New research questions basic tenet of neuron function
...tardation, autism, depression and epilepsy, all of which have been linked to abnormal neurotransmitter function, said Dr. Kavalali. In neuronal cell cultures, the researchers labeled synaptic vesicles with a fluorescent dye and observed how and when the vesicles released neurotransmitters, both when the n...U-M scientists find genes that control growth of common skin cancer
...is aneffective approach to treating these cancers, which generally have aslow growth rate and seldom spread... investigators used genetically engineered mice in which they couldmanipulate expression of an Hh pathway component, called Gli2 ,effectively turning it on o...Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
...responsible gene with bits of RNA; and microscopy, which looks at the activity of individual living cells b...sis." "This had literally never been done before, which is one of the reasons the journal editors are so excited about this study," he said. The new techno...New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
...es and those sequences are separated by regions in which RNA is transcribed more scarcely. All of the data is freely available . "The findings of this study compel us to reconsider how the genome is organized and regulated," said Thomas Gingeras, Vice President for Biological Research at Affymetrix and......so produces a natural compound called migrastatin, which appears to inhibit cell migration. Natural migrastatin's effect is relatively weak, but Dr. Huang suspected the molecule might be manipulated into something more potent. In collaboration with the laboratory of Dr. Samuel Danishefsky at the Memorial ...Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine
... CbpA, binds to a molecule on thecell called pIgR, which takes antibodies from the bloodstream on oneside o...ds in order todetermine the shape of this protein, which undergoes changes as itinteracts with pIgR,?said Rensheng Luo, Ph.D., a post-doctoral fellowin St. J...Critical role in programmed cell death identified
...er to pinpoint. In worms, scientists know exactly which cells are dying, and when and where. During develo...ure makes it possible to identify mutant worms, in which cells that should have died instead live. Worms whose cell death program is blocked survive, at leas...New comparative toxicogenomics database
... CbpA, binds to a molecule on thecell called pIgR, which takes antibodies from the bloodstream on oneside o...ds in order todetermine the shape of this protein, which undergoes changes as itinteracts with pIgR,?said Rensheng Luo, Ph.D., a post-doctoral fellowin St. J...ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors
...ere are some 350 species of parrots, 80 percent of which have red in their plumage. They found a suite of five molecules, called polyenal lipochromes (or psittacofulvins), that color parrot plumage red in all of the species studied. "We've uncovered a system where all red parrots use the same set of mole...Elephants imitate truck noises, other animals
...because it enables an open communication system in which animals and humans develop new signals with shared associations. Recent playback experiments conducted by Karen McComb of Sussex University have shown that elephants can remember the calls of a large number of other elephants. The new findings sugges...Genetically modified natural killer immune cells attack, kill leukemia cells
...chnique triggered growth of NK cells specifically, which greatly simplified the ability of the researchers ...e was designed to recognize a protein called CD19, which is found on the surface of leukemic cells. When the receptor bound to CD19 on leukemic cells, it set...Transport System Smuggles Medicines Into Brain
...ere are some 350 species of parrots, 80 percent of which have red in their plumage. They found a suite of five molecules, called polyenal lipochromes (or psittacofulvins), that color parrot plumage red in all of the species studied. "We've uncovered a system where all red parrots use the same set of mole...Scientists develop new color-coded test for protein folding
... nanoparticle folds or unfolds. The new technique, which works on the same principle as ordinary pH tests t...le when the pH reached 5.8 and light blue at pH 4, which is close to the acidity of wine. Lab analysis revealed that additional hydrochloric acid was causing...Placenta Is A Rich Source Of Blood Stem Cells
...topoietic (blood-forming) stem cells. These cells, which appear very early in development, are able to gene...ing aorta. No role was suspected for the placenta, which has been seen as simply a place for nutrient exchange and waste removal between mother and fetus. Bu...Open microfluidic and nanofluidic systems
...al reagents. Directly accessible surface channels, which can be fabricated by available photolithographic m...These devices will significantly change the way in which research is performed in the life sciences since they offer the ability to work with much smaller re...Researchers discover molecule that causes secondary stroke
...condition, but also a diagnostic test to determine which hemorrhagic stroke survivors are at greater risk." Several spinal fluid components were suspected of causing the vasospasm, Dr. Clark explains. They included hemoglobin, bilirubin and peroxidized lipids, and a group of bilirubin oxidation products t...Study shows nanoshells ideal as chemical nanosensors
...as little as a few molecules of atarget substance, which could be anything from a drug molecule or a keydisease protein to a deadly chemical agent."About 1/20th the size of a red blood cell, nanoshells are about thesize of a virus. They are ball-shaped and consist of a core ofnon-conducting glass that is c...Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
...sed in this study is a“viral-vectored?approach, in which a naturally occurring virus isre-engineered to be ...rus called VEE, forVenezuelan equine encephalitis, which in its natural form can causedisease in horses.Researchers at AlphaVax, Inc., a privately held biote...Elephants imitate sounds as a form of social communication
...because it enables an open communication system in which animals and humans develop new signals with shared associations. Recent playback experiments conducted by Karen McComb of Sussex University have shown that elephants can remember the calls of a large number of other elephants. The new findings sugges...Amino acids in nectar enhance butterfly fecundity: A long awaited link
... evolved intriguing mechanisms and attractants, of which nectar is best known. Thirty years ago, researchers discovered that nectars of flowers pollinated by butterflies contain substantial amounts of amino acids. Recent experiments have shown that butterflies actually prefer nectars with a high amino aci...