Controversial drug shown to act on brain protein to cut alcohol use
...strated that their drinking declined precipitously when theyreceived Ibogaine. The drug was administered e...icts to return to uncontrolled drinking ordrug use when exposed to the drug of abuse months or even years afterbreaking the habit.In this analysis, the rese...Neuronal 'traffic jam' marks early Alzheimer's disease
...stein. "We saw large swellings in their axons. And when we looked at those swellings using electron microscopy and biochemical markers, they looked just like the axonal transport blockages we saw in fruit flies." Detailed studies of the neurons revealed what Goldstein termed a "traffic jam" of transport-r...Termites feed through good vibrations
...rkers can become fertile and develop into breeders when they are isolated from their colony. Few workers developed into breeders in the experiments when they were broadcast the termite sourced signals, whereas many workers developed into breeders when a...Current human embryonic stem cell lines contaminated UCSD/Salk team finds
...d that the Neu5Gc is incorporated bythe stem cells when they are grown or derived from laboratory culturesthat contain animal sources of the non-human Neu5Gc molecule. Alltraditional culture-dish methods used to grow all human embryonic stemcells include animal-derived materials, including connective tiss...Elusive HIV shape change revealed; Key clue to how virus infects cells
... information on how the molecule rearranges itself when it encounters the CD4 receptor. "Knowing how gp120 changes shape is a new route to inhibiting HIV ?by using compounds that inhibit the shape change," says Harrison. He notes that some HIV inhibitors already in development seem to inhibit the shape c...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
..." he says. Typically, those cysts are transmitted when people ingest contaminated food or water. The disease can cause liver damage but more often causes dysentery, a severe diarrhea that is often associated with blood in the feces. Unchecked, the diarrhea associated with the disease can be fatal, especi...Antarctic ice shelf retreats happened before
...riod may have primed the ice shelf to disintegrate when the ocean currents shifted.' The scientists analysed sediments from the bottom of a freshwater lake close to the edge of the present George VI Ice Shelf. The results revealed that about 9500 years ago the ice shelf retreated, allowing the sea to flo...Timing is everything: First step in protein building revealed
...a series of experiments, the scientists found that when yeast'sprotein-building machinery recognizes the s...ibosome start making proteins."No one had any idea when eIF1 was released from the ribosome, or thatits release might serve an important purpose, so this wa...Plants, animals share molecular growth mechanisms
...nd size of these hairs, or trichomes, readily show when genes affecting actin filaments are askew and causing altered growth. The researchers previously had learned that a large protein complex, known as WAVE, activated ARP2/3, but they didn't know specifically which WAVE protein was the actual switch. T...Plants respond similarly to signals from friends, enemies
...actors, and then saw the similar changes occurring when plants were signaled by root-knot nematodes. In th...energy to survive. A similar relationship appeared when Weerasinghe studied the signals between plants and nematodes, even though the nematode provides no b...Research advances quest for HIV-1 vaccine
...detailed molecular structure of the complex formed when 4E10 binds to gp41 and determining how interaction...dous potential for accelerating HIV vaccine design when scientists from multidisciplinary laboratories come together to tackle a major scientific challenge....Male circumcision reduces risk of HIV transmission from women to men
...ural differences insexual behavior did not matter: when groups of men were excluded fromthe analysis based on ethnic or religious characteristics, thedifference in probability of infection related to circumcision statusdid not change.In addition to the results on circumcision, another significant resultof...Another Look Finds Promising Proteomics Test is Not Biologically Plausible
...present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimen......present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimen...Cracking the olfactory code in bees
...present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimen...Signaling protein builds bigger, better bones in mice
...present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimen...Scientists detect probable genetic cause of some Parkinson's disease cases
...h Parkinson's disease eachyear. The disease occurs when certain nerve cells die or becomeimpaired and can no longer produce dopamine, a brain signaling chemical(neurotransmitter). Without it, individuals can develop tremor ortrembling in hands, arms, legs, jaw, and face; rigidity or stiffness ofthe limbs ...Computers to be used to find blueprint for new influenza drug
...ns. The announcement of the grant comes at a time when fears are rising that an influenza outbreak develo...ls in our throats that the flu virus first attacks when a person becomes infected. The flu virus would be deceived into attacking the drug, called an inhibi...Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
...embryonic stemcells can differentiate into neurons when cultured under specificconditions. These same culture conditions, technically simple andefficient, were recently applied to primate embryonic stem cells andresulted in the generation of large numbers of DA neurons. In theircurrent JCI study, Jun Taka......Engineering Research Canada (NSERC). "In the past, when there have been episodes of major climate change or mass extinction, and species have moved out of their areas of origin into other areas, there have been emerging diseases. Parasites have moved into new areas and they've jumped ship into new hosts."...