Protein discovery could unlock the secret to better TB treatment
... this protein will lead the way to designing drugs which enable treatment of dormant and multidrug resistant TB. In England and Wales around 400 people die each year from the disease. The top challenge for TB control in the European region is multidrug-resistant TB (MDR-TB). Eight per cent of the bacteria...Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
...pair. Insufficient repairof UV-induced DNA damage, which for example may occur after excessiveunprotected s...ough mice do not ordinarily produce these enzymes, which removeeither CPD or 6-4PP lesions by using visible light as an energy source,expression of the trans...W.M. Keck Foundation funds study of friendly microbes
...or facet of the University's BioMed 21 initiative, which aims to translate genomic science into patient car...olites. "We very grateful to the Keck foundation, which has committed itself to funding high-risk projects designed to overcome key obstacles in emerging fi...Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
...te of instruments was used to gather data, some of which hadnever before been collected. "No one had measured the concentration ofhydrogen in the hot springs before because the technology didn't existuntil about seven years ago. Now we can detect very low-levelconcentrations of hydrogen in water," Spear ex...It's not all genetic: Common epigenetic problem doubles cancer risk in mice
...copy of IGF2 that should be silent depends only on which parent it came from, a situation called genomic im...use tumors directly, but it creates an environment which is ripe for cancer to start." Because precursor cells in the colon's lining had been identified as ...Dysentery uses 'sword and shield' to cause infection
... Pasteur, Paris, found that shigella, the bacteria which causes dysentery, is able to invade cells, while stopping any response from the immune system. They found that shigella was able to infect cells by using a secretion system to inject proteins into human cells, (the sword), while lipopolysaccharide (...Novel technology detects human DNA mutations
... Single Nucleotide Polymorphism (SNP) genotyping, which is the direct detection of a particular gene and the extent to which it is normal or mutated. The technology, reported in the February 2005 (Volume 33, Number 2), issue ...Topical treatment shown to inhibit HIV and herpes simplex virus infection
...iral activity within the human vagina. The study, which was funded by the National Institutes of Health (NIH) investigated the efficacy of PRO 2000, a topical microbicide under development by Indevus Pharmaceuticals, Inc. "There is an urgent need for the development of safe and effective vaginal microbic...Priming embryonic stem cells to fulfill their promise
... extracellular matrix proteins as a way toidentify which combinations were optimal in producing differentia...ossible combinations of these proteins, any one of which could formthe optimal "niche" for a desired type of differentiated cell.In their experiments, the UC...Growth in the sea comes down to a struggle for iron
...studied the sinking rate, the slow process through which aggregations of diatoms sink into the deep sea, taking their carbon with them. The Kilo Moana returned to Hawaii after spending 42 days at sea. Early results suggest that the struggle for iron may indeed follow something like what happens in the soi...New, automated tool successfully classifies and relates proteins in unprecedented way
...tures and not on features chosen by the human eye, which isunreliable. By automating the clustering of prot... living cells using a technologycalled CD tagging, which was developed by Jonathan Jarvik and PeterBerget, both associate professors of biological sciences a...New binding target for oncogenic viral protein
...virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cance...ors. "Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivation by Large T," explained Dr. Markus Welcker, the study'...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
...nta and its blood vessels, or high blood pressure, which damages vessels." In addition, many other factors ...les with males, dating the day of their pregnancy, which lasts three weeks. They separated the mothers into two groups. The control group ate as much chow as...Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
...he muscles ofthe legs, especially during exercise, which causes pain, aching,cramping or fatigue in the mus...cells include endothelial progenitor cells (EPCs), which isthe type of cell needed to make new blood vessels and to repair damagedones.Patients in the clinic...Fox Chase Cancer Center scientists identify immune-system mutation
...aturation of T cells involves key branch points at which cells choose one of two different pathways, going ...helper T cells carry a surface protein called CD4, which is attracted to class II MHC. Killer cells carry the CD8 protein, attracted to class I MHC. However,...Controversial drug shown to act on brain protein to cut alcohol use
...ns. But its side effects,including hallucinations, which made it popular in the 1960s drugculture, and evid...drinkers. They then withheld alcohol fortwo weeks, which normally leads to greatly increased drinking when whenalcohol is again available. When they administ...Neuronal 'traffic jam' marks early Alzheimer's disease
...en stimulate further production of A-beta peptide, which may further poison the machinery." Goldstein theorized that Alzheimer's disease might develop spontaneously in people without an overt genetic defect, as the transport machinery in their neurons breaks down with age. "A person could have a predispos...Termites feed through good vibrations
...se their ability to detect vibrations to determine which food source is most suitable. The termites can als...that made by the termites chewing the large block, which Dr Evans broadcast into small blocks and the scientists found that the termites had no preference fo...Current human embryonic stem cell lines contaminated UCSD/Salk team finds
...as also discovered the exact cellular mechanism by which this occurs. Instudies with one of the federally ...allowed todifferentiate into embryoid bodies (EB), which is the first step inpreparing them for potential use in humans, the percentage of totalsialic acids ......ticles (55 percent) and data-on-file (19 percent), which is a reference to an unpublished company document....nformation such as the Physician's Desk Reference, which annually provides information on drug usage, warnings and drug interactions; government documents; o...