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Tag: "vector" at biology news

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

... I trial is the world's first study to use a viral vector (the non-pathogenic adeno-associated virus, or AAV...ical disease. In the Neurologix-funded trial, the vector was injected into a specific target site in the brain in order to transfer a gene to treat Parkinson...

Bird samples from Mongolia confirmed as H5N1 avian flu

...golia's paucity of domestic poultry suggests a new vector of avian flu. Finding the H5N1 strain during this expedition suggests that while the highly pathogenic avian influenza can be carried across long distances, the waterfowl species typically identified in recent outbreaks appear to be victims rather th...

Rensselaer researchers develop approach that predicts protein separation behavior

...pic steric mass action isotherm models and support vector machine regression computations. Biotechnology and Interdisciplinary Studies at Rensselaer At Rensselaer, faculty and students in diverse academic and research disciplines are collaborating at the intersection of the life sciences and engineerin...

Visceral Leishmaniasis: Successful Vaccine Trial In Dogs

...mania infantum. A flagellate protozoan, it uses as vector an insect resembling a midge, the sand fly, colonizing the intestine and then the salivary glands. The female insect feeds on mammals?blood. It can thus pass the parasite on to humans by a single bite. Once in the blood stream, L. infantum passes int...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...agrin gene to cells in two mouse models. The AAV-1 vector was given by systemic delivery ?a single infusion ...is study to transfer a therapeutic gene. The AAV-2 vector was delivered locally, given by intramuscular injection to different muscles of the leg. With both a...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

... United States. While the Pitt study used the same vector ?an inactivated virus that shuttles a gene into ce...the gene directly to affected tissue ?using as the vector an adeno-associated virus (AAV) instead of the vector used in the trial reported in PNAS. AAV appear...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...linical study in human patients soon. “We use the vector to provide targeted gene delivery to the nervous s...s studies, the researchers have confirmed that the vector remains in the dorsal root ganglion, but an enzyme expressed by the GAD gene moves to nerve terminal...

Breast tumors in mice eradicated using cancer vaccine

... on the idea of using Listeria as a cancer vaccine vector over ten years ago. "It took a while to dissect wh...isease than current chemotherapies." The Listeria vector is currently being prepared for a clinical trial targeting a tumor antigen associated with cervical ...

Mosquitoes are more attracted to individuals infected with malaria

...f manipulates the biting behaviour of the mosquito vector when it is ready for a new host. Such manipulation could have a profound effect on the epidemiology of disease and, if it is not considered, could lead to severe biases in the estimates of the intensity of malaria transmission. Citation: Lacroix R, ...

Scientists use gene transfer technology and common virus to block neuropathic pain

...linical study in human patients soon. "We use the vector to provide targeted gene delivery to the nervous s...s studies, the researchers have confirmed that the vector remains in the dorsal root ganglion, but an enzyme expressed by the GAD gene moves to nerve terminal...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...ta-sarcoglycan protein that was encoded by the AAV vector under the control of this promoter," he explained. In addition to Drs. Xiao and Zhu, other authors of this study are: Liqiao Zhou, V.M.D.; Zhong Wang, M.D., Ph.D.; Chunping Qiao, M.D., Ph.D.; Chunlian Chen, M.D.; and Juan Li, M.D., Molecular Therap...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...emoglobin that causes sickle cell disease, a viral vector was introduced in cell cultures of patients who have the disease. The vector carried a therapeutic globin gene harboring an embedded small interfering RNA precursor designed to ...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

...study to demonstrate successful delivery of a gene vector from a bare metal surface," said senior author Rob...at The Children's Hospital of Philadelphia. A gene vector is a biological substance, in this case an adenovirus, capable of delivering a therapeutic gene to t...

Swiss researchers develop all-in-one remote control gene expression tool

...ues and incorporated them into a single lentiviral vector ?a gene delivery system partly derived from HIV. W...n vivo ?the genetic material aboard the lentiviral vector joins the genetic material in the nucleus of the cell, causing the cell to express the protein encod...

New hybrid virus provides targeted molecular imaging of cancer

...ition to the obvious biological interest, when the vector is refined for patient use, it could perhaps help us diagnose, monitor and treat human tumors more accurately." The finding is the latest in a series of studies by Pasqualini and Arap that are built around their discovery that the human vasculature ...

Tool developed to silence genes in specific tissues using RNAi

..." he said. In their study, the researchers made a vector with a promoter specific for nurse cells in the testis, so that the small RNA that is associated with WT1 is only made in this cell type, thereby reducing WT1 levels that are only in the nurse cells. Other organs, like kidney, that need WT1 to functi...

Scientists force viruses to evolve as better delivery vehicles for gene therapy

...haracteristics of AAV to make it a better delivery vector for genes. "We think there are a huge variety of new problems we could address as well, such as targeting the virus to cells it is ordinarily not good at getting into, or speeding its transport through the body," he said. Though Schaffer acknowledg...

Genetically engineered mosquitoes show resistance to dengue fever virus

...lion people each year. Anthony James, a UC Irvine vector biologist, is one of a team of researchers who injected DNA into mosquito embryos, creating the first stable transgenic mosquito resistant to Type 2 dengue fever virus, the most prevalent strain of the disease. The mosquitoes that survived the proced...

Oxidation defense in mosquitoes benefits malaria parasite

...r this transforming of 3-HK into XA in the malaria vector Anopheles gambiae, where XA also helps the malarial parasite reproduce. So stopping the oxidative defense could stop the parasite as well as make the insect a victim of oxidative stress. Rizzi's group at the University of Piemonte Orientale focuses ...

UF scientists test improved gene therapy method for hereditary heart conditions

...re is that we can deliver a much lower dose of the vector into a vein like any other drug, and the corrective gene collects in the heart." Scientists say gene therapy looks increasingly feasible for the treatment of cardiovascular conditions linked to faulty genes or congenital metabolic diseases, includi...

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