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Tag: "viral" at biology news

Chimp genome reveals a retroviral invasion

... a nonreproductive cell, infection may spread, but viral DNA will die with the host. A retrovirus is called...acaque) species. The authors compared the sites of viral integration in each of these primates and found that few if any of these insertion sites were shared...

UCLA study assesses cost-effectiveness of Hepatitis B drugs

...erapy with lamivudine, but changing to adefovir if viral resistance is encountered. Investigators found th...erved as a second-line agent in people who develop viral resistance for lamivudine ?a therapy that has been available for over 15 years. The study notes tha...

Virologists make major step towards understanding the process of HIV infection

...found an area within the structure molecule of the viral capsid that tolerates the substantial extension by GFP. Although the insertion of the GFP molecule enlarges the HIV structure protein by about one half, infectious viruses continue to be generated. Using electron microscopy, Zentgraf’s team was able ...

New Species of Coral Discovered Off Southern California

...found an area within the structure molecule of the viral capsid that tolerates the substantial extension by GFP. Although the insertion of the GFP molecule enlarges the HIV structure protein by about one half, infectious viruses continue to be generated. Using electron microscopy, Zentgraf’s team was able ...

Asymptomatic HIV babies could use earlier treatment

...possible toxic side-effects and the development of viral resistance to available treatments must be balanced against a desire to do everything possible to keep infected children healthy. Maldonado and her colleagues collected data from hospitals throughout northern California over a 17- year period. Stati...

High fidelity keeps human DNA assembly line humming

...control. It's important for understanding cancers, viral infections and normal human development," said Zac..."If you want to understand and control things like viral infections and tumors this fundamental process has to be understood in every detail. This is basic s...

Gene silencing technique offers new strategy for treating, curing disease

...at the level of malfunctioning gene expression, or viral or bacterial gene expression," said Dr. David Corey, professor of pharmacology and biochemistry. "This is an approach that could theoretically produce a drug for the treatment or cure of almost any disease." In two papers appearing in the online edi...

U of T researchers map role of Epstein-Barr virus in cancer

... have mapped the molecular details that show how a viral protein coded in the Epstein-Barr virus immortalizes cells and causes them to continuously grow, thereby predisposing people to certain types of cancer. "Epstein-Barr virus (EBV) is one of the most common human viruses in the world and is strongly l...

Cancer drug slows poxvirus in mice

...o provides new support for the concept of treating viral infections by targeting specific host cell molecules rather than the viruses themselves," says NIAID Director Anthony S. Fauci, M.D. The senior author of the paper, published online this week in the journal Nature Medicine, is Daniel Kalman, Ph.D., ...

FDA Approves New Treatment for Chronic Hepatitis B

...ression of chronic hepatitis B by interfering with viral reproduction. FDA based its approval of Baraclude on the results of three studies in which Baraclude was compared to another anti-viral drug, lamivudine. In all three clinical studies, patients treated with Baraclude showed significant improvement ...

Random gene expression may drive HIV into hiding

... in the 1990s, showing that random fluctuations in viral gene expression can influence latency in a bacteri...cientists infected cultured human cells with their viral vector, they found that cells that initially expressed a low level of virus were very unstable: Afte...

Newest HIV drugs should be used with FUZEON(R)

...stance their best chance of achieving undetectable viral load ?the optimal treatment goal for all people living with HIV. "Undetectable viral load should be the ultimate treatment goal for all triple-class experienced patients. FUZEON combine...

Using nanoparticles, in vivo gene therapy activates brain stem cells

... an efficiency that is similar to, or better than, viral vectors and with no observable toxic effect, accor...ral technique has proven to be as effective as the viral vectors in vivo," said co-author Paras N. Prasad, Ph.D., executive director of the UB Institute for ...

Brown-Harvard team solves mobile DNA's surgical sleight-of-hand

...ith dyes that allowed her to draw up a map of this viral DNA during insertion. "It was gratifying to see that two totally different experimental approaches give the same picture," Radman-Livaja said. "It means we have a very solid foundation for the next step forward in understanding this fascinating proc...

Enlisting genomics to understand flu evolution

...elp scientists make better predictions about which viral strains will attack during upcoming flu seasons an...tributed its hemagglutinin gene (a highly variable viral protein that must be recognized by the host's immune defense system) to a virus common during the pr...

Achilles heel of the herpes virus possibly found

...eam. The Italian team has identified a region of a viral surface protein that matches the U-M team's predic...5 receptor. "It appears that B5 is a new class of viral receptor. Unlike other viruses so far, HSV seems to have evolved to take advantage of a broadly pres...

New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids

...une diseases may be associated with a bacterial or viral infection that stimulates production of antibodies and immune cells called T cells, which are targeted against bacterial proteins that closely resemble "self" proteins, leading to crossreactivity with healthy tissues. Dr. Gennaro De Libero from Unive...

New tool reveals secrets of migrating cells

...s and killer, or CD8, cells primed for combat with viral invaders. "We were surprised by how rapidly and directly the cells move to their final destination." The technique could allow researchers in many fields of biology to track migrating cells, which biologists have discovered are common in many types ...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

..."We found that one dose of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal said. "If the HO-1 pathway is blocked, the protective effects of IL-10 are lost. The delay in vascular disease shown in this study could ?after more research and possible clinical trials in ...

Harmless virus may hold key to more effective HIV drug discovery

..., more flexible compounds could better accommodate viral mutations. The research is part of a UCI program aimed at expanding the anti-HIV drug arsenal. The program includes National Academy of Sciences member Larry Overman in the Department of Chemistry, who together with co-workers synthesized the small...

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