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Tag: "works" at biology news

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...tein that the gene codes for. The gene TEL1, which works to slow cell growth and multiplication, is another member of the ETS family and is a known target of mutations in human leukemia. Grosveld's group previously identified TEL2 and noted its similarity to TEL1, which prompted them to investigate whether...

Gene therapy for Parkinson's disease moves forward in animals

...t models, but it's encouraging to see data that it works in higher animals like monkeys." Meanwhile, in se...y the treatment can backfire. "Levodopa generally works great for several years, but then it actually starts creating movement problems," Mandel said. "Our ...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...acteria, LPS helps to reveal how the immune system works on its own, without the complication of side effects. The team found that E. coli-infected pups later injected with LPS had significantly lower concentrations of cytokines called interleukins than control pups (they tested 32 PUPS in all). Immune ce...

Researchers discover molecular mechanism that desensitizes us to cold

... the membrane protein that allows us to sense cold works and how this protein becomes desensitized so that one no longer feels the cold. The study, published this week as an advance online publication by Nature Neuroscience, focused on a specific region of the cold receptor which is found in many other rec...

Not-for-profit publishers call NIH public access rule a missed opportunity

...rved if NIH created an enhanced search engine that works like Google to crawl the journals' full text articles and link to the final published articles residing on the journal websites. This would offer significantly more assistance to those seeking medical research results than a database of NIH-funded ma...

Pulsating ultrasound enhances gene therapy for tumors

...eases the uptake of drugs. Now we've shown that it works for genes and we're making the case that there's a connection between the two." Other methods currently being investigated for enhancing gene delivery, such as lasers and electric current, are limited to surface lesions or require needles to be inse...

Biodiversity hotspots identify conservation priorities

...rity areas that have been identified." CI already works in most of the existing hotspots and plans to expand its programs into some of the new hotspots, including the Madrean Pine-Oak Woodlands. "We have already begun looking seriously at the U.S.-Mexico border area," Mittermeier said. "We are trying to i...

Multi-purpose protein regulates new protein synthesis and immune cell development

...te stages of B lymphocyte development, and that it works through a different mechanism at each stage," Zhang says. "This is the first indication that a sensor for protein folding in the endoplasmic reticulum can also signal the nucleus to regulate gene rearrangements required for B cell differentiation," ...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...from invading viruses or other genetic threats. It works by interrupting messenger RNA as it transfers the genetic code for a protein from the nucleus to the site in the cell where the protein is synthesized. To trigger RNA interference and silence a gene, short bits of double-stranded RNA are introduced ...

Two are better than one

...ling. "Understanding how HER receptor degradation works could enhance weak therapeutic efficacy, as well as provide ways to sensitize patients to overcome inherent or acquired resistance to cancer treatment," says Yarden. Prof. Yosef Yarden's research is supported by the Y. Leon Benoziyo Institute for Mo...

Canada approves marijuana-based pain spray

...edical Advisor, MS Society of Canada. How Sativex works Sativex is administered through a spray pump under the tongue or on the inside of the cheek, providing reliable, self-administered pain relief. The spray formulation allows for more flexible dosing than an oral tablet, well suited to the variable nat...

Used in a new way, RNA interference permanently silences key breast cancer gene

...n of genes in a variety of cells and organisms. It works by introducing a small double-stranded RNA (RNAi) that specifically targets a gene's product, its messenger RNA. This action then blocks translation and production of the protein that the gene encodes. In this study, the researchers used a lentiviru...

New understanding of DNA repair may pave way to cancer treatments

...at cause breaks in DNA. A likely way in which ATF2 works is to halt the cell's cycle to allow repair of damaged DNA before such damage becomes permanent." Ronai and his colleagues are now determining how molecules like ATF2 can balance their dual roles. "High doses of radiation, as well as changes that ta...

Roche clinical trial registry and results database launched

... adherence to regulations of clinical trials Roche works to ensure that all its activities are performed in accordance with ethical and regulatory requirements. Moreover, Roche is strongly committed to verifying adherence to compliance policies. Adequate and ongoing peer review is a key prerequisite for ma...

New tumor-suppressor gene discovered

...Penn State, which also has discovered how the gene works with another tumor suppressor to control tissue gr...nction, which is to make a particular protein that works in particular ways. "A mutant gene is not going to make the protein product that the normal gene is ...

Chromosome Deletion Predicts Aggressive Neuroblastoma

...abstract in pediatric cancer research. Dr. Attiyeh works in a comprehensive neuroblastoma research program at Children's Hospital, directed by John M. Maris, M.D., the senior author of the abstract. Co-authors of the study, in addition to Drs. Attiyeh and Maris, included Katherine K. Matthay, M.D., of the...

At long last, scientists figure out how plants grow

...m report a virtually identical result. "How auxin works has been a holy grail in plant science," said Estelle, who led the research. "This was something even Charles Darwin considered, if only in spirit. That we've all been trying to figure it out for so long makes this latest discovery very satisfying." ...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

... Taxol, used to treat a wide spectrum of cancers, works by interrupting the reorganization of the cell that is necessary if it is to divide. While it was known that the primary effect of the drug is to interfere with assembly of the spindle that pulls nuclear chromosomes apart during cell division, Ueno a...

MUHC researchers make cancer target breakthrough

...tures and in mice. "Discovering that the antisense works in animal models is a major step forward, and give...l of toxicity," says Dr. Rozen. "An antisense that works in harmony with other drugs, and in such low doses, is a significant breakthrough in cancer research...

Stanford gut check shows diversity of intestinal ecosystem

...et. This is just the tip of the iceberg." Eckburg works with David Relman, MD, associate professor of medicine (infectious diseases and geographic medicine) and of microbiology and immunology. Relman's lab at the Veteran Affairs Palo Alto Heath Care System specializes in microbial pathogen discovery and h...

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