New research questions basic tenet of neuron function
...fundamental mechanisms of neurotransmitter release will aid researchers in their investigations of psychiatric disorders and neurological disorders such as mental retardation, autism, depression and epilepsy, all of which have been linked to abnormal neurotransmitter function, said Dr. Kavalali. In neuro...U-M scientists find genes that control growth of common skin cancer
... treatment of this widespread disease.Their report will be published in the Jan. 15 issue of Genes &De..., called Gli2 ,effectively turning it on or off at will in the skin. As expected,expression of Gli2 resulted in BCC formation. In addition, theresearchers f...Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
...es wrong. The findings, already published online, will appear in the April print edition of Molecular Biology of the Cell, whose editors have chosen to highlight the Weill Cornell research due to its quality and broader significance to the field. "This is a kind of cellular fine-tuning, and we know that...Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine
...trains of these bacteria.?Knowingthe shape of CbpA will guide researchers in their efforts to use partor all of this protein as the basis of a vaccine against S. pneumoniae.“CbpA is a very large protein,?Tuomanen said. “Now that we know whatit looks like and how it’s put together, we can pull it apart to ...Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
...tala said. While the use of alcohol-based handrubs will continue to be an important infection control measure, it is important to recommend or require traditional hand washing with soap and water throughout each day. Researchers first had volunteers clean their hands and then contaminated their hands wit...New comparative toxicogenomics database
...trains of these bacteria.?Knowingthe shape of CbpA will guide researchers in their efforts to use partor all of this protein as the basis of a vaccine against S. pneumoniae.“CbpA is a very large protein,?Tuomanen said. “Now that we know whatit looks like and how it’s put together, we can pull it apart to ...Taking Aim With Nanoparticle PEBBLEs
...l Society in San Diego, Calif., March 17, Kopelman will describe the research that he and his collaborator...the two." Kopelman's collaborators on the work he will discuss in San Diego are Martin Philbert, professor of toxicology and Associate Dean for Research in...Genetically modified natural killer immune cells attack, kill leukemia cells
...ming) cell transplantation. In this case, NK cells will be derived from the transplant donor, expanded and genetically modified. These modified NK cells will then be infused into the patient after the transplant in order to eliminate residual leukemic cells....UCSD researchers maintain stem cells without contaminated animal feeder layers
...diatrics and the Whittier Institute, said that "it will be rather simple now to develop a specific defined...as a key factor in mediating these cellular events will help to unravel the biochemical pathways responsible for 'stemness'. An increased efficiency in the ...Scientists develop new color-coded test for protein folding
...ady to mass-produce this technology, we believe it will eventually be useful for testing other, more complicated proteins," Zare said, noting that a gold nanoparticle sensor could turn out to be a quick and inexpensive way for doctors to identify antibodies and other signs of infection in the blood stream...Probing The Promise And Perils Of Nanoparticles
...aduate students Pascale Leroueil and Seungpyo Hong will discuss their research at the 229th national meeti...s. The work that Banaszak Holl, Hong and Leroueil will discuss is one of several major research programs under way in the U-M Center for Biologic Nanotechn...Open microfluidic and nanofluidic systems
The labs of the future will be "labs-on-a-chip", i.e., integrated chemical and... micrometer or even nanometer scale. These devices will significantly change the way in which research is performed in the life sciences since they offer th...Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
... clinical trials.Lachman believes that the vaccine will address two additional safetyconsiderations “because it is built of RNA that cannot insert itselfinto the genome, and the possibility of autoimmunity to it appears tobe low, because normal cells express very small amounts of the HER2/neugrowth protei...Highly adaptable genome in gut bacterium key to intestinal health
... other microbe we know of." Next, the researchers will use germ-free mice to investigate how B. theta interacts with other members of the gut ecosystem. By defining the factors that underlie the stability of the gut ecosystem, they may be able to develop ways to manipulate the gut's bacterial community t...Amino acids in nectar enhance butterfly fecundity: A long awaited link
...article by Jovanne Mevi-Schütz and Andreas Erhardt will appear in the April 2005 issue of The American Naturalist. ...Scientists identify genetic pathways essential to RNA interference
...omeday may help to fight human disease. The report will appear in the journal Science and is receiving early online release on the Science Express website at http://www.sciencexpress.org. "The gene activation produced by RNAi is exquisitely specific, which gives it enormous potential for therapeutic appl...A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
... clinical trials.Lachman believes that the vaccine will address two additional safetyconsiderations “because it is built of RNA that cannot insert itselfinto the genome, and the possibility of autoimmunity to it appears tobe low, because normal cells express very small amounts of the HER2/neugrowth protei...Ants Genetic Engineering Leads To Species Interdependency
...tic predisposition, that determines whichcaste she will adopt.However, in two harvester ant populations in southern New Mexico,queens and workers from the same colonies are genetically verydifferent; in both species at the site, only the queens are geneticallyderived from a pure species-specific lineage, ...Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra
.... The foxes are mostly off the islands now, but we will probably continue to see the effects for a long time," Estes said. In addition to Croll and Estes, the authors of the Science paper include UCSC graduate student Eric Danner, University of Montana plant ecologist John Maron, and USFWS biologist Vern......vulnerable to intervention. "We hope this project will help vaccine researchers find the besttargets agai...January 7th issue of Science. "Thestudy's findings will help scientists identify parasite genes that areinteracting with the host as well as new gene target...