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Tag: "yeast" at biology news

New RNA polymerase discovered in plants

...ase for decades in organisms ranging from brewer's yeast to humans. In all eukaryotes, the RNA polymerases Pol I, II, and III perform the same distinct , though separate, functions in different species. But then along came Pol IV. Pikaard first noticed the evidence for a fourth polymerase when analyzing g...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...ne the way genes are packaged in yeast. To go from yeast to humans required a technological breakthrough, however. "Most prior studies involved only single genes, but we wanted to investigate entire chromosomes, which contain hundreds of genes," Bernstein notes. He and Schreiber enlisted the help of Affy...

An HIV Protein Plays a Surprising Role in Gene Activation

...erase's transcribing capacity. Previous studies in yeast had shown that activators appear to stimulate tran...r called E1a—the authors show that what's true for yeast also holds for mammals, or at least for the human cell lines investigated here. Each effector was re...

Novel Enzyme Shows Potential As An Anti-HIV Target

...HR73, a derivative of a molecule that inhibits the yeast version of the SIRT1 protein, caused a 5-fold reduction in HIV transcription. The authors propose a cycle of transcriptional transactivation in which SIRT1 deacetylates Tat at the HIV promoter. Deacetylated Tat associates with CyclinT1 and TAR, and ...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...ains, spinach, seeds andother foods.Their study in yeast cells demonstrated that iron-starved cellspreserve... aneven greater degree. His study was conducted in yeast cells becausetheir genome is remarkably similar to that of a human cell. In fact,the Cth2 protein in...

Timing is everything: First step in protein building revealed

...inue reading the assemblyinstructions. Even though yeast are the most primitive relatives ofhumans, the protein-building machinery, or ribosomes, of each are quitesimilar. "Theidea is to really know at the molecular level how life is puttogether," says Jon Lorsch, Ph.D., professor of biophysics andbiophys...

Man and mouse share genome structures

...es several years earlier, working with the smaller yeast genome. To investigate the much larger human genome, they collaborated with Affymetrix. They isolated the DNA regions with certain major methyl and acetyl tags, and used new microarray technology to identify the underlying genetic sequences associate...

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