Male circumcision reduces risk of HIV transmission from women to men
...wereHIV-positive. However, in some areas of Africa where HIV infectionrates are highest, multiple, concurrent partnerships are more commonthan monogamous couplings. Past studies of monogamous couples foundthat the probability of HIV transmission per-act of sexual intercoursewas on the order of one in 1000 ...Scientists detect probable genetic cause of some Parkinson's disease cases
... forms ofdisease, but in typical sporadic disease, where there is no strongfamily history, could lead to earlier detection of Parkinson's disease.Further study of how this gene works also might help scientistsidentify new treatments."In addition to Dr. Singleton, the collaborative work was spearheaded byWi...Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
...tem cells and transplanted into areas of the brain where these neuronshave degenerated in a monkey model of Parkinson disease, can reverseparkinsonism. Their results appear in the January 3 issue of theJournal of Clinical Investigation. Studiesof animal models of Parkinson disease as well as clinicalinves...Ecological destruction fuels emerging diseases
...'re always behind the curve, because we don't know where these things are coming from." In fact, while parasites like malaria are well known, we may have identified only a fraction of the total number of the world's parasites, and the prospect of cataloguing them poses a daunting technical challenge. Sinc...Study Links Ebola Outbreaks To Animal Carcasses
... is improved awareness of this risk in communities where bushmeat is still a source of sustenance and conti...f potential outbreaks often occur in remote areas, where roads are barely usable and communications limited," added Karesh. "Conservation organizations such ...New Technique for Tracking Gene Regulators
Finding out where gene-regulator proteinsbind to DNA and identifying...r technique inthe December 29, 2004 issue of Cell, where they describe thehuman-genome binding sites of a regulator protein known as CREB.“Though scientists ...U-M scientist to talk about tissue engineering at AAAS
...h for the wound at the donor site and for the site where it is implanted. In addition to discussing the sometimes-messy real world applications of tissue engineering, Krebsbach plans to talk at AAAS about the potential for combining seemingly unrelated therapies to improve the benefits of tissue engineeri...Finding Cures For Tropical Diseases: Is Open Source An Answer?
...ders. The model thus fails in thedeveloping world, where few patients can afford to pay patented pricesfor ...s a decentralized,Web-based, community-wide effort where scientists from laboratories,universities, institutes, and corporations can work together for acommo...Scientists find missing enzyme for tuberculosis iron scavenging pathway
... ?it is secreted out into the external environment where it scavenges iron and then (with iron bound to it) it is taken up by the bacterium again." Although Rv1347c is not involved in antibiotic resistance, it still remains a target for the design of new anti-TB drugs. "Enzymes that synthesize mycobactin ...Live Recombinant Adenovirus Vaccine Technique Explored
...cial for people living in the developing countries where resources are limited. Their research was made available online March 14, 2005, in advance of publication in the Proceedings of the National Academy of Sciences. “Many vaccines are expensive to manufacture, require trained personnel to administer an...Marburg virus disease in Angola - update
...oviding assistance in infection control in Luanda, where training will be provided for health care staff from all provinces in the country. The Canadian National Microbiology Laboratory will be setting up a mobile laboratory in Uige and CDC will be providing laboratory support in Luanda. UNICEF is carrying......Using whale samples from the Japanese meat market, where Antarctic minke whales killed for “scientific rese... live on them,?says Smith. In the North Atlantic, where only 10% of historic populations of the great whales are estimated to still survive, Smith speculate...Dinosaur DNA? New Patent Covers Degraded DNA recovery
...e first applications could be in forensic science, where time, the traumatic circumstances of a crime scene or the environment has caused DNA samples to become degraded. "We hope this gives criminal investigators another tool to re-open cold cases or revisit crime scenes, stringing together strands of deta...Researchers reveal the infectious impact of salmon farms on wild salmon
...dling wild salmon populations in British Columbia, where the study took place. In Europe, transfer of parasites is generally accepted as a significant threat to adjacent wild populations ?although European studies have not measured the direct transfer of sea lice from farms to wild salmon. However, a bitt...Molecular machine may lead to new drugs to combat human diseases
... fully understand. This crystal structure shows us where the best targets are for modifying genetic defects." The crystal structure of this Group I intron also will allow scientists to form models of hundreds of other introns in the same family and provide possibilities for new treatments for a wide varie...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...ually taken superlative three-dimensional pictures where we go rightthrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the embryos' developing neurons.Reinisch and company examined periodically recorded images to see whateffect, if any, the chemicals had....Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
...s is out of control in about 20 percent of cancers where it is over-expressed or activated by mutation. According to Slack, a member of the Yale Cancer Center, it is one of the most identifiable causes in some forms of lung cancer. His team has identified let-7, a natural and separately transcribed RNA tha...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...ually taken superlative three-dimensional pictures where we go rightthrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the embryos' developing neurons.Reinisch and company examined periodically recorded images to see whateffect, if any, the chemicals had....An HIV Protein Plays a Surprising Role in Gene Activation
...e-initiation complex (PIC) on the gene's promoter, where it binds to region rich in thymine (T) and adenine (A) named the TATA box. The first transcription factor to associate with the TATA box is called TFIID, a large protein complex containing a protein that binds the TATA box (aptly named the TATA-box-b...Gene variations explain drug dose required to control seizures
...said. "For most drugs we know a lot about how and where they act in the body," Goldstein said. "The current results support the idea that known drug targets, transporters and drug metabolizing enzymes are good starting points for understanding variation among patients in drug response." In Parkinson's di...