viral 2 7

Tag: "viral" at biology news

Drug resistant avian influenza viruses more common in Southeast Asia than North America

...bits the function of the M2 protein and thus stops viral replication. "By analyzing the sequence of the transmembrane part of the M2 gene we were able to determine how frequently amantadine resistance occurs in avian influenza A subtypes isolated in various parts of the world-especially among those subty...

Confronting Influenza: Are We Prepared?

...topics will include the structure of the influenza viral proteins and the relevance of that structure for drug development, lessons learned from the 1918 pandemic, current H5N1 (Avian influenza) developments in Asia, the state of U.S. preparedness and influenza surveillance, and the private sector's views ...

UF scientist finds unexpected link between cat and human AIDS viruses

...esearch? The viruses HIV and FIV are from the same viral family," Yamamoto said. "For that reason, the amino acids that make up the proteins in both viruses share some common regions. There appear to be regions of HIV, or variations of the core protein we used in our studies, that may provide protection in...

Hepatitis C complicated by morphine withdrawal

...events that occur in liver cells and expression of viral RNA and proteins that HCV uses. Although the repl...nse mechanism utilized by liver cells to fight off viral infection, including HIV, this study suggests that morphine withdrawal weakens host cell immunity an...

'License to kill' enables powerful immune attack cells in mice

...struggling to understand such issues as persistent viral infections and patients' responses to bone marrow transplants. The findings will appear in the August 4 issue of Nature. The immune cells in question already evoked cinematic connections simply by virtue of one of their names: scientists commonly re...

On a wing and a prayer - Alaska researchers seek clues to bird flu

...Wild birds are the natural hosts of many influenza viral strains that normally do not infect humans. Howeve...nomic Research (TIGR) for sequencing of the entire viral RNA genome which will then be published in GenBank, the National Institutes of Health collection of ...

Preventing a pandemic: Study suggests strategies for containing a flu outbreak

...he effectiveness of TAP and GTAP. For even higher viral reproductive numbers, household quarantines would also be necessary to contain the virus. A combination of TAP, prevaccination and quarantine could contain strains with a reproductive number around 2.4. A value of 2.4 is relatively contagious, though...

HIV inserts into human genome using a DNA-associated protein

...are sites that lead to efficient expression of the viral genome. Most HIV-infected cells in a patient will ... the sun is shining, as it were, producing lots of viral copies during a short time, so that the virus can maximize production of daughter virions," says Fre...

Scientists characterize proteome of human cornea

...ffect the cornea range from bacterial, fungal, and viral infections (keratitis) and allergies to various dystrophies including keratoconus. "Corneal damage and disorders account for several million cases of impaired vision and are second to cataracts as the most important cause of blindness in the world,"...

Zinc supplements safe for HIV-infected children

...isease progression in children by increasing their viral load. Zinc supplementation is known to decrease th...he study authors found no increase in plasma HIV-1 viral load measurements in the children receiving zinc, meaning that zinc supplementation is safe for HIV-...

New vaccine platform may fight infections with causes from influenza to bioterrorism

...ur vaccine platform may be effective in preventing viral illnesses such as influenza, in high-risk, immune-deficient individuals," Dr. Kolls said. "This new technology opens up the possibility that therapeutic vaccine response can be achieved in populations of patients who face the greatest risk ?children,...

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

...to B-cell lymphomas. Now, they have found that the viral protein--called EBNA3C (for EBV nuclear antigen)--mediates the degradation of the retinoblastoma protein, an important molecular brake for cell proliferation. Erle S. Robertson, PhD, an Associate Professor of Microbiology who leads the Tumor Virolog...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...rmal hemoglobin that causes sickle cell disease, a viral vector was introduced in cell cultures of patients who have the disease. The vector carried a therapeutic globin gene harboring an embedded small interfering RNA precursor designed to suppress abnormal hemoglobin formation. Tested in adult stem cell...

Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds

...cer and an immune reaction, that have turned up in viral gene therapy trials. Instead this approach uses naked DNA that travels through the bloodstream to cells of the body. For his part, Rando said that no matter how well gene therapy works in an isolated muscle, researchers still must figure out how to ...

A new step towards an AIDS vaccine

...eractions mediate the endocytosis of HIV-1. Next, viral nucleic acids, particularly RNA, stimulate pDCs th...c infections due to HIV-1 and correlates with high viral load, reduced CD4 counts and susceptibility to opportunistic infections, and is only partially rever...

Polymer gel can block toxic leakage problem in gene therapy

...oduce glowing proteins in order to trace where the viral particles went during 24 hours after being injecte...hat investigation showed that 10 times more of the viral particles were transported to other organs than were retained within the tumors. And most of the err...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

... using a synthetic system to deliver genes because viral vectors aren't reliable." More than one-half of cancers have mutations in the p53 gene, which has been called the "guardian of the genome" because of its ability to get rid of genetically damaged cells. The researchers thought that getting a workin...

Scientists observe how a close bond activates the immune system

...a demanding job. "Just 10 dendritic cells can show viral antigens to over a million T cells in a day," says Dr. Dustin. Once a T cell's antigen receptor finds an antigen match, the T cell forms an immunological synapse with a dendritic cell through which it queries the dendritic cell for additional infor...

New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus

...ted a live virus with all eight of the Spanish flu viral genes. The genome sequence information was recover...cs," which involves transferring gene sequences of viral RNA into bacteria and then inserting combinations of the genes -- often after manipulating them -- i...

First big influenza genome study reveals flu evolution

...marks first author Elodie Ghedin, who heads TIGR's viral genomics lab. "This is perhaps the most detailed s...tic change. To do so, TIGR has built an innovative viral genomics lab, which is ramping up to sequence 100 influenza genomes weekly. Influenza poses a majo...

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