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Tag: "vector" at biology news

Microbes hitchhike across Atlantic on desert dust

...te that transatlantic transport of dust could be a vector to renew reservoirs of some plant and animal pathogens in North America and could also be the cause of new diseases," says Griffin. ...

UF scientists restore sight to chickens with blinding disease

... a very fine glass needle, they injected the viral vector into the developing nervous system of a chicken embryo through a tiny hole in the eggshell. The shell was resealed and the egg was incubated to hatching to produce a live chick. "The process sounds straightforward but it really isn't," Semple-Rowlan...

Gene therapy injected into the brains' of mice with Huntington's disease

...on's disease and Alzheimer's disease patients. The vector is no longer a true virus as it cannot replicate o...n and no longer contains any of its own genes. The vector has been engineered to transfer the gene for the brain nutrient selectively to the area of the brain...

A new view on Lyme disease: Rodents hold the key to annual risk

... disease, like other zoonoses, is transmitted by a vector that picks up the pathogen during a blood meal from a vertebrate host. In the eastern and central United States, the spirochete bacterium Borrelia burgdorferi infects blacklegged ticks, Ixodes scapularis, which feed on a wide variety of birds, lizard...

Scientists discover new regulating mechanism in cells

...is-Lawrie and her collaborators were studying as a vector for gene therapy, was unable to make certain proteins. Thus, RHA might be a cellular target for future antiretroviral drugs. (Current antiretroviral drugs target the virus itself, which often becomes resistant to them, rendering the drugs ineffective...

Development of gene therapy

... of these genes. Gene transfer is achieved using a vector ? a kind of vehicle that carries the gene. Somatic gene transfer only targets body cells (somatic cells). Introducing genes into the germline is illegal in Germany. The first well-documented gene therapy studies were launched in the early 1990s. By 2...

Gene therapy for hereditary lung disease advances

...ers evaluated the safety of using a so-called gene vector - in this case an adeno-associated virus - to deli...er it was safe to give patients this gene transfer vector and then to try to begin to see if we could get the dose into a range where we would begin to replac...

Beyond the book: Software automates access to brain atlases

...cript program converting the files into a standard vector graphic (SVG) format. The SVG images are stored on the users system and organized using the software, which works on Linux, Windows and Macintosh operating system computers. The viewer software is open source and free, and can be downloaded from ...

Abnormal overexpression of p53 is a predictive molecular biomarker

...ted directly into tumors, which uses an adenoviral vector to deliver the wild type p53 gene to tumor cells. Results were presented at the first meeting on Molecular Diagnostics in Cancer Therapeutic Development, organized by the American Association for Cancer Research. "Not only do we now have a way to p...

Progress made in HIV vaccine development

...used recombinant adenovirus serotype 5 (rAd5) as a vector to deliver similar HIV strains. "Both approaches...d positive CD8 T cell responses. The recombinant vector vaccine was also well-tolerated, but higher doses led to some adverse events such as pain and fever....

Whitefly spreads emerging plant viruses

...emisia tabaci (B. tabaci), is the exclusive insect vector (transmitter) for a large group of emerging plant ... and fiber crops," Brown said. Early virus and vector detection, information about their distribution and host range, and knowledge about the mode of viru...

Experimental vaccine given during pregnancy reduces stillbirths from common virus

...hich are made from a whole killed virus. Called a vector vaccine, the experimental vaccine uses an altered ...the infection process. The virus used to make the vector vaccine (Venezuelan Equine Encephalitis Virus) was altered by removing 40 percent of the virus?genes...

Can engineered immune cells stop AIDS?

...recombinantly, this modified virus ?the lentiviral vector -- becomes a natural delivery system that can transport useful genes into cells without causing illness." Although the gene delivery technique looks promising, researchers are still working on ways to manipulate these elusive bone marrow cells and ...

Homing pigeons get their bearings from their beaks

...analyze the three components of the magnetic field vector separately. They react to the Earth’s external magnetic field in a very sensitive and specific manner, thus acting as a three-axis magnetometer. The study suggests that the birds sense the magnetic field independent of their motion and posture an...

Africa's first large-scale HIV vaccine study launches

...opulations with pre-existing immunity to the viral vector used in the vaccine, according to Corey, who is al...person to person. The adenovirus is the carrier or vector which transports copies of three HIV genes called gag, pol and nef. The vaccine is made in the labor...

30+ AIDS vaccine clinical trials in 24 countries, research occurring on every continent

...g Phase IIb test-of-concept trial with its adeno-5 vector vaccine candidate is expected in 2008 or 2009 and will provide preliminary information on the efficacy of this type of vaccine candidate. These results will have significant implications for the field's future research and development efforts. The co...

UCI scientists reconstruct migration of avian flu virus

...ost species in a region, regardless of the host or vector species it infects first. This way, the virus can find the right host to spread the infection to the next location. This parallel evolution ?the independent evolution of similar traits ?enables H5N1 to spread quickly, the scientists believe. "The ...

Genome of yellow fever/dengue fever mosquito sequenced

...uito resistant to the virus and stop its role as a vector for disease. Although that scenario is challenging, the payoff is potentially great, Tu said. "By introducing TEs in a more or less random way to see what happens to the laboratory mosquitoes, the TEs become a tool to study the genetic mechanism ...

First clinical trial of gene therapy for childhood blindness

... or "vector" to carry the gene into the cells. The vector has been manufactured for this trial by Targeted Genetics, Seattle, USA. Previous work using animal models has demonstrated that this gene therapy can improve and preserve vision. During trials, the vision of dogs with the defect was restored to ...

Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

... to deliver the same gene therapy with a different vector in the next phase of experiments. Kyrkanides is pa...ne can be delivered instead by an adeno-associated vector (AAV). AAVs have already been approved as safe for experimental gene therapy by the U.S. Food and Dr...

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