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Tag: "vivo" at biology news

New method shows it is possible to grow bone for grafts within a patient's body

...ue engineering, is described in a paper titled "In vivo engineering of organs: The bone bioreactor" publis...ind that this zone, which they have dubbed the "in vivo bioreactor," filled healthy bone in about six weeks. And it did so without having to coax the bone t...

Critical step traced in anthrax infection

...e tried to bridge reductionist science with the in vivo situation ?we have to do both to make correlations," he said. The researchers, who were funded by the National Institutes of Health and the National Science Foundation, will continue to study protein unfolding in translocation during anthrax infecti...

Human Eggs Can Develop From Ovarian Surface Cells In Vitro

...embryo. These in vitro findings support earlier in vivo studies by Bukovsky and colleagues that OSE cells are bipotent; capable of differentiating along two developmental pathways and becoming either egg or granulosa cells. The authors speculate that this bipotent differentiation may represent a sophistic...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...stance to the antibiotics in vitro. The effect in vivo was dramatic. Blocking LexA in rodent models of E. coli infections halted the growth of antibiotic resistance. Three days after being subjected to antibiotics, the rodents showed no level of resistance to rifampicin or ciprofloxin, when they harbored...

Affymetrix Launches New Globin-Reduction Kits and Protocol Developed with PreAnalytiX

...cellular RNA profiles. "An accurate picture of in vivo gene expression profiles is essential for understanding gene regulation as it relates to different disease states and a patient's response to drug therapy," said Noel Doheny, Vice President of PreAnalytiX and QIAGEN. "We continue to see a strong mark...

Scientists discover how Ebola virus infects cells

... of existing knowledge regarding the design and in vivo pharmacology of these inhibitors may facilitate development of an anti-Ebola-virus therapy." Reference: K Chandran et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science Express. Published online April 14, 2...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...the researchers have validated their hypothesis in vivo using mice that do not produce eNOS. These mutant mice had a marked reduction in iNOS production in response to bacterial endotoxin, as well as lower plasma levels of NO2- and NO3- and less mortality than normal mice. The scientists also showed that ...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...the first demonstration of therapeutic efficacy in vivo of RNA interference-mediated gene silencing in an ALS model," notes Raoul. Because the normal form of the SOD1 protein may be necessary for the survival or function of adult human motor neurons, the Swiss researchers designed a gene replacement tech...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

...ously. Emissive polymersomes perform much like in vivo imaging systems that use semiconductor-based "quantum dots." These quantum dots, however, are hard matter, which could collect within the circulatory system, potentially causing a stroke. According to the Penn researchers, brightly emissive polymerso...

Gene therapy for Parkinson's disease moves forward in animals

...n be a promising approach to this disease using in vivo gene therapy, which is very applicable to humans. It even presents theoretical reasons that might solve some of the safety issues that have been raised about GDNF. But many things remain that we still don't understand." The recent findings in labora...

The very unexpected life and death of a leukemic cell

...th Shore-LIJ analyzed the kinetics of CLL cells in vivo by employing a non-radioactive labeling technique ...ysicians to predict disease progression. ### In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells View...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...n be a promising approach to this disease using in vivo gene therapy, which is very applicable to humans. It even presents theoretical reasons that might solve some of the safety issues that have been raised about GDNF. But many things remain that we still don't understand.?/p> The recent findings in ...

Source of molecular triggers in cutaneous T cell lymphoma identified

...oratory system mimicking the tight relationship in vivo between CTCL cells and LC. The research team considered three broad categories of antigen as the source of the signal: the protein products of tumor viruses, of mutated genes, and of normal but usually inactive genes. The study reports that CTCL dev...

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