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Tag: "when" at biology news

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

... the Yalegroup's second study, which was initiated when they found evidence ofthe virus's genetic structure in respiratory secretions from an infantwith classic signs of Kawasaki disease. In addition to heart disease,the signs can include conjunctivitis, redness of the mouth or throat,rash, redness or swe...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...ppressor of Notchwas illustrated even more plainly when the lab showed that inhibitionof Nedd4 results in the upregulation of ligand-independent activationof the Notch pathway.Nedd4’s place in the greater scheme of Notch signaling became clearerwhen the group next turned to examine the interaction between...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

...hey encourage physicians to be especially thorough when performing medical exams, and in taking patient histories to be alert for signs of heart rhythm disturbances. Implications of the Findings "In no way does it mean patients shouldn't receive protease inhibitors," says Andrew Badley, M.D., associate ...

Imaging Lymph Nodes with Nanoparticles

...ignalintensity on T2- and T2*-weighted images, and when metastases arepresent there is a recognizably abnormal pattern on MRI scans. Ina previous paper published in the New England Journal of Medicine,Ralph Weissleder and colleagues described using these nanoparticles toassess lymphoid spread in patients...

U-M scientist to talk about tissue engineering at AAAS

...ach said. To heal a large wound, like that created when a cancerous tumor is removed from the jaw, that often means taking a bone graft from someplace like the hip. That approach has problems both for the wound at the donor site and for the site where it is implanted. In addition to discussing the someti...

Genome-wide mouse study yields link to human leukemia

...s, the researchers also identified a new gene that when methylated, appears to interrupt normal cell death, a process called apoptosis. "It's given us a whole new way to look at and possibly treat leukemia," says Michael Caligiuri, director of the OSU Comprehensive Cancer Center (OSUCCC) and senior co-au...

Cytoplasm affects the number of vertebrae in carp-goldfish clones

...me intriguing findings in cloned offspring created when nuclei from one genus of fish were transplanted to enucleated eggs of another genus of fish. The seven offspring, cloned from nuclei of common carp and egg cytoplasm of goldfish, were virtually identical to the nuclear donor species, Cyprinus carpio...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...ated for the first time what happens inside a cell when itis deprived of the essential nutrient iron. Iron is found abundantly inred meats, shellfish dried fruits, whole grains, spinach, seeds andother foods.Their study in yeast cells demonstrated that iron-starved cellspreserve the little iron they posse...

Learning to fight an adversary that won't stay down

...ns rightly try to keep these things in reserve for when they are really needed." ...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...e in M. tuberculosis. "What the structure showed, when combined with careful analysis of the sequence, its neighbors in the genome, and the fact that its gene was also regulated by iron, was that Rv1347c was almost certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agen...

Novel Enzyme Shows Potential As An Anti-HIV Target

...n via Tat occurs in the presence of SIRT1, but not when SIRT1’s catalytic center is removed. Experiments using cells taken from transgenic mice lacking SIRT1 demonstrated that introducing human SIRT1 enzymes increased Tat’s transcriptional effects in a dose-dependent manner, while treating cells with the ...

Scientists seek answers on what activates deadly anthrax spores

...e recent scare at two military mailroom facilities when anthrax alarms went off. The group also would like to understand another closely related bacterium, Bacillus cereus, one strain of which can produce anthrax-like symptoms. The research team includes Conn Mallett, Ph.D., Derek Parsonage, Ph.D., grad...

Dinosaur DNA? New Patent Covers Degraded DNA recovery

...nimals to unsolved crime scenes. "This discovery, when properly applied by our scientists, brings us clos...art of a scientific progression that began in 1989 when DNA was recovered from 12 samples of ancient organic remains, ranging in age from 4 to 13,000 years....

Gene therapy converts dead bone graft to new, living tissue

...ompletely dead. A serious problem arises, however, when the bone wears over time. "Everyday activities ca...ealthy, and our bones re-knit them constantly. But when the bone is dead, there is no healing, and those tiny fractures begin to accumulate until finally, p...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...ience, this finding explains howsome bacteria know when to produce a toxin that makes infection moresevere...tswere unable to explain how the Enterococcus knew when to make it.In the Science study, Gilmore and his team found that this toxin ismade whenever there is...

Researchers reveal the infectious impact of salmon farms on wild salmon

...lf a gram. "The youngest fish can be only days old when they encounter a farm," says Krkosek. "Some of these fish are so young their egg sacks haven't been fully absorbed ?even fish this small are infected." The anchored farms, open cages of closely packed salmon, are aquatic feedlots providing the ideal...

Sea skate experiment sheds light on human cell transport

...ow cellular channels, or gates, spring into action when skate red blood cells become engorged with water. ...es ?and glucose can't be moved between cells. And when channels are blocked, damaged cells can't die. This cell "suicide" is one of the body's defenses aga...

Color-blind method opens new doors in DNA sequencing

... the DNA fragments are tagged with dyes, they glow when they are struck by laser light to determine the order of one's DNA sequence. Most sequencing today is done with one laser and optics to separate the dyes into the four colors, blue, green, yellow, and red. A common problem with the technique is that...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...lam embryostudy that supports her hypothesis that, when combined, the pollutantsbromoform, chloroform, and tetrachloroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator in nervecell development. While scientists have previously studied the effectsof these pollutant...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...lam embryostudy that supports her hypothesis that, when combined, the pollutantsbromoform, chloroform, and tetrachloroethylene--a chemical cocktailknown as BCE--can act synergistically to alter a key regulator in nervecell development. While scientists have previously studied the effectsof these pollutant...

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