat to US pine trees, found in N.Y.
...enior extension associate in entomology. "Whenever you find an insect in a trap, it probably is established." Hoebeke was sifting through thousands of bark beetles caught in routine screening traps set by the New York State Cooperative Agricultural Pest Survey (CAPS) program, in search of any of 10 exot...Mice brains shrink during winter, impairing some learning and memory
...and learning performance. "We predicted that when you reduce the size of the hippocampus, it would have an impact on learning, and that's what we found," Nelson said. The shrinking of the brain corresponds to a season when the mice may have less need for spatial memory, Nelson said. "They don't mainta...Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
...g that the field has more grass in it--not because you made the grass grow better, but because you killed everything that eats grass," he said. Previous research had found that the lethal ingredient...