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Tag: "viral" at biology news

Chemists create 'Superbowl' molecule; May lead to better health

...ery, chemical synthesis and as models for cell and viral behavior. Until now, these molecules have had a very limited carrying capacity. "The compounds we made are bigger versions of these original bowl molecules," says study leader Michael Sherburn, Ph.D., a chemist with Australian National University in...

Viral DNA sequence a possible trigger for breast cancer

...f to transform cells single-handedly suggests that viral infection may be an important and previously unrec... has largely been attributed to the integration of viral DNA into locations that trigger the expression of host cancer-causing genes. An intriguing wrinkle t...

New binding target for oncogenic viral protein

...gen protects cellular Fbw7 targets that facilitate viral replication and tumorigenesis. "I think this work underlines the importance of Fbw7 as an emerging tumor suppressor and the consequences of its loss in tumors," Dr. Welcker emphasized. "The study of DNA tumors viruses has been an extremely importan...

Fox Chase Cancer Center scientists identify immune-system mutation

...s gland, are essential for combating intracellular viral and bacterial infections (cell-mediated immunity) and also for helping other white blood cells (B cells, derived from bone marrow) generate antibodies against foreign agents that enter the body. Other T cells are known as killer cells because they at...

Scientists Replicate Hepatitis C Virus in Laboratory

...co-author of the study. “Our model system produced viral particles that have all the properties of the whol...idence together with an analysis of the replicated viral RNA supports a conclusion of viral replication and production.?/p> The NIDDK group used a strain...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...ldren under age 5 who had tested negative forother viral infections. They found 79 (9 percent) who were positive forthe new virus, nine of whom were subsequently found to have evidence ofrecent infection with another virus as well. Of the remaining 67patients for whom clinical data were available, signs an...

Inexpensive, mass-produced genes core of synthetic biology advances at UH

...peuticagents, including vaccines for HIV and other viral diseases. Thistechnology also will facilitate development of new medications throughthe creation of humanized yet synthetic antibodies that could beespecially useful in detection and treatment of infectious organismsthat could be used by terrorists....

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

... too important for the successful treatment of HIV viral infection and control of AIDS. But hopefully our findings will save lives by alerting the physician to yet another side effect associated with this class of drug." Dr. Ackerman is director of Mayo Clinic's Long QT Syndrome Clinic and Sudden Death Ge...

Novel Enzyme Shows Potential As An Anti-HIV Target

... proteins, which play different roles in promoting viral infection and virulence. As a retrovirus, HIV uses...anscripts don’t reach full length and can’t effect viral replication. In a new study, Melanie Ott and colleagues identify an enzyme that regulates viral tran...

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

...w the innate immune system in mice's brains fights viral infection of neurons. The findings, published as t...at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brain. "Th...

Gene therapy converts dead bone graft to new, living tissue

...ive and ready to use ?is far harder than Schwarz's viral paste, which can be stored at room temperature and doesn't interfere with the normal grafting surgery. "We're very excited about the prospects of this technology," says Schwarz. "Our ultimate goal is to apply this to one of the Holy Grails of orthop...

Jefferson Virologists Coax HIV Out of Hiding

...dy. He suspectssuch strains may be from an unknown viral reservoir in the blood. “IL-7may teach us something,?he says. “We’re not sure why only thesecertain strains are affected. We think we’ve found a new population, anew reservoir of HIV that has not been seen before. It’s probably asub-population of blo...

Female sex hormones play a vital role in defense against sexually transmitted diseases

...n against primary exposure to sexually transmitted viral infections may be very different than those that may be useful in vaccination strategies," said Kaushic. "There is of course the flip side to this as well. Our studies in mice and in fact a number of clinical studies as well show that women who use ...

An HIV Protein Plays a Surprising Role in Gene Activation

...IV genome, is required for HIV gene activation and viral replication. It affects these processes, the curre... Tat binds to an area at the end of newly emerging viral RNA called the transactivation response element (TAR). Once bound, Tat recruits a cellular complex c...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...y to muscle. The investigators either injected the viral particles into the muscle or injected it intravenously in Pompe disease mice. Six weeks after muscular injection with the virus containing the muscle-restricted gene, mice exhibited high levels of the enzyme and reduced glycogen content in the injec...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...ne forthe HER2/neu protein in place of the deleted viral genes and thenpackaged the virus vector into virus-like replicon particles, referredto as “VRP-neu.?When these non-propagating particles are injected intoan animal, the vector directs the animal’s cells to make thousands ofcopies of the HER2/neu grow...

Scientists identify genetic pathways essential to RNA interference

...nts and animals and may help control resistance to viral infection, among other functions. For the current... RNAi that may underlie some cancers or be used in viral replication may offer further clinical potential. Along with Kim, the study's co-first authors are ...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

...ne forthe HER2/neu protein in place of the deleted viral genes and thenpackaged the virus vector into virus-like replicon particles, referredto as “VRP-neu.?When these non-propagating particles are injected intoan animal, the vector directs the animal’s cells to make thousands ofcopies of the HER2/neu grow...

Studies reveal methods viruses use to sidestep immune system

...urned on through RIG-I by the virus infection. The viral protease, NS3/4A, chops up essential signaling pro...atients with a protease inhibitor will prevent the viral protease from cutting up the signaling proteins," Dr. Gale said. "We're currently working to identif...

New SARS Protein Linked To Important Cell Doorway

...uman infections, to look for potentially important viral proteins. As reported recently in the journal Str...lp alert the immune system or to assist reproduced viral proteins as they make their way out of the cell. The finding exemplifies a primary directive of the...

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