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454 sequencing identifies HIV drug resistance at early stage

...ediction of early antiretroviral treatment failure with strong statistical significance. “Current genotyp...hile treatment of HIV has been largely successful, with dramatic increases in survival over the last decade, a significant number of patients develop drug r...

Exploring the dark matter of the genome

...selves, but it's harder to know how shorter pieces with many repeating sequences, typical of heterochromat... genes were assembled by comparing numerous copies with unique or sufficiently distinctive sequences. The assembly was checked by matching it to clones of l...

In nature, proteins sweep up nanoparticles

...d into the watery environment, it readily combines with metals, in this case zinc, to form nano-sized biom...henomenon that occurs within a cell, or in contact with it. But in this case, we see an intimate association of proteins and minerals that takes place as fa...

University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts

...ue, exhibiting tissue formation that is consistent with a mature artery. According to Dr. Vorp, these findings in a rat demonstrate the feasibility of developing MDSC-seeded tissue-engineered vascular grafts for eventual human application. “The next step is to demonstrate the use of the tissue-engineer...

Marine phytoplankton changes form to protect itself from different predators

...s to consume. Lead author Jeremy D. Long, along with collaborators Gabriella W. Smalley, Todd Barsby, J...as been controversial in the scientific community, with some arguing that Phaeocystis makes a good food source for higher creatures in the cold oceans, whil...

Warning from Asian bees

...ons, pumpkins, and even cotton are more productive with their help. “And almond crops rely entirely on ...illion to America. However, this is in contrast with the rest of the local industry, beset by poor yields and low prices, brought on by the drought. “...

Research finds that circadian rhythms dominate all life functions

... is essential for understanding how genes interact with and regulate health and disease. Colorado State Un...rstanding gene oscillation may provide researchers with clues for developing ways to treat people who overeat because of impaired leptin signaling. Circad...

Potent possibilities for parasite attack

...iguring mucocutaneous leishmaniasis, respectively, with the sequence they produced in 2005 for L. major, w...ect they include key genes involved in interacting with the human host - where the battle between parasite and patient is fought and where rapid response is...

Runners -- Let thirst be your guide

...d potassium and carbohydrates, are basically water with a few additives. “There’s a misconception among th... kidney can normally excrete up to a liter an hour with an AVP level of zero, but when you’re exercising, the AVP is telling your kidney to excrete a volume...

Gene responsible for common hearing loss identified for first time

...sociation. “Combining the data from both groups with a common odds ratio gave a very significant result, from which we were able to conclude that we were the first to identify a gene that influences the susceptibility for otosclerosis”, said Ms Thys. “And, as further evidence, we were also able to sh...

Mutating the entire genome

...nd limbs in the mutant mouse on the left, compared with the skeleton of a normal mouse on the right. The n...e Genetics. Capecchi and Wu conducted the research with two other University of Utah human geneticists: Guoxin Ying, a postdoctoral fellow, and Qiang Wu, an...

Clot-dissolving agent may be beneficial in treatment of severe frostbite

...bite beginning in 2001. Patients who were admitted with severe frostbite underwent imaging studies to asse...the affected limb. From 2001 to 2006, six patients with abnormal blood flow on angiography received tPA within 24 hours of severe frostbite injury. These in...

Potato wart eyed as risk to potato production

While many may be familiar with potato late blight, the plant disease responsible ...epend on potato production, say plant pathologists with The American Phytopathological Society (APS). According to Gary Franc, plant pathologist with the ...

UCF nanoparticle offers promise for treating glaucoma

...very,” said Sudipta Seal, an engineering professor with appointments in UCF’s Advanced Materials Processin...icines penetrate into the eye, earlier experiments with nanoparticles have shown not only high penetration rates but also little patient discomfort. The mi...

Researchers demonstrate way to control tree height

... the U.S.” That aside, he said, it appears that with further research and development programs, it woul...by gibberellic acids. They were grown in the field with USDA approval, and assessed several times for variation in size and appearance. Other than reduce...

Weizmann Institute scientists develop a general 'control switch' for protein activity

...itute’s Biological Regulation Department, together with Dr. Miri Eisenstein of Chemical Research Support, ...almost completely. The method provides researchers with a simple and effective tool for exploring the function of unknown proteins, and in the future the ne...

UI anthropologist, colleagues discover remains of earliest giant panda

...pical bamboo forests. It is often found associated with the extinct elephant-like creature, Stegodon, and ...ovember to explore new cave sites in collaboration with Chinese colleagues. A Fellow of the American Association for the Advancement of Science, Ciochon is ...

Researchers discover 'acquired' DNA key to certain bacterial infection

...id. “In fact, its efficiency is close to zero. But with this ‘island’ of acquired genetic material, the ba...trast, the incidence of lung infection in patients with chronic lung diseases and cystic fibrosis is increasing. Understanding the mechanism by how M. av...

Endosome-mediated signaling in plants

... cell, by bringing signaling components in contact with their activated receptors. Drs. Geldner, Chory and collaborators now extend the range of endosome-mediated signaling into the plant kingdom. The researchers show that the growth-promoting brassinosteroid receptor (BRI1) is trafficked through endos...

Fat fish put obesity on the hook

...nn, MD, Editor-in-Chief of The FASEB Journal, “and with this model, we are a step closer to temporarily turning off or diminishing the fat-storing mechanisms that were once crucial to the survival of our species. The zebrafish has become a model animal for the study of many diseases because it has a backb...

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