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Tag: "vascular" at biology news

Association of herpesvirus with lung disorder questioned

...pulmonary hypertension is characterized in part by vascular lesions in the lung, and may lead to heart failure. Some cases are associated with genetic susceptibility, the investigators noted, but the pathogenesis of most cases is not known. Dr. Katano and colleagues conducted their research using a design si...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...ies of their legs --a condition called peripheral vascular disease (PVD). Individuals with PVD have decreased... constrictduring exercise. In some individuals the vascular system corrects theproblem on its own either by forming new blood vessels, called"collaterals," that...

FDA Approves New Drug to Treat Type I and Type II Diabetes

... disease, including blindness, kidney disease, and vascular disease. Symlin is to be used only in combination with insulin to help lower blood sugar during the 3 hours after meals. Symlin will have a Medication Guide (FDA-approved patient labeling) and a Risk Minimization Action Plan (RiskMAP) due to three a...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

... heart. The phase II clinical research study uses vascular endothelial growth factor-2 (VEGF-2) in the form of a solution containing a DNA plasmid that is delivered using catheterization to heart tissue that has been damaged from insufficient blood flow. Once the catheter reaches the targeted site inside of...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...sible obstruction of blood vessels. Relieving the vascular constriction and resulting oxygen deficiency through the restoration of nitric oxide to red cell membranes might therefore prevent the disease symptoms, opening up a new realm of therapeutic possibilities, Stamler said. Current therapies fail to trea...

Biodiversity hotspots identify conservation priorities

...analysis shows that an estimated 50 percent of all vascular plants and 42 percent of terrestrial vertebrates e... at least half a percent of the total diversity of vascular plants as endemics; this translates to 1,500 species of vascular plants found exclusively within its...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...pression. "eNOS is found almost exclusively in the vascular endothelium and the NO that it synthesizes plays a...tion, the reactivity of immune cells and growth of vascular smooth muscle cells," explains Dr. Hobbs. "iNOS is not expressed under normal physiological conditio...

Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes

... study (the GENIC study) to try to determine which vascular or genetic factors contribute to the syndrome. They will also attempt to replicate their MRI data in an autopsy study of patients who died with dolichoectasia. ### Article: "Intracranial Arterial Dolichoectasia and Small-Vessel Disease in Stroke Pa...

Nano-bumps could help repair clogged blood vessels

...e kind of increased attachment for endothelial and vascular smooth muscle cells lining the insides of arteries, said Thomas Webster, an associate professor of biomedical engineering at Purdue. The stents are small metal scaffolds that are inserted inside arteries to prop them open during or after surgery to ...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...h chemotherapy, is designed to bind to and inhibit vascular endothelial growth factor (VEGF). VEGF is a protein that plays a critical role in tumor angiogenesis. “It is noteworthy that a previous company-sponsored trial in patients who received prior chemotherapy for advanced disease did not show a benefit w...

Next Generation Body Scanner Launched By The University Of Manchester

...urrently underway at the University to investigate vascular abnormalities to the kidneys in patients with renal disease. The scanner, which has been manufactured by Philips Medical Systems and features a 5.5 tonne magnet, will be launched by Professor Colin Blakemore, Chief Executive of the Medical Research ...

Scientists identify genes responsible for 'black rot' disease in vegetables

...s vegetable crops by spreading through the plants' vascular tissues, turning the veins in their leaves yellow and black, and causing V-shaped lesions along the margins of the leaves. All vegetables in the crucifer family, including broccoli, Brussels sprouts, cabbage, cauliflower, kale, mustard, radish, rutab...

Natural Killers Could Lead to New Hepatitis Treatments

...s waste products from the blood. Inside the liver, vascular passages, or “sinusoids,?are filled with a witches' brew of nutrients, toxins, proteins, lipids and other chemicals. Thus, immune guardians that patrol the liver must tolerate many foreign molecules, yet respond readily to infection. “It wasn't clea...

Engineers improve plastic's potential for use in implants by linking it to biological material

... other molecules in the future, possibly including vascular endothelial growth factor, which stimulates the growth of new blood vessels. In addition, they will use the bacteriophage analysis approach, called high-throughput combinatorial screening, to look for peptide linkers for other plastics such as polygl...

MIT engineers an anti-cancer smart bomb

...for attacking the two compartments of a tumor, its vascular system and the cancer cells," said Judah Folkman of Children's Hospital Boston. "This is a very neat approach to drug delivery," said MIT Institute Professor Robert Langer. The nanocell worked better against melanoma than lung cancer, indicating the...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...ties that help keep blood vessels healthy. Chronic vascular rejection, characterized by thickening of the inte...of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal said. "If the HO-1 pathway is blocked, the protective effects of IL...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...side part of a blood vessel, together to bind with vascular smooth muscle, the outer portion of a blood vessel.... Blood vessels only work when both endothelia and vascular smooth muscle are bound together. Previous work on integrin alpha4beta1 showed that the protein work...

Going To Extremes To Improve Human Health

...chamber allows us to monitor minute changes in the vascular and respiratory systems of subjects both at rest a...ch as diabetes, involves uncovering the neural and vascular interactions in the skin during environmental heat stress. In the effort to understand why young wom...

New lead reported in tumor angiogenesis

...inhibit secreted proteins such as the much-studied vascular endothelial growth factor, or VEGF, which clearly plays a role in tumor angiogenesis," said Wang. "To date, though, none of these compounds have been very effective as cancer therapies, suggesting that other factors may play a role. We think that we ...

Discovery of T-cell 'traffic control' boosts new drug promise

...n both the immune system and the blood-circulating vascular system, showing how the two systems interact to regulate T cell circulation and prevent a constant and potentially dangerous release of T cells, or lymphocytes. The research is presented this month in a special issue of Nature Reviews Immunology. Au...

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