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Tag: "wound" at biology news

A new plant-bacterial symbiotic mechanism promising for crop applications

...It took advantage of “crack zones” comparable with wound areas. The set of results obtained from subsequent work, seeking to identify the genes involved in producing the unknown signal molecule that plays the role of Nod factor, prompted the team’s hypothesis that a molecule similar to a plant hormone (4),...

Genome of Clostridium botulinum reveals the background to world's deadliest toxin

...food or open wounds, leading to infant botulism or wound botulism, both of which are serious human infections. The host can be quickly overpowered and, in some cases, killed by the toxin, and C. botulinum has a new food source. "Although in the same group as Clostridium difficile — the Cdiff superbug —...

Targeting sugar on blood vessels may inhibit cancer growth

...helial growth, such as the reproductive system and wound healing, remained robust." Studying mouse models with a genetic alteration in an important sugar-modifying enzyme (Ndst1), the researchers saw a marked decrease in the growth of experimental carcinomas. The Ndst1 enzyme is responsible for modifyi...

First demonstration of new hair follicle generation in an animal model

...nd hair disorders, and wounds. “We showed that wound healing triggered an embryonic state in the skin w...enerate.) In this study, researchers found that wound healing in a mouse model created an “embryonic window?of opportunity. Dormant embryonic molecular pa...

Exploring the molecular origin of blood clot flexibility

...ots maintain that precise balance of stiffness for wound healing and flexibility to go with the flow? Resea...rchers about clot physiology in such conditions as wound healing, stroke, and cardiovascular disease. Clots are a three-dimensional network of fibers, made ...

Natural polyester makes new sutures stronger, safer

...naturally, so they can be safely absorbed once the wound is healed. They are also 30 percent stronger than sutures now used and very flexible, making them easier for surgeons to work with. The sutures were developed by Tepha, Inc., a Cambridge company that hopes to use the same material to produce an ar...

Cancer cells forming blood vessels send their copper to the edge

...iogenesis ?is important in growth, development and wound healing. But it also enables the spread of tumors throughout the body, so researchers have been scrambling for ways to stop angiogenesis in the fight against cancer. One element critical to blood vessel growth is copper, a vital nutrient that play...

MIT bioengineer advances survival, promise of adult stem cells

...sly difficult to develop as a clinical product for wound healing. To control this, the researchers decided to tether EGF to a scaffold, preventing the stem cells from eating it up and allowing continuous EGF exposure on the cell surface. "Putting them on a scaffold is appealing because then you can c...

How fish mend a broken heart

...ial cells then alters their identity, invading the wound and providing essential new blood vessels to the growing muscle. They further found that the two-part regeneration process is coordinated by so-called "fibroblast growth factor" (Fgf) signals. Fgf signals are known for their ability to encourage in...

Key to zebrafish heart regeneration uncovered

...lay between a mass of stem cells that forms in the wound and the protective cell layer that covers the wound spurs the regeneration of functional new heart tissue, Duke University Medical Center scientists hav...

The effects of smoking on fractures and ligament injuries

...s and smoking has been shown to impair soft tissue wound healing. Two new studies, funded by the National I...reased between 3 and 7 days after injury in normal wound healing, and that this was partially inhibited in mice exposed to cigarette smoke. Based on their fi...

Newts which regrow their hearts

...hat the heart regeneration does not create typical wound healing tissue, called a blastema. Braun explains ...e de-differentiation comes from the area where the wound is healing and the cells communicate with each other," explains Braun. These signals could be transm...

Genome archaeology illuminates the genetic engineering debate

...s have disappeared completely. Corresponding genes wound up in completely different locations within the genome and have likely undergone changes in how they affect biological operations. "The research, conducted by an international collaboration of scientists, will help scientists and farmers improve th...

Hopkins researchers discover how brain protein might control memory

...e two proteins, cells were unable to "swallow" and wound up with more receptors than normal on their surfaces. Adding more Arc to cells caused the opposite to happen; the cells hyperactively swallowed up too many receptors, leaving few at the surface. Unfortunately, it's possible to over-excite a cell ...

MIT material stops bleeding in seconds

... a nanoscale protective barrier gel that seals the wound and halts bleeding. Once the injury heals, the non...earby cells. Even after excess gel is removed, the wound remains sealed. The gel eventually breaks down into amino acids, the building blocks for proteins, w...

From managing sugar to managing healing

... faster"surface cells in the epidermis covered the wound more quickly and cells in the dermis, the deeper p...ls, the insulin stimulates only migration into the wound tissue. The insulin works by switching on cellular signaling proteins called kinases (specifically S...

Beyond the book: Software automates access to brain atlases

... guidance of Swanson and Thompson guidance. Cheng wound up rebuilding NeuART from the ground up, said Burns. The revised NeuARt II interface indexes the data in a variety of ways, including spatial maps and alphanumeric information, coming off a single interface. It includes all the information in the...

UCSD researchers discover internal compass of immune cell

...utrophils to migrate to infected wounds to improve wound healing. ...

Two-faced protein can stop metastasis or promote it, researchers say

...s. Sometimes, such as during human development or wound repair, epithelial cells need to travel to other areas, and to do this, they undergo a process known as "epithelial-mesenchymal transition" (EMT). The cell reduces its production of E-cadherin proteins and increases expression of mesenchymal cadherin...

Researchers find docking sites for glucocorticoid receptor and Hsp90

...porosis, cataracts, ulcers, hypertension, impaired wound healing, diabetes and depression. Thus narrowing the point of attack, such as by manipulating Hsp90-glucocorticoid receptor interaction, is of growing importance, Darimont said. The PNAS paper and a second publication that is under review cover t...

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