New Clues Add 40,000 Years to Age of Human Species
...ent origin of modern humans in Africa, yet one for which the age and provenance of the fossils was repeated...ougall collected rocks containing volcanic debris, which McDougall dated to approximately 195,000 years old. Forty years ago, radiometric dating methods wer...A bacterial genome reveals new targets to combat infectious disease
...an manufacture some essential metabolic coenzymes, which do not appear to be made by its host. Conversely, it cannot synthesize amino acids and a variety of other vitamins and cofactors, and probably depends on the nematode to supply them. One discovery of possible significance is the presence in the bact...Spider Venom Could Yield Eco-Friendly Insecticides
... brew of more than 100 chemical compounds, most of which are toxic to insects, but not vertebrates. King is studying the molecular structures of the toxins that selectively target the nervous systems of insects to understand the toxins' mechanism of action at the cellular level. Because these toxins do not...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
...prehensive Cancer Center developed the assessment, which they call a functional diffusion map. They used a ...ll death; other areas saw a decrease in diffusion, which Ross said could be accounted for by the swelling some cells undergo before dying; and in some partic...Gene variations explain drug dose required to control seizures
Determining which variants of particular genes patients with epileps...itions, such as Parkinson's disease and cancer, in which patients' drug dosage requirements vary substantially, they added. Rigorous clinical study is requi...Solution to Pollution: New Bacteria Eats Toxic Waste
...will then participate in the annotation process by which genes in the sequences will be identified. The researchers will be able to understand the genetic material that allows these bacteria to degrade the PAHs and survive in the soil. Such knowledge may help researchers better understand and utilize the o...Scientists collaborate to assess health of global environment
...the March 30 press conference in Washington, D.C., which will focus on the implications for the United States and international business institutions. Funded by the Global Environment Facility, the United Nations Foundation, the David and Lucile Packard Foundation, the World Bank and others, the Millenniu...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
... to degenerate. Using genetically altered mice in which the gene for the enzyme had been rendered nonfunct... dystrophies include many genetic diseases, all of which are characterized by progressive weakness and degeneration of the skeletal muscles which control mov...Enzyme shown to help protect genomic stability
... for aging-related diseases, the most prominent of which is cancer. For this reason, insights into the mech...r regions of the genome. A report on the research, which was conducted in yeast, appears in the February 18 issue of Molecular Cell. "There are regions of t...Scientists decipher genome of fungus that can cause life-threatening infections
...ternative splicing" and"antisense" transcripts, in which the gene on one strand of the DNAdiffers from the ... transposons (moveable elements)within the genome, which may account for the genome rearrangementsoften observed between different Cryptococcus isolates.TIGR...Purdue proves concept of using nano-materials for drug discovery
...aled at the bottom with a material called alumina, which contains numerous pores measured in nanometers, or...iveness of new drugs to treat diseases. Membranes, which surround cells and regulate the movement of molecules into and out of the cells, contain a variety o...In the sea slug's defense against lobsters, confusion is key
...enses against its predators, but the mechanisms by which such chemical attacks actually work against their intended targets are not well understood by researchers. New work has now shown that such chemical defenses can involve modes of trickery that had not previously been appreciated as components of chem...Scientists discover the cellular roots of graying hair
...search is revealing the life cyclesof melanocytes, which are the cells that become cancerous in melanoma,we...ncreasing in the past several decades.Melanocytes, which manufacture and store the pigment that combines withhair-making cells called keratinocytes to color ...Researchers identify target for cancer drugs
...s gangbusters," says Sabatini. The exact means by which Akt switches on when it reaches the cell membrane has only been partially understood. As a result, researchers have lacked a clear idea about how to prevent the process. However, in the February 18 issue of the journal Science, researchers from the S...Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
...obia, that reduce atmospheric nitrogen to ammonia, which is subsequently used by the plant for growth and colonization of nitrogen-poor soils. Symbiotic nitrogen fixation is important for sustainable agriculture and contributes millions of tons of reduced nitrogen to crops and pastures each year. As repor...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
...search is revealing the life cyclesof melanocytes, which are the cells that become cancerous in melanoma,we...ncreasing in the past several decades.Melanocytes, which manufacture and store the pigment that combines withhair-making cells called keratinocytes to color ...Scientists rid stem cell culture of key animal cells
... connective tissue cells that form the matrix upon which stem cells grow. The mouse feeder cells were an i...ls extracted from mouse tumors. Serum replacement, which is bovine in origin, is the other animal material still needed to culture stem cells. Xu became int......search is revealing the life cyclesof melanocytes, which are the cells that become cancerous in melanoma,we...ncreasing in the past several decades.Melanocytes, which manufacture and store the pigment that combines withhair-making cells called keratinocytes to color ...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...enes. What makes them do different things involves which genes are turned on," notes Bradley Bernstein, a p...rprise involves clusters of so-called "HOX" genes, which apparently work in concert to control how we develop in the womb. Instead of being activated individ...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
... regulate the development of thatbrain region, and which of them to investigate as possible causes ofbrain ...velopment of the particular areas or structures in which they wereuniquely expressed.Stiles is pursuing TF’s that direct the formation of astrocytes, whichar...