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Tag: "vivo" at biology news

A first -- Hebrew University scientist observes brain cell development in 'real time'

...versity of Jerusalem has succeeded in observing in vivo the generation of neurons in the brain of a mammal. Dr. Adi Mizrahi of the Department of Neurobiology at the Alexander Silberman Institute of Life Sciences at the Hebrew University, used mouse models to study how neurons, or nerve cells, develop fr...

LIAI scientists make important finding on cytomegalovirus transmission

... and two ways in which we can modulate immunity in vivo with the desired result of blocking virus spread to uninfected individuals. "The potential excitement in the findings is that we may be able to one day use this kind of treatment in humans to block or significantly reduce the spread of cytomegalov...

DNA-damage test could aid drug development

...esses, in vitro human models could be closer to in vivo human than in vivo mouse," notes Shuga. "That premise will be tested in coming years as new systems become available." ...

Growing nerve cells in 3-D dramatically affects gene expression

... suspect that hothouse cells do not behave like in vivo varieties. This means that the critical functions scientists are trying to understand by studying these cells ?from the proliferation of cancer to the bacterial assault by antibiotics ?may play out differently. Studies indeed show differences in beha...

Researchers wake up viruses inside tumors to image and then destroy cancers

... The technique is the first in the new field of in vivo molecular-genetic imaging that doesn't require transfecting tumors with a "reporter" gene, the scientists say. "The beauty of this is that you don't have to introduce any reporter genes into the tumor because they are already there," says radiolog...

Study shows isolation of stem cells may lead to a treatment for hearing loss

... loss. This line of research will evaluate the in vivo survival and differentiation of self-renewing cochlear cell populations and potentially lead to new therapies for the numerous individuals that are going to suffer from noise-induced hearing loss in the near future. ...

Cancer-killing invention also harvests stem cells

... a series of lab experiments, both in vitro and in vivo using rats, with this selectin-coated tube to filter the bloodstream for stem cells. It worked, and the King Lab discovered that they could attract a large number of cells to the wall of their selectin-coated device, and that 38% of these captured c...

Bioluminescence at the service of a novel cerebral imaging technique

...boration have developed a new technique for the in vivo imaging of neuronal function using bioluminescence, based on a GFP-aequorin fusion protein. This imaging technique enables the monitoring of neuronal activity (and more specifically, calcium activity), real-time and in-vivo, in either a small group o...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...that Nutlin-3a has striking anti-tumor activity in vivo in a mouse xenograft model for the PEL. Nutlin-3a treatment resulted in a marked regression of all tumors in the treated animals in two weeks. These results demonstrate that p53 reactivation via Nutlin-3a is an efficient treatment for KSHV-lymphomas ...

No carrier necessary: This drug delivers itself

...ystals that they continue to pursue. Further in vivo studies with HPPH nanocrystals are being conducted by scientists at UB and RPCI, including Pandey and Allan R. Oseroff, M.D., Ph.D., chair of the department of dermatology at RPCI and in UB’s School of Medicine and Biomedical Sciences. The UB/RPCI...

Xie Lab demonstrates the role of microRNA pathway

...entially be used to control stem cell functions in vivo and stem cell expansion in vitro." "We are in the process of identifying the microRNAs that are important for stem cell self-renewal," said Dr. Xie. "Understanding the mechanisms controlling stem cell self-renewal will be crucial to our developing...

Small molecule dervived from Rb2/p130 could act as cancer therapeutic

...emonstrated the ability to inhibit tumor growth in vivo and could be developed into an anti-cancer therapeutic, according to researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine. The researchers reported their findings, "A small molecule based on the pRb2/p130 sp...

Blocking immune cell action increases Alzheimer's-associated protein deposits

...ed early online release. "Our results provide in vivo evidence that the brain's immune system plays a protective role in early Alzheimer's disease by mediating the clearance of amyloid-beta," says Joseph El Khoury, MD, of the MGH Center for Immunology and Inflammatory Diseases, the paper's lead author. ...

How T lymphocytes attack

...n microscopy to demonstrate, for the first time in vivo and real-time, how T lymphocytes infiltrate a solid tumour in order to fight it. These "defenders" methodically encircle the enemy positions and "patrol" until they meet a tumour cell, which they have previously learnt to recognise. They then halt ...

Widely used iron nanoparticles exhibit toxic effects on neuronal cells

...tic force. Eventually they had hoped to conduct in vivo experiments, using nanoparticles-laden nerve cells to bridge regions of damaged neurons. However, when they added nerve growth factor to nanoparticle-laden cells in culture flasks, they observed toxic dose-dependent effects: some cells died, and many...

New imaging technique tracks traffic patterns of white blood cells

...r intravital observations of leukocyte behavior in vivo by allowing the near-simultaneous observation of c...es will greatly aid investigations to elucidate in vivo imflammatory cell behavior, and provide a powerful tool for the development of therapeutics for thes...

Math model predicts cancer behavior

... said. Next up for the group are in vitro and in vivo experiments designed to test, validate and refine the mathematical model. ...

Discovery in the evolution of the immune system absorbing cells

...ians are capable of strong phagocytosis both in in vivo and in vitro experiments. The work has been published in Nature Immunology, the most prestigious journal worldwide in the field of immunology. According to Dr Sunyer, "this is important so that we can understand not only how the immune systems of f...

Researchers create mouse lacking key inflammation gene

...gical conditions. Researchers are offering this in vivo model for sale to spearhead discovery of drugs against inflammatory disorders such as arthritis and Crohn's disease. In the study, Boston University researchers created a mouse lacking the gene that encodes for the LITAF protein. They found that s...

'Conversation stoppers' fight deadly bacterial infections

... of an alternative pathway for NAE biosynthesis in vivo and demonstrate that these new routes are especial...-mediated route makes to the production of NAEs in vivo is yet to be determined and will require "the generation of genetic or pharmacological tools that se...

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