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Tag: "variants" at biology news

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...atment of cancer than ever before." Xencor's Fc variants were engineered using the company's XmAb TM techn...search to generate a suite of patented Fc antibody variants that have optimized antibody-Fc receptor affinity, which translate into increased effector functions...

Evolution follows few of the possible paths to antibiotic resistance

...t very many distinct mutational paths link any two variants of a gene," says lead author Daniel M. Weinreich, a research associate in Harvard's Department of Organismic and Evolutionary Biology. "Although this fact has been recognized for at least 35 years, its implications for evolution by natural selection ...

Variation in bitter-taste receptor gene increases risk for alcoholism

...r of individuals, but they didn't identify genetic variants they hadn't found already in the public databases. The variant that increases risk of alcohol dependence was common in African Americans -- where about 45 percent of those studied carried this variation in the TAS2R16 receptor gene -- but rare in Ca...

Research updates 65-year-old genetic discovery

Gene variants determine which humans and which chimpanzees can t...onclude that both humans and chimpanzees have gene variants but for different reasons--and is an example of convergent evolution. It was only a few years ago, ...

Outsmarting the smartie bug

...of this organism. Our work in describing all known variants will help in that surveillance" Two vaccines are available. The first, PCV, recognizes seven forms of the capsule and protects against 82% of infections in children under five years of age in the UK. This will soon be given to UK children under th...

Two NIH initiatives launch intensive efforts to find roots of common diseases

...nges is challenging. Finding these disease-causing variants is one of the highest priorities of current biomed...rge numbers of patients for such a large number of variants would be prohibitively expensive. Fortunately, a major shortcut has been discovered that reduces the...

Rare Chinese frogs communicate by means of ultrasonic sound

...e thesehigh-pitched bird-like calls, with numerous variants in terms of harmonics and frequency sweeps. Some sounds exceeded their recording device's maximum capability of 128 kilohertz. Human ears hear sound waves generally no higher than 20 kilohertz. The frogs studied inhabit Huangshan Hot Springs, a popul...

Utah researchers confirm chromosome may harbor autism gene

... an extremely fine scale. The chance of the same variants of SNPs in a particular region on a chromosome being passed through several generations from a founding couple to multiple affected family members is slight. When such identical blocks of SNPs are found, the chromosomal region often is a good candida...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

.... The polypeptide backbone of each of the antibody variants produced in the GlycoFi yeast remained identical a... antibody was altered. Comparisons of the antibody variants with Rituxan® showed that antibody binding varied with changes in the glycosylation structure. Moreo...

Natural selection at single gene demonstrated

... behavior of the plants," Toomajian said. Why the variants were selected remains unclear, though some have su...griculture. Toomajian's group identified the gene variants through a comparison of 96 plants over 1,102 short fragments of the genome. Each variant was assign...

Fruit fly's beating heart helps identify human heart disease genes

...reen genes to identify potential gene mutations or variants implicated in human heart disease. The achievement also raises the possible of rapid screening in fruit flies of drugs to treat heart disease, said the researchers. The team's bioengineers adapted an existing imaging technology to visualize in detai...

Researchers map of genetic variations implicated in disease

...udy further described over 300 amino acid changing variants in gene sequences. These variants are strong candidates for functional studies to understand the role of variation in MHC-associated d...

Cortex matures faster in youth with highest IQ

...esearchers are following-up with a search for gene variants that might be linked to the newly discovered trajectories. However, Shaw notes mounting evidence suggesting that the effects of genes often depends on interactions with environmental events, so the determinants of intelligence will likely prove to be...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

...entire human genome and identify genes with common variants that contribute to complex diseases, researchers a...bute to QT length. Now that researchers know that variants of the NOS1AP gene correlate with QT interval length, they hope to figure out exactly how the DNA se...

New research examines genetics of successful aging

...compared to the group of young adults. These gene variants confer protection and risk, respectively, of Alzheimer's disease, the most common cause of dementia in late life. The study also identified novel genetic regions associated with successful aging, including DYS389 and DYS390, some of which affected m...

Scientist uses form to explain function of key building blocks of life

...ne the strength of hydrogen bonds in ten different variants of the protein. From that data, the team was able to explain changes in protein function. "In science, you try to build theories that will explain the properties of the systems you are looking at," explains Markley. "Proteins are the basic building...

Scientists pinpoint inflammation gene

...his information and predict which of these genetic variants was most likely to have a direct effect on inflamm...lysis to eliminate scientific "guesswork" on which variants ought to be investigated in the laboratory. The statistical analysis identified one particular vari...

First big influenza genome study reveals flu evolution

... period. In some of the flu seasons studied, these variants circulated simultaneously. That means New Yorkers ...ic influenza virus showed striking diversity, with variants frequently swapping genetic material. In fact, the researchers report, one such event explains why ...

Cornell finds natural selection in humans

...al of the project was to identify novel amino acid variants that could then be tested for association with human disease in subsequent studies. The Cornell researchers became involved at the analysis stage in order to make predictions about what types of changes are most likely to be functionally important. ...

Housecat-sized Siberian tiger cubs get collared

...s potential reproductive success based on sequence variants of the LHB/CGB genes," explains Laan. "We may b...ons and to minimize attention on the innocent gene variants that colour the humanity of life." Contact: Lon R. Cardon, Ph.D. Professor of Bioinformat...

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