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Tag: "withdrawal" at biology news

New compound prevents alcoholic behavior, relapse in animals by blocking stress response

...gh several cycles of heavy alcohol consumption and withdrawal to create dependency, as well as animals selectively bred to consume more alcohol. Injections of MTIP prevented excessive drinking of alcohol in both cases and eliminated the rats?susceptibility to relapse under stress. Yet the compound did not affec...

Proteins necessary for brain development found to be critical for long-term memory

...The shocks cause the animals to exhibit heightened withdrawal reflexes days and weeks after the shocks are over. When the animals are shocked, a brain chemical known as serotonin is released that promotes the formation of a long-term memory associated with the shocks. However, when Carew and his colleagues bl...

Scientists take 'snapshots' of enzyme action

...assing and result in psychological effects such as withdrawal and depression. People with defective FMOs might also suffer additional side effects from drugs, industrial compounds, or other chemicals. ...

Pest control research leads to pain control discovery

...EH inhibitors reverse hyperalgesia and bring their withdrawal reaction back into the normal range. Hammock said "these sEHIs are of similar or greater potency in reducing inflammation in rodents to Vioxx, but also when combined with Vioxx can dramatically reduce the concentrations of the Cox 2 inhibitor neede...

Mice lacking social memory molecule take bullying in stride

...nd post-traumatic stress disorder, in which social withdrawal is a prominent symptom. Drs. Olivier Berton and Eric Nestler, University of Texas Southwestern Medical Center (UTSMC), and colleagues, report on their study in the February 10, 2005 issue of Science. Coursing from a hub in the center of the brain...

It's in the genes: Study opens door to new treatment of the blues

...nderlying psychiatric disorders that have a social withdrawal component, such as social phobia, depression and p...Trofanil), were successful in reversing the social withdrawal in these mice. But the successful use of the gene therapy approach to block the expression of the BD...

Depression model leaves mice with molecular scar

In addition to triggering a depression-like social withdrawal syndrome, repeated defeat by dominant animals leav...or (BDNF) to normal levels and reversed the social withdrawal behavior. BDNF in the hippocampus has been linked to memory, learning and depression, but Nestler sa...

Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

...s, called MCF-7:5C, that are resistant to estrogen withdrawal and that undergo apoptosis when treated with very small concentrations of estradiol. The researchers treated MCF-7:5C cells with estradiol and fulvestrant, and they also injected the cancer cells into mice to study estradiol's influence on apoptosis ...

Hepatitis C complicated by morphine withdrawal

...ty of Pennsylvania have demonstrated that morphine withdrawal complicates hepatitis C by suppressing IFN-alpha-m...us replication. The paper by Wang et al., Morphine withdrawal enhances hepatitis C virus (HCV) replicon expression, appears in the November issue of The American ...

Researchers discover new route to hemoglobin synthesis

... opiate, the addition of phenobarbitone may reduce withdrawal severity, but more research is needed using a high...to opiates in the uterus develop clinical signs of withdrawal "The interesting information," Osborn says, "suggests that these infants can be treated without adm...

Opiates Better Than Sedatives For Treating Newborns In Withdrawal

... opiate, the addition of phenobarbitone may reduce withdrawal severity, but more research is needed using a high...to opiates in the uterus develop clinical signs of withdrawal "The interesting information," Osborn says, "suggests that these infants can be treated without adm...

FDA Announces Series of Changes to the Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

... began after Merck conducted a voluntary worldwide withdrawal of its COX-2 selective NSAID, Vioxx (rofecoxib), in September 2004. FDA will carefully review any proposal from Merck for resumption of marketing of Vioxx. These actions are based on the available scientific data, including data accumulated since th...

Key Trigger Of Opioid Withdrawal Symptoms Found

...ain's neuronal machinery that triggers some of the withdrawal symptoms of opioid drugs like morphine and heroin....r habits. To zero in on the machinery underlying withdrawal symptoms, researchers led by Elena Bagley and Macdonald Christie of the Pain Management Research Ins...

Alcohol's effects on gene expression in the central nervous system

...ol, development of alcohol dependence, and alcohol withdrawal severity," he said. "For the average reader, knowing which genetic profiles might contribute to excessive alcohol drinking could be used to identify risk factors that contribute to alcoholism and alcohol abuse, and could aid in the development of sel...

Controversial drug shown to act on brain protein to cut alcohol use

...ent advocates impressed with itsability to reverse withdrawal symptoms and craving for alcohol andvarious drugs of abuse. It has been used outside of the U.S. to treataddiction by American and other clinicians. But its side effects,including hallucinations, which made it popular in the 1960s drugculture, and ev...

UAB scientists discover the origin of a mysterious physical force

... adherence of substances to cell membranes and the withdrawal of proteins. Both of these are fundamental in biomedical research, since a substantial part of the process of designing new drugs is based on understanding how substances penetrate cell membranes to enter cells. These drugs are often proteins designe...

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