Scientists detect probable genetic cause of some Parkinson's disease cases
...in by the researchers from the Basqueword dardara, which means tremor, a major symptom of Parkinson'sdiseas... of this large groupof families and sibling pairs, which is proving to be an invaluableresource for these studies," says Diane Murphy, Ph.D., a programdirect...Computers to be used to find blueprint for new influenza drug
...ning the behaviour of atoms of the influenza virus which attack cells, and atoms of the throat cells that a...s. “We often think of flu as just a nasty illness which puts us in bed for a few days. But some outbreaks can cause death on a large scale ?the world-wide o...Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
...ons into monkeys treated with anagent called MPTP, which is considered a primate model for Parkinsondisease. These transplanted cells were able to function as DA neuronsand diminished Parkinsonian symptoms.In an accompanying commentary, J. William Langston from the Parkinson'sInstitute, California, describ...A much-needed shot in the arm for HIV vaccine development
...h a set of milestones, and a transparent processby which successes and failures will be measured."Related Articles : A Shot in the Arm for AIDS Vaccine Research. The Global HIV/AIDS Vaccine Enterprise: Scientific Strategic Plan. A Strategy for Developing an HIV Vaccine ....Newly discovered virus linked to childhood lung disorders and Kawasaki disease
...virus is one of thenumerous coronaviruses, most of which infect animals. In humans,coronaviruses have been ...count for someof the many respiratory diseases for which a causative agent isunidentified, and may have a role in Kawasaki disease, the most commoncause of a...Inexpensive, mass-produced genes core of synthetic biology advances at UH
...of creating the most primitiveof living organisms, which requires synthesis of several thousandgenes, would be prohibitive, costing millions of dollars and years oftime. The system developed by Gao and her partners employs digitaltechnology similar to that used in making computer chips and therebyreduces c...New Technique for Tracking Gene Regulators
...d many tens of thousands genes. Trying toascertain which of these genes CREB regulates by more traditionalm...ts a largenumber of very short DNA “tag?sequences, which all have the same startsequence of CATG plus 16 additional unknown bases. The scientists then“glue?t...Bound for destruction: Ubiquitination protects against improper Notch signaling
...extendsthrough both sides of the cell membrane and which is capable ofinteracting with a ligand partner, su...pecies from human toroundworm. In all processes in which it participates, Notch signalingshows the ability to sense a small change in cell fate and amplify i...HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
...ed 24 cases of heart rhythm disturbances -- all of which were associated with protease inhibitors. They investigated the hypothesis that the widely-used protease inhibitors may, in fact, be linked to the development of heart rhythm problems through the mechanism of blocking a channel. Ultimately researche...Combination therapy boosts effectiveness of telomere-directed cancer cell death
... cancer cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep dividing. Telomerase is not used by healthy cells, andhas been identified as a logical target for anticancer therapeutics.However, recent studies indicate that for this therapy to be effectiv...GATA: a graphic alignment tool for comparative sequence analysis
... cancer cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep dividing. Telomerase is not used by healthy cells, andhas been identified as a logical target for anticancer therapeutics.However, recent studies indicate that for this therapy to be effectiv...Whole genome fine map of rice completed
... draft sequence of the Chinese hybrid rice genome, which was published in the Journal Science in 2002, CAS researchers have recently finished the fine map of the rice genome. In an article published by the recent issue of PLoS Biology (Vol.3 Issue 2, 2005), scientists led by the Beijing Institute of Genomi...Research on Worms Yields Clues on Aging
... mutant worms to further pin down the mechanism by which theanticonvulsants increased longevity.The worms' mutated genes affect the function of sensory neurons thatregulate the release of an insulin-like hormone. "Sensory inputs fromthe outside regulate the level of insulin signaling inside the body,which ...“Nano-scissors?laser shows precise surgical capability
...vestigate nerve regeneration inmice and zebrafish, which have complex nervous systems. This laserallows researchers to study nerve cells at their most basicevolutionary form, opening the door to other experiments on genetic andmolecular factors that determine whether damaged nerve cells regrow.Ben-Yakar de...U-M scientist to talk about tissue engineering at AAAS
...iven to patients with osteoporosis, a condition in which bone quality declines leaving them fragile and prone to breaking. Parathyroid hormone stimulates bone growth in these patients, and Krebsbach sees potential to use it for similar gains in tissue engineering new bone. Bone morphogenetic proteins help...Genome-wide mouse study yields link to human leukemia
... for patient care, since we know that methylation, which alters gene function, can be reversed," says Christoph Plass, senior co-author and a member of the OSUCCC's Molecular Biology and Cancer Genetics and Experimental Therapeutics Programs. While it was Caligiuri's laboratory that designed the mouse mod...The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
... further eliminating the blurry and unwanted light which prevented scientists from looking deep into tissues in the past. The entire procedure is very fast and in a computer supported post-processing step, one or more stacks of images are assembled into a high-resolution film. Another advantage of SPIM is...Iron Deficiency Sparks Dramatic Changes In Gene Expression
...e. The most widelyrecognized symptom is anemia, in which too few red blood cells areproduced, and the body is deprived of oxygen needed for energymetabolism. Iron deficiency causes wide-ranging symptoms from fatigue,weakness and cognitive deficits to serious heart complications anddevelopmental disorders. ...Scientists find missing enzyme for tuberculosis iron scavenging pathway
...the sequences of genes for other proteins (most of which are from different species) in sequence databases....ecalls Dr. Baker. "Mycobactin is a small molecule which binds iron very tightly. Bacteria synthesize it so that they can acquire the iron they need to grow ....... The compact retrovirus encodes just 14 proteins, which play different roles in promoting viral infection ...st’s cellular machinery—including RNA polymerases, which carry out transcription—to copy its RNA genome into DNA and infiltrate human chromosomal DNA. Once t...