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Tag: "viral" at biology news

UCLA scientists transform HIV into cancer-seeking missile

...he scientists used a version of HIV from which the viral pieces that cause AIDS had been removed. This allo...t UCLA. Second, the scientists stripped off HIV's viral coat and redressed it in the outer suit of the Sindbis virus, which normally infects insects and bir...

How an AIDS-Related Cancer Unleashes Inflammation

...vered one way that Kaposi's sarcoma ?a cancer-like viral disease traditionally associated with AIDS ?trigge...ne production? "While there are many genes in the viral genome that are capable of inducing cytokine production, the mechanism underlying this induction has...

Antibiotic might fight HIV-induced neurological problems

...Antiretroviral drugs target and interfere with the viral proteins needed to accomplish this. In contrast, minocycline doesn't target the virus or its proteins. While they're still working out the details, the researchers have shown that minocycline "calms down" as yet undefined biological pathways that in...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

... neurodegenerative diseases. For example, prenatal viral infection has been implicated in schizophrenia, autism and cerebral palsy; bacterial infection is a risk factor for Parkinson's disease. Up to 20 percent of pregnancies have complications involving infections of the uterus and its contents, a number ...

Asthma gene clusters identified

...xacerbated by different factors, such as exercise, viral infection or allergic triggers. In doing so, physicians will be in a better position to assess and treat a patient's asthma with greater precision. "As we learn more about disease and how patients respond to treatment, we will eventually be able to ...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

...ture Biotechnology. The researchers harnessed the viral trait for attacking and commandeering cells, and t...te cells" -- while at the same time conserving the viral component for targeting and destroying tumors. Mass production of a retargeted virus was not possibl...

Yale researchers identify molecule for detecting parasitic infection in humans

...tance. Most infections are caused by bacterial or viral microorganisms that produce molecules quite differ... prominent in the United States than bacterial and viral infections, the global impact of parasitic infections on health is tremendous. "Insight obtained fro...

NYU study reveals how brain's immune system fights viral encephalitis

...w the innate immune system in mice's brains fights viral infection of neurons. The findings, published as t...at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brain. "Th...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

... off viruses and other pathogens. Interferons stem viral infection by inhibiting cell division in neighboring cells—thus preventing the virus from reproducing—and triggering pathways that kill the infected cells. It's thought that interferon therapy may relieve symptoms associated with MS by correcting imb...

Norovirus, AIDS vaccine and Hepatitis Virus

..., frequently results from exposure to bacterial or viral pathogens. Noroviruses (NoV's) are considered to b...sed alone, without the need for booster doses with viral proteins, for large-scale immunization programs," say the researchers. (D.K. Singh, Z. Liu, D. Shef...

Epstein-Barr virus protein crucial to its role in blood cancers

...arr virus, the investigators found that a specific viral protein targets a molecule that normally regulates...ocess, of resting B cells. In the presence of this viral protein ?called EBNA3C (for EBV nuclear antigen) ?the cell cycle of the usually quiescent human B ce...

Defensins neutralize anthrax toxin

...arr virus, the investigators found that a specific viral protein targets a molecule that normally regulates...ocess, of resting B cells. In the presence of this viral protein ?called EBNA3C (for EBV nuclear antigen) ?the cell cycle of the usually quiescent human B ce...

HIV vaccine trial breaks ground for future research

...ho became infected during the study, pre-treatment viral loads were similar in the placebo and vaccine groups over their follow-up visits. During analysis of various subgroups of the study population, a higher, though statistically insignificant, vaccine efficacy was found in the high-risk and the non-whi...

Viral protein influences key cell-signaling pathway

...p300 show-up among the many genes affected by this viral protein." HTLV-1 infects an estimated 15 to 20 mi...timulate their proliferation and promote efficient viral infection. ...

Stopping smallpox in its tracks: A new anti-viral approach

...nitiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and spread. The authors show that treatment with these erbB-1 inhibitors are effective i...

Gene Therapy Cures Inherited Liver Disease In Rats

...us to carry the gene into the animal's cells. This viral vector, as it is called, was manipulated so that i...f the lack of genes in this area of the cell. The viral vector itself is important because it has no long term effect. It does not become part of the geneti...

Multi-purpose protein regulates new protein synthesis and immune cell development

...rotein response is activated in many diseases from viral infections to stroke to Alzheimer's disease," says Kezhong Zhang, Ph.D., a senior research associate in biological chemistry and first author of the paper. "All these things disrupt protein folding and put stress on the cell. By doing so, they activa...

Marburg haemorrhagic fever in Angola update

... from extensive experience with outbreaks of other viral haemorrhagic fevers, including Ebola, outbreaks of Marburg can be brought to an end using classic public health interventions. In theory, the measures needed to end the Angolan outbreak are few in number and straightforward in nature. Rapid detection...

Buying Time Through Hibernation on Demand

...crucial time it takes to diagnose the bacterial or viral cause and administer the proper antibiotic. "Here's a patient group, quite commonly found in emergency rooms around the country, who would do well if they could just have their core body temperature taken down in order to buy them time until the pat...

Anti cancer virotherapy well tolerated in first human administration, research finds

...inflammation" as a result of the injections of the viral material and basic blood chemistry and liver enzym... the introduction into the body of the appropriate viral material which then reproduces at a rapid rate over a short period of time, devouring the cancer cel...

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