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Tag: "vascular" at biology news

Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation

...searchers are studying the possibility of treating vascular inflammation and plaque buildup through the transf...s of protective effect against atherosclerosis and vascular inflammation, which are tied together," said Prediman K. Shah, M.D., director of the Division of Car...

Cell wall of pneumonia bacteria can cause brain and heart damage

...that pieces of the bacterial cell wall bind to the vascular endothelium (inner surface of the blood vessel) by hooking onto a protein called platelet activating factor receptor (PAFr). Platelet activating factor (PAF) is an immune system signaling molecule that activates certain white blood cells. It normally...

A new jump start for aging blood vessels

...nt studies show promise for significantly reducing vascular aging by inactivating TNFa, which has been linked ...of The American Journal of Pathology. Age-related vascular diseases, including high blood pressure, heart attack and stroke, occur naturally, even in otherwise...

U of MN researchers find novel genes critical in organ development

... Zebrafish are a good model for studying how the vascular system develops. They study genes that are "conserved" between zebrafish and humans. This means the genes exist and have the same function in both zebrafish and humans....

How blood flow dictates gene expression

...mal adult blood vessels and in the pathogenesis of vascular diseases, such as atherosclerosis. ...

Long-term cancer risk follows stem cell transplant recipients

...effects, such as mucostitis, infections, and liver vascular obstruction as well as the potential long-term complication of developing of a second, usually solid cancer. To estimate the risk and identify risk factors associated with this outcome, Genevieve Gallagher, M.D. and Donna L. Forrest, M.D. of the B...

Getting to the heart of the heart

...rically conductive tissue of the heart, and to the vascular smooth muscle cells that line the heart's blood vessels. This cell is responsible for the formation of the left-sided chambers of the heart, the first chambers to form in the embryo. Working in parallel, a separate team at Massachusetts General Hos...

Therapeutic role found for carbon monoxide

...CO's successful track record in helping to prevent vascular disease, Otterbein and first author Brian Zuckerbraun, MD, of the University of Pittsburgh, hypothesized that the gas might prove beneficial in treating pulmonary arterial hypertension. To test this hypothesis, the scientists first exposed a PAH mou...

A fisheye view of the deadliest breast cancer

... of two potential anticancer compounds at work: a vascular endothelial growth factor (VEGF) receptor inhibitor called SU5416, and a protein kinase inhibitor called PP1. Analysis of compound and mock-treated animals revealed that SU5416 leads to shrinkage of tumor cells and tumor-induced vasculature, while ...

'Trojan Horse' agent halts bone metastasis in mice

A novel vascular targeting agent completely prevented the developme...so revealed critical information about the role of vascular endothelial growth factor (VEGF) in the development of tumors in bone, says Rosenblum. VEGF is a sig...

Drug can quickly mobilize an army of cells to repair injury

...lls may also help improve blood flow in peripheral vascular disease, a problem often encountered in diabetic p...al trial to test G-CSF in patients with peripheral vascular disease," Link says. "We chose G-CSF in this case because it's not essential that the treatment act ...

A new approach to growing heart muscle

..., tri-leaflet valves, cell-based cardiac pumps and vascular grafts. In addition, the laboratory has expertise in several different tissue engineering platforms: self-organization strategies, biodegradable hydrogels such as fibrin, and polymeric scaffolds. Each approach may turn out to have its own applicat...

First Quantum Grant to fund stem cell repair of damage from stroke

...ients where it will provide a source of neural and vascular cells that will continue to develop and differenti...eas of expertise in developmental neurobiology and vascular biology, stem cell biology, genetics, biomedical imaging, tissue engineering, and clinical cellular ...

Molecules in blood foretell development of preeclampsia

...n the lining of blood vessels. Another substance, vascular endothelial growth factor (VEGF) also binds to Flt1. This binding process is essential to keeping blood vessels healthy and maintaining normal blood pressure. Similarly, a molecule known as transforming growth factor beta (TGF beta) binds to endogl...

Heart smart: new drug improves blood flow

..."In up to 95 per cent of cases, the root causes of vascular diseases are still unknown. So clinicians have to ...heart attacks and strokes. We need a revolution in vascular diagnosis, treatment and prevention. This discovery is an important step along the way." ...

Plant studies reveal how, where seeds store iron

...e team found that iron is stored in the developing vascular system of the seed of Arabidopsis, a model plant used in research. In particular, iron is stored in the vacuole, a plant cell's central storage site. The researchers also learned this localization depends on a protein called VIT1, known to transport ...

Plant studies reveal how, where seeds store iron

...e team found that iron is stored in the developing vascular system of the seed of Arabidopsis, a model plant used in research. In particular, iron is stored in the vacuole, a plant cell's central storage site. The researchers also learned this localization depends on a protein called VIT1, known to transport ...

Stress hormones may play new role in speeding up cancer growth

...order to maintain their shape. The third compound, vascular endothelial growth factor (VEGF), is important in the growth of new blood vessels into tumor cells. Earlier work by researcher Anil Sood at the University of Texas had shown that the same stress hormones can stimulate ovarian tumor cells to produc...

New imaging technique tracks traffic patterns of white blood cells

...cell subsets and their forming microdomains in the vascular system in real time. In the upcoming March issue ...evel but there is still no treatment for the acute vascular occlusions which are the hallmark of the disease," said Mount Sinai researcher Dr. Paul S. Frenette....

Nanoparticles can track cells deep within living organisms

...hat makes the labeled cells potentially useful for vascular research as well. "Many kinds of cells are involved in the formation of new blood vessels," Partlow says. "Because we can create a separate MRI signature for different cells with these various types of unique nanoparticles, we could use them to bette...

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