Penn researchers link cell's protein recycling systems
...was prevented.” The accumulated misfolded proteins were cleared out by the lysosome system. “Then we knew that this system can compensate for the impaired proteasome function, which in itself tells us that the two pathways intersect,” says Taylor. “The question was, ‘How is this working"’” The Role of ...Bacteria ferry nanoparticles into cells for early diagnosis, treatment
... the journal Nature Nanotechnology. Experiments were carried out in cultures of human cancer cells, including intestinal, oral, liver, ovarian and breast cancer cells. The researchers also tested their method on live mice and showed how the technique could be used to deliver specific genes to various o...Herpes virus hijacks DNA repair process
...this activation occurred because repair mechanisms were mistaking replicating viral DNA for damaged or dysfunctional cellular DNA. "Viruses sometimes structure their own DNA differently than cellular DNA," Tarakanova notes. "Many of us thought that such differences might be triggering the DNA damage re...Study finds mix of disease processes at work in brains of most people with dementia
...al and psychological exams showed that, while they were alive, 50 of the 141 had dementia. Upon death, a n... for Alzheimer’s disease, although in life only 47 were clinically diagnosed with probable or possible Alzheimer’s disease. “We know that people can hav...Risk of stroke doubles if diagnosed with Type 2 diabetes
...bjects into a Type 2 diabetes cohort. All subjects were recently diagnosed with Type 2 diabetes and had a ...r five years of monitoring, stroke incidence rates were compared between the cohort and the general population. “What we found is that 9.1 per cent of th......es John Holladay and Heather Brown, all from PNNL, were able to coax HMF yields upward of 70 percent from glucose and nearly 90 percent from fructose while leaving only traces of acid impurities. To achieve this, they experimented with a novel non-acidic catalytic system containing metal chloride catalyst...454 sequencing identifies HIV drug resistance at early stage
...eatment from HIV infected individuals. The results were presented today at the XVI International HIV Drug ...sistant variants detected by Ultra Deep sequencing were found to be extremely important as it enabled the prediction of early antiretroviral treatment failu...Exploring the dark matter of the genome
...g fragments like transposons and single-copy genes were assembled by comparing numerous copies with unique...ly's total is 14,000 or more). Many of these genes were organized quite differently from genes in euchromatin, with much longer gaps (introns) between the c...In nature, proteins sweep up nanoparticles
...le. They found that the zinc sulfide nanoparticles were arranged in dense aggregates. Such tightly packed ...ide nanoparticles. Specifically, the nanoparticles were arranged like tree rings, and the proteins coated the particles’ surfaces and filled the gaps betwee...Cancer stem cells similar to normal stem cells can thwart anti-cancer agents
... stem cells. Both the cancer and normal stem cells were protected equally by multiple drug resistance transporters, even if the bulk of the tumor responded to chemotherapy. According to Dr. Donnenberg, the very fact that cancers can and do relapse after apparently successful therapy indicates the survi...Marine phytoplankton changes form to protect itself from different predators
... samples containing signals from the two predators were then separately introduced into Phaeocystis cultur...vival advantage. “We found that these organisms were making the right choice,” Hay said. “They were shifting to the shape that made them largely immune ......ars docked at a wharf in Cairns, three more swarms were found and the search widened. Already operating under marginal circumstances, many of Australia’s beekeepers can only afford a momentary sigh of relief. Asian bees (Apis cerana) are capable of carrying two types of Varroa mite – destructor and ...Research finds that circadian rhythms dominate all life functions
...ry that only 10 percent to 15 percent of all genes were affected by nature's clock. While scientists have long known that circadian rhythms regulate the behavior of the living, the study shows that daily rhythm dominates all life functions and particularly metabolism. The new study presents oscillation as...Potent possibilities for parasite attack
...out of more than 8000 genes present in each genome were found to be differentially distributed between the three species. This exceptionally small variation in gene content has given new insights into those processes that may determine disease severity in humans. "Identifying factors that allow three ...Gene responsible for common hearing loss identified for first time
...atio gave a very significant result, from which we were able to conclude that we were the first to identify a gene that influences the susceptibility for otosclerosis”, said Ms Thys. “...The kapok connection -- Study explains rainforest similarities
...can rainforests are similar because the continents were connected 96 million years ago. Research by University of Michigan evolutionary ecologist Christopher Dick and colleagues shows that kapok---and perhaps other rainforest--trees colonized Africa after the continents split when the trees' seeds travel...Clot-dissolving agent may be beneficial in treatment of severe frostbite
...tment of frostbite beginning in 2001. Patients who were admitted with severe frostbite underwent imaging s...ours of severe frostbite injury. These individuals were compared with 25 frostbite patients treated from 1995 to 2006 who did not receive tPA, plus one who ...Researchers demonstrate way to control tree height
...les can be overcome – a big “if.” The findings were recently published in the journal Landscape Plant ...tal pollution. In their studies, OSU scientists were able to create young poplar trees, which grow rapidly and can reach a mature height of 150 feet or m...Weizmann Institute scientists develop a general 'control switch' for protein activity
...s activity was reduced. Says Prof. Liscovitch: “We were surprised by the effectiveness of the method – it turns out that a small set of engineered proteins is needed to find the ones that respond to the drug. With their greater resources, biotechnology companies will be able to create much larger sets of ...Researchers discover 'acquired' DNA key to certain bacterial infection
...the National Academy of Sciences. Other co-authors were from the University of Nebraska. The key to the bacterium’s ability to enter environmental amoebas – and ultimately humans – is an “island” of genetic material acquired through evolution from another bacterium, according to Luiz E. Bermudez, a pro...