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Tag: "vector" at biology news

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...theVEE virus, thereby making it impossible for the vector version of virusto reproduce itself, but still allowing the vector to express thetarget protein. For this study, the researchers inserted the gene forthe HER2/neu prot...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

...theVEE virus, thereby making it impossible for the vector version of virusto reproduce itself, but still allowing the vector to express thetarget protein. For this study, the researchers inserted the gene forthe HER2/neu prot...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...ndel has been working on the idea of introducing a vector into brain that would express GDNF. What they've found is that if you get low-level expression, you can prevent cell death in a part of the brain called the substantia nigra. That's been shown before in rodent models, but it's encouraging to see data...

Scientists reveal molecular secrets of the malaria parasite

...ge during whichthe parasite is transmitted between vector and host.The Science paper represents the culmination of four years ofcooperative work by scientists at several research institutes,including: the Wellcome Trust Sanger Institute in the U.K., where thesequencing and genome annotation was performed on...

Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

...e for the MRI reporter. They used a widely studied vector called a replication-defective adenovirus that rea... but doesn't reproduce itself. Ahrens injected the vector carrying the MRI reporter gene into brains of living mice and imaged the MRI reporter expression per...

Gene therapy for Parkinson's disease moves forward in animals

...ndel has been working on the idea of introducing a vector into brain that would express GDNF. What they've found is that if you get low-level expression, you can prevent cell death in a part of the brain called the substantia nigra. That's been shown before in rodent models, but it's encouraging to see data...

WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas

...so making accessible insecticide-treated bed-nets, vector control supplies, and equipment for larviciding an... being implemented, including the strengthening of vector surveillance measures, while family-sized insecticide impregnated bed-nets have been distributed to ...

Gene Therapy Cures Inherited Liver Disease In Rats

...lack of genes in this area of the cell. The viral vector itself is important because it has no long term ef... treatment can be tried in humans. While the viral vector is fairly benign long term, he would like to see one developed that minimizes the body's immune resp...

Researchers identify protein crucial for survival of Lyme-disease bacterium

...it has chosen a tick environment to be its natural vector in nature. "It potentially could give us a target for eradicating the bacterium, because if you understand what it needs to sustain itself, then in theory you could disrupt that cycle by blocking whatever that mechanism is," Dr. Norgard said. Tradi...

Turning viruses into allies against cancer

...tential of this modified virus to serve as a novel vector for cancer gene therapy of hepatocellular carcinoma," said Boris Blechacz, M.D., a research fellow in the Molecular Medicine Program at the Mayo Clinic and the study's lead investigator. Liver cancer is one of the leading causes of cancer death worl...

Gene therapy cures inherited liver disease in rats

...lack of genes in this area of the cell. The viral vector itself is important because it has no long term ef... treatment can be tried in humans. While the viral vector is fairly benign long term, he would like to see one developed that minimizes the body's immune resp...

Building a protein name dictionary from full text: a machine learning term extraction approach

...gh frequency terms in an article, and uses support vector machines (SVM) to identify biological entity names. It is also computationally efficient and robust to noise commonly found in full text material. We use the method to create a protein name dictionary from a set of 80,528 full text articles. Only 8.3...

Internet viruses help ecologists control invasive species

..., Muirhead and MacIsaac examined patterns of human vector movement to see whether some invaded systems have ...etwork where they will have most impact. "Outbound vector traffic from hubs with large flows to non-invaded destinations should be targeted for management eff...

'EuroVacc 02' HIV Vaccine Trial Begins

...nsporters" (vectors). A first dose of antigen A in vector X is administered, followed by a booster using the same antigen A in vector Y this time. In this way, immune reactions to, and the consequent inhibition of the transporter are ...

Aircraft Cabin Ventilation Influences The Transmission Of Diseases In-flight

...ft - spraying before landing to kill insects - and vector control around airports, as well as immunisation, seem to have been effective in non-endemic areas. However, although International Health regulations recommend disinsecting aircraft travelling from countries with malaria and other vector-borne disea...

New vaccine means bye-bye to bacteria in the lung

...ginosa. The researchers use a modified adenovirus vector vaccine expressing a region of the outer membrane of P. aeruginosa, called OprF, which had previously been recognized as a promising vaccine candidate. This region of the bacteria was expressed in the capsid area of the vector. Immunization of mice w...

Using nanoparticles, in vivo gene therapy activates brain stem cells

...in vivo. "This is the first time that a non-viral vector has demonstrated efficacy in vivo at levels comparable to a viral vector," Bharali said. In the UB experiments, targeted dopamine neurons -- which degenerate in Parkinson's disease, for example -- took up and expressed a fluorescent marker gene, dem...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...und that one dose of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal said. "If the HO-1 pathway is blocked, the protective effects of IL-10 are lost. The delay in vascular disease shown in this study could ?after more research and possible clinical trials in human b...

Gene therapy advance treats hemophilia in mouse models

...d Lucille A. Carver College of Medicine improved a vector -- a vehicle that delivers gene therapy to cells -...now is studying additional ways to make the hybrid vector express the protein even better. ...

Gene therapy to lower blood pressure just enough

...of ANP a cell makes was needed. The special viral vector developed by O'Malley and his colleagues combines ... body will accept repeated injections of the viral vector or whether its immune system eventually react against it, said O'Malley. ...

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