Simulations unravel outer membrane transport mechanism
...ions of various scenarios to test which hypotheses were most feasible. Their work relied on detailed cryst...hydrogen bonds between TonB and the luminal domain were strong enough to remain intact while TonB pulled the end of the luminal domain away from the barrel.......ld no longer get out of the cell. However, if they were replaced with synthetic membrane anchors and clumping domains Gag regained its ability to get out of cells in exosomes. Gould speculates that cells may have initially developed exosomes as a quality control mechanism to get rid of clumped protein...New study reports hotel guests at risk from carbon monoxide poisoning
...ts, 41 employees or owners and 20 rescue personnel were accidentally poisoned. Of those poisoned, 27 died, 66 developed pathological conditions, and 6 had conditions resulting in a jury verdict. Jury verdicts have averaged $4.8 million per incident (range=$1 million-17.5 million). Poisoning occurred at ho...Snoring in children might be an allergic type disease
...onology has established children with rhinitis who were first born, were exposed to maternal tobacco smoke during the first year of life and/or who had asthma and/or eczema ...CSIRO scientists join fight to save 'Tassie devil'
... tumour tissue and tumours grown in the laboratory were examined. A recent Senior Scientist’s Scientific Forum on the DFTD reviewed progress in understanding and managing the disease and set an agenda for future research and management. “The aim is to stop the disease in it tracks and we want to b...The insect vector always bites twice
...sinia species, uninfected, vectors or non-vectors, were separated then put into contact with the serum of individual subjects, infected or uninfected, exposed to bites. Comparison of salivary protein immunogenic profiles obtained showed that they differ depending on the infection status of the subjects (e...A new plant-bacterial symbiotic mechanism promising for crop applications
...s rather special form of symbiosis. These bacteria were found to have no nod genes, usually essential for nodulation. Bradyrhizobium consequently appeared to use mechanisms that involved other genes. This surprising result calls into question the universally recognized model of molecular communication tha...Hormone helps mice 'hibernate,' survive starvation
...ce, the animals’ metabolism changed. “When mice were given this hormone, their metabolism appeared as if they were starved, even after they had just eaten,” said Dr. Kliewer. Because limiting food consumption is ...Bigger horns equal better genes
...bex, and we found that it can." The researchers were particularly intrigued about the ibex's horns beca... in the Alps mountain range in Europe, alpine ibex were hunted almost to extinction about a century ago for sport and the purported pharmacological properti...How to lose weight and not go hungry: HU researcher develops drug that mimics feeling of 'fullness'
...alog to the naturally occurring aMSH hormone. They were able to demonstrate that their peptide, which they...han the average for mice of their size and age who were not being given the compound. The peptide has been patented in Europe and the U.S., and a commer...Envisat captures first image of Sargassum from space
...r Chuamin Hu of the US University of South Florida were able to identify extensive lines of floating Sargassum in the western Gulf of Mexico in the summer of 2005. "This appears to be the first report of a satellite image of Sargassum," Gower said. "It is usually associated with the area of the North Atl...Largest synthetic gene ever built offers insights into anti-malarial drug resistance
...nchona tree, and leaves from the artemisinin shrub were the only options available to treat the infection until World War II, when both Germany and the United States started massive drug discovery programs based on the toll the parasite was having on soldiers − more U.S. soldiers died from malaria in th...Loss of stem cells correlates with premature aging in animal study
...0 to 20 percent of cells that escaped ATR deletion were able to reconstitute tissues in the engineered mice, at least initially. “Think of aging as a slow loss of stem cells, a deterioration of pools of cells that reside in each tissue type,” says Brown. We accelerated the aging process by wiping out...Caribbean frogs started with a single, ancient voyage on a raft from South America
... a professor emeritus of the University of Kansas, were involved in much of the field work. A third co-au...cross land bridges that existed when those islands were connected in a geologic arc about 70-to-80-million years ago. A second major theory proposed that t...New bacterium discovered -- related to cause of trench fever
...uch easier. Also collaborating on the research were scientists at the Massachusetts General Hospital o... General Hospital Medical Center. “The bacteria were eating away a bone in the arm of an AIDS patient – for months,” Koehler recalls. “They can cause ext...In mice, drug protects against diabetes and atherosclerosis
...oratory mice that had been fed unhealthy diets and were genetically predisposed to these common killers, a...id-binding proteins, aP2 and mal1. When these mice were fed a high-cholesterol or high-fat diet, the expected signs of metabolic diseases such as atheroscle...Columbine flowers develop long nectar spurs in response to pollinators
...ir nectar, biologists have found. The researchers were Justen Whittall of the University of California at...he University of California at Santa Barbara. They were funded by the National Science Foundation (NSF). Their results appear in this week's issue of the jo...Longer treatment benefits sleep apnea patients
...tinely used CPAP each night. In addition, patients were evaluated for daytime symptoms such as excessive d... functional status or quality-of-life improvements were maximized after 7.5 hours of use each night. Although individual patient response to CPAP therapy ca...Ancient DNA traces the woolly mammoth's disappearance
...r killing off the small, terminal populations that were left.” Barnes, along with Dr. Adrian Lister of the University College London and the Natural History Museum in London and others, had earlier found evidence that bison, bears, and lions underwent major population shifts twenty-five to fifty thousa......cal cord transplants. While all bone marrow donors were matched, nearly all cord blood donors were mismatched. The main objective of the research was to compare the results after cord blood and ma...