New research to cut animal testing
...ssessment in the short term as you can't ask human volunteers to take novel drugs straight from testing done in tube tests," said Dr Walmsley. "But if we can refine the pre-animal tests and increase people's confidence in them, then we will be able to reduce the number of chemicals that are tested on live ani...Antioxidant protects against lung damage in silicosis
... obstructive pulmonary disease and 27 healthy male volunteers as controls. The investigators also studied a mouse model of silicosis. Silicosis results from exposure to crystalline silica in mines and foundries, at sand blasting operations and at stone, clay, and glass manufacturing plants. Crystalline silic...Pleasure and pain: Study shows brain's 'pleasure chemical' is involved in response to pain too
...find the exact areas of dopamine activity. The volunteers answered questions from two standardized questionn... nor of drug addiction or dependence. The 7 female volunteers were not taking birth control pills and were scanned at the same point in their menstrual cycles. ...Brains can recover from alcoholic damage but patients should stop drinking as soon as possible
...n 10 cigarettes a day), were excluded. Ten healthy volunteers (six men, four women), matched for age and gender, were recruited as controls for the study. The data were analysed and evaluated using FSL, a sophisticated software package developed at the Oxford FMRIB Centre, and LCModel (a computer program that a...Researchers examine why food tastes bad to chemotherapy recipients
...ich explained. Some tests will be done with human volunteers to determine reactions of volatile compounds in the mouth. Since saliva contains proteins and enzymes, it may have some effect in enhancing the metallic flavor. They will also use in-vitro experiments in order to conduct experiments at higher concen...Ecstasy can harm the brains of first-time users
...e users. Dr. de Win and colleagues examined 188 volunteers with no history of ecstasy use but at high-risk for first-time ecstasy use in the near future. The examinations included neuroimaging techniques to measure the integrity of cells and blood flow in different areas of the brain and various psychologica...Why Popeye only has eyes for spinach
...low the degenerative process. This latest study on volunteers with early-stage AMD will test that idea." Scientists do not yet understand why some people are susceptible to age-related macular degeneration but warn the incidence is likely to rise as the population ages. In collaboration with Tinsley Ophthal...Bird flu vaccine additive may stretch supply
...roups with and half without the MF59 adjuvant. The volunteers were tested for antibodies at 28 days and 56 days. "Antibody in the blood to the influenza virus that you're trying to protect against is what protects people from getting the flu," said Robert Atmar, MD, lead author of the study. "What vaccines d...'Mindless autopilot' drives people to underestimate food decisions
...ay, the average response was 15. However, when the volunteers then answered specific questions about when, what, how much and where they ate and who made decisions about meals, snacks and beverages, the researchers found that the staffers and students actually made an average of 221 food-related decisions each ...A reason why video games are hard to give up
...players' motivation in virtual environments. Study volunteers answered pre- and post-game questionnaires that were applied from a psychological measure based on Self-Determination Theory, a widely researched theory of motivation developed at the University of Rochester. Rather than dissect the actual games...H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses
...r. Atmar and his colleagues tested the vaccines in volunteers aged 18 to 34 in this Phase I clinical trial. Phas...lly occurring virus. The researchers vaccinated 48 volunteers with non-adjuvanted H9N2 vaccine (made from inactivated virus) at one of four dosages--3.75, 7.5, 15...Epstein-Barr virus might kick-start multiple sclerosis
... T cells from 20 untreated patients with MS and 20 volunteers who had been infected by Epstein-Barr virus but di...ontrols. As expected, the T cells in the healthy volunteers activated only in the presence of a specific group of peptides. But, Edwards said, "EBNA1-specific T...The brain's motivation station
...ormation. In their studies, the researchers asked volunteers to participate in two types of reward-related tasks as they scanned the subjects' brains using functional magnetic resonance imaging. In this technique, harmless magnetic fields and radio waves are used to detect regions of higher blood flow in the b...Study identifies substances in grapefruit juice that interact dangerously with some drugs
...atkins said. In this randomized study, 18 healthy volunteers took 10 milligrams of felodipine with each of three juices: orange juice, regular grapefruit juice, and grapefruit juice devoid of furanocoumarins. Blood was collected over 24 hours to measure felodipine blood levels. One week elapsed between each fe...Researcher studies, treats military with 'silent disease'
...ximity to Walter Reed. Thirty percent of the study volunteers had minimal liver disease, Sjogren said. Of the 70...take," she said. On initial questionnaires, study volunteers reported that they were depressed; anxious about their health, families, and careers; and having tro...Lost in thought: Brain research
...ddressing this question ?by scanning the brains of volunteers performing various mental tasks. The results of their study, which were published recently in the journal Neuron, were unanticipated: When subjects were given outwardly-focused tasks that demanded their full attention, areas of the brain that relate ...Combating anthrax: Results of study published this month as researchers look for a better vaccine
... first human testing, the vaccine was given to 100 volunteers at four sites around the United States, said Geoffrey Gorse, M.D., a Saint Louis University researcher who was the main author of the paper. "This type of research, five years after 9/11, continues to be very important to pursue," Gorse said. "We ne...Production of key Alzheimer's protein monitored for first time in humans
... nervous system to remain constant. In the healthy volunteers who were the first test subjects, Bateman found the production and clearance rates were the same. He is now applying the technique to individuals with Alzheimer's disease. Researchers are developing Alzheimer's drugs that either decrease Abeta prod...Cell phone emissions excite the brain cortex
...eloped a double-blind study in which 15 young male volunteers were exposed to EMF signals from a GSM 900 cell phone for 45 minutes. They measured Motor Evoked Potentials (MEPs) during motor cortex TMS before, and immediately after EMF exposure, and also one hour later. In 12 of the 15 subjects, the data showe...Chocolate, wine, spicy foods may be OK for heartburn, Stanford study finds
...rn. "It probably wouldn't be that hard to recruit volunteers for a study of chocolate," Gerson noted. "People like to eat chocolate." ...