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Tag: "yeast" at biology news

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

...that we have these genes expressed in a convenient yeast system, we can work to understand the molecular ba...rm − into one that could be "read" by yeast. The yeast are then able to produce the PfMDR1 protein, in its proper sequence, from this synthetic gene. They ...

'Insulator' helps silence genes in dormant herpes virus

...studied regions where insulators are found in both yeast and chicken, namely the yeast mating loci and chicken globin locus. To see if insulators play a role in silencing viral genes d...

Scientists identify prion's infectious secret

...ies to another. Now, through studying non-toxic yeast prions, scientists at Whitehead Institute have dis...ssier covered the array with peptides from baker’s yeast and then added prion protein to the array, also from the same yeast species. He found that a small c...

Latent memory of cells comes to life

...on-existent capacities suddenly to appear. Special yeast cells for example, can abruptly change from being ...experiment molecular biologists used a mutant of a yeast cell which was bi-stable, in that it could become either of a single sex or hermaphrodite. The exper...

Hives ferment a yeasty brew, attract beetle pest

... The beetles are also aided in their invasion by a yeast that naturally occurs on pollen and produces, as a...researchers report. Complicating the issue is the yeast that grows in the hives. The researchers found that this yeast only produced IPA when it grew on pol...

Super-fermenting fungus genome sequenced

...to increase ethanol production.?Jeffries said that yeast strains like Pichia have evolved to cope with the oxygen-limited environment rich in partially digested wood that is encountered in the gut of insects, from where the sequenced strain was originally isolated. FPL has a Cooperative Research and Dev...

Need oxygen? Cells know how to spend and save

...f COX4-1. "It's remarkable that the one-celled yeast also swap COX subunits in response to hypoxia, but because they lack HIF-1, they accomplish the swap in a completely different way," says Semenza. "This suggests that adapting mitochondria to changes in oxygen levels may be a major challenge for most...

A new study of living cells could revolutionize the way we test drugs

...y of the technique, and the normal activity of the yeast cell could not be detected. This is the first time... out the experiments. It worked. As soon as the yeast got a taste of the vodka, the probe registered an electrical signal. A drunken hiccup perhaps? "It w...

Technology reveals 'lock and key' proteins behind diseases

...wo proteins interact in iMYTH, they will stain the yeast cell blue. "Like lock and key, if two proteins int...ably communicate with the ABC transporter Ycf1p, a yeast version of the human proteins CFTR and MRP. These newly discovered protein interactors represent nov...

Scripps research study reveals structural dynamics of single prion molecules

...es." Interestingly, the new study revealed that yeast prion protein Sup35 lacks a specific, static struc...t aggregates. Deniz said that future work with yeast prion mutants might resolve some of the questions that remain unanswered. "Our laboratory has spent ...

DNA ends: Common tool, different job

... in on the short single-stranded DNA "tail" end of yeast chromosomes. Their findings, reported in the onli...n certain cells, such as our germ cells or baker's yeast cells, which need to divide indefinitely, an enzyme called telomerase elongates telomeres to compens...

Stopping plants from getting sick

...search as a foundation to fight an outbreak of the yeast fungus Cryptococcus on Vancouver Island, applying ...is research on plants to help investigate how this yeast causes pneumonia, meningitis and other illnesses in humans and animals. Still, he says he expects to...

Primitive yeast yields secrets of human cholesterol and drug metabolism

By first probing the way primitive yeast make cholesterol, a team of scientists has discove...ns and other animals. Happily, Espenshade says, yeast have only two P450 enzymes, and both play roles in making cholesterol, narrowing down the territory ...

Microfluidic chip helps solve cellular mating puzzle

...g-standing mystery related to the mating habits of yeast cells. The findings, described in the Feb. 18 A...died for many years -- because what we find out in yeast often holds true for humans as well. In this study, we looked at how yeast cells signal one another ...

Brown team finds crucial protein role in deadly prion spread

...eas, Serio and members of her lab studied Sup35, a yeast protein similar to the human prion protein PrP. They put Sup35 together with Hsp104, then activated and deactivated Hsp104. They found that the protein does, indeed, chop up Sup35 complexes ?the first direct evidence that this process occurs in a liv...

Scientists reveal structure of gateways to gene control

...hese promoter nucleosomes are the only ones in the yeast DNA that contain in their core a histone protein c...the identical sequence on the previously published yeast genome. "Obtaining the exact DNA sequences for all these nucleosomes allows us to precisely map the...

Virginia Tech's System X supercomputer provides super tool for simulation of cell division

... interactions regulating the cell cycle of budding yeast (the yeast cells familiar to bakers and brewers, and a favorite organism of molecular biologists, as well). "Su...

Molecular motors and brakes work together in cells

...ell study, the investigators, working with fission yeast cells, showed that stable end-to-end arrays of microtubules can be achieved by a balance between the sliding by a molecular motor called klp2p and the braking of a microtubule-associated protein (MAP) called ase1p. Specifically, they showed that a pr...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...and reported in Nature. The 2003 study showed that yeast treated with resveratrol lived 60 percent longer. ...te Sir2, an enzyme linked to lifespan extension in yeast and other lower organisms. For the last 70 years, scientists have been able to increase the lifespa...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

...t serve as templates for protein in organisms from yeast to humans. Now, Kornberg and his colleagues report in the December 1, 2006 issue of the journal Cell, published by Cell Press, new structures that reveal another critical piece of the puzzle: how the so-called polymerase II enzyme discriminates among...

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