New lifespan extension genes found
New genes tied to lifespan extension in yeast have been identified by researchers from UC Davis ...xtension due to caloric restriction, but worms and yeast that lack Sir2 also live longer when put on a tough diet, showing that some other genes must be at w...UCR chemist part of team identifying new areas of gene regulation
... part of a team that has discovered a new way that yeast governs genetic expression and repression, a findi...ntify a novel acetylation site at the lysine 56 of yeast histone H3," said Zhang, referring to the previously unknown location of a chemical opening to allow...Improved statistical tools reveal many linked loci
...lements that produce specific traits. In brewer's yeast alone, Storey and colleagues found that 37% of gen...n two genomic locations control about one in seven yeast expression traits¡Xwhich Storey et al. discovered using their method. Although the group studied ye...Natural tumor suppressor in body discovered by UCSD medical researchers
...mical signaling proteins in organisms ranging from yeast to humans. Once they found PHLPP, which they discovered was expressed throughout the body, the scientists used biochemical and cellular studies in human and other mammalian tissue to determine that PHLPP levels are markedly reduced in several colon ...NHGRI targets 12 more organisms for genome sequencing
...ea squirts, two roundworms, several fungi, baker's yeast and many prokaryotes (bacteria and archaea) including Escherichia coli. Additional organisms already in the NHGRI sequencing pipeline are: the macaque, the orangutan, the kangaroo, the cow, the gray short-tailed opossum, the platypus, the red flour b...15-year hunt finds cause of pseudothalidomide syndrome
... the syndrome. Knocking out the equivalent gene in yeast and fruit flies led to the same chromosome problems, says Gordillo. "Comparative genomics didn't really exist even five years ago," says Jabs. "Techniques to genetically engineer yeast, fruit flies and even mice have dramatically improved in the las...To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
... to identify the genes in Saccharomyces cerevisiae yeast and human cells that induce mutations that can transform normal cells into cancer cells. The article, "Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance" by Ryan T. Cirz, Jodie K. Chin, David R. Andes, Valöée de Crï'-Lagard...Study reveals candidate targets for anti-retroviral therapeutics
... these mobile elements (called Ty ?or transposable yeast ?elements) encode proteins that are homologs of re... by Ty elements and the steps of the life cycle in yeast are similar to the proteins encoded by retroviruses and their life cycles in animal cells. Scientist...Insight into DNA's 'weakest links' may yield clues to cancer biology
...cists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begi...in the March 11, 2005, issue of Cell, suggest that yeast may offer a useful model system for studying the fundamental properties of so-called DNA fragile sit...New tumor-suppressor gene discovered
...find a counterpart to the mats gene in yeast. This yeast counterpart is known to make a protein that forms a complex with a kinase--an enzyme that catalyzes genetic activity--so we wondered if the protein product of our mats gene also could function in this way." Lai was particularly intrigued by the possi...Yeast Network Prevents Damage By Oxygen Radicals
...work of DNA repair and cell cycle control genes in yeast that prevents the deleterious effects of ROS. "DN... and lead author, Meng-Er Huang, generated various yeast strains each with a mutation in the TSA1 gene, which results in increased production of ROS, plus a ...Discovery may lead to better Candidiasis drug
...the same way. And we wanted to know why it acts on yeast (fungus is a type of yeast) and not on other types of cells." Through a series of studies, the researchers identified the target-binding protein on Candida albicans by creating mutant strains of the fungus without the target and exposing the mutants...Navigating an integrated yeast network
...pped multiple complex biological interactions in a yeast cell in a simple graphical form, enhancing our und...ent types of biological relationships found in the yeast Saccharomyces cerevisae: protein-protein interactions, genetic interactions, transcriptional regulat...U-M team recovers ancient whale in Egyptian desert
...d subsequently re-animate ?such model organisms as yeast and worms, as well as the embryos of fruit flies and zebrafish. In each case they achieved metabolic suspension through oxygen deprivation caused by exposure to gases such as hydrogen sulfide and carbon monoxide. Known as oxygen mimetics, these chem...Buying Time Through Hibernation on Demand
...d subsequently re-animate ?such model organisms as yeast and worms, as well as the embryos of fruit flies and zebrafish. In each case they achieved metabolic suspension through oxygen deprivation caused by exposure to gases such as hydrogen sulfide and carbon monoxide. Known as oxygen mimetics, these chem...Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
...y "strains" of disease prions across mammalian and yeast species. Researchers thought these strains could b...s the determining factor in whether one species of yeast could infect another yeast species. Just as in the case with the preseeded mice fibrils, a particul...Researchers discover chemical compounds that affect plant growth
... product of bacterial metabolism thought to target yeast cell membranes. With chemical genomics, the team could identify valuable genetic characteristics beyond the reach of conventional mutations, which are often lethal when present in essential genes such as those that encode many cellular membrane compo...50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel
...nown as background (or leak) potassium channels in yeast cells in 1995 and in fruit flies in 1996. Although potassium leak was first described in the 1950s when it was recognized to control excitation of nerves, the reason for leak had not previously been understood. The first human clone of this channel,...Molecular models advance the fight against malaria
...de. The scientists developed disease models using yeast and successfully introduced five mutations that ma...ues continued their work on previous studies using yeast enzymes to explore atovaquone resistance. It is not possible to grow enough malaria parasites to iso...Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits
...tistical comparative analysis of a total of 14,145 yeast (Saccharomyces cerevisiae), worm (Caenorhabditis e...ed fashion. In contrast, the team did not find in yeast a network they found in both worm and fly that is involved in the guidance of nerve cell axons to th...