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Tag: "variants" at biology news

St. Jude test of bird flu vaccine proves successful

...ch a vaccine would protect humans against multiple variants of the bird and human influenza viruses, according...trigger an immune defense against a broad range of variants of the virus. "Even if the bird flu virus mutates so it becomes adapted to humans, this kind of cro...

Tamed 11,400 years ago, figs were likely first domesticated crop

...d the ancient figs to modern wild and domesticated variants and determined that they were a mutant selectively propagated by humans. In this variety of fig, known as parthenocarpic, the fruit develops without insect pollination and is prevented from falling off the tree, allowing it to become soft, sweet, and...

Control measures fail to stop spread of new H5N1 virus

...ged in late 2005 and replaced most of the previous variants across a large part of southern China, despite an ... viruses and their success in replacing other H5N1 variants in such a short time demonstrates how difficult it is to control H5N1 in China, Webster said. ...

Gene linked to rare disease activates fat breakdown

...ng its activity up to 20-fold. In contrast, CGI-58 variants with the mutations found in patients with CDS fail to activate ATGL, they found. Moreover, the joint expression of CGI-58 and ATGL limits lipid accumulation in cultured cells, while treatments that block CGI-58 in fat cells inhibit the removal of sto...

Large-scale genomics project will hunt genes behind common childhood diseases

...head, said Dr. Hakonarson, is not only to map gene variants to disease risk, but also to investigate how genes...ay and simultaneously analyze over 550,000 genetic variants for each sample. Developed by San Diego-based Illumina, the genotyping BeadLab will be installed and...

Variations in detoxifying genes linked to Lou Gehrig's disease

... individuals as a possible cause. PON gene cluster variants have previously been associated with other neurodegenerative and vascular disorders, including Alzheimer's disease, Parkinson's disease, coronary artery disease and stroke. Although the Northwestern DNA study samples were not analyzed for inclusion...

DNA to the defense

..., some trypanosomes rapidly evolve and express new variants of VSG, thereby allowing the parasite to persist and spread through a population. In the current study, Sergio Callejas, a Marie Curie Research Fellow in Melville's laboratory and the first author on the manuscript, conducted a series of experimen...

A sweet solution for Alzheimer's disease?

Certain variants of a simple sugar ameliorate Alzheimer's-like disease in mice, according to a new study by Canadian researchers. Although the new studies are still in the early stages, the findings could lead to new therapies that prevent or delay the onset of Alzhe...

Experimental vaccine protects lab animals against several strains of H5N1

...d need, as it would protect against newly emerging variants until a strain-specific vaccine can be developed. The reverse genetics method used by the St. Jude investigators would allow rapid vaccine preparation, which is crucial in a potentially fast-moving pandemic. Other undertaken vaccine approaches have s...

HIV-1's high virulence might be an accident of evolution

...current study, Kirchhoff's group examined nef gene variants taken from a variety of divergent SIV lineages. Nef variants from the great majority of primate SIVs, including the less virulent human strain HIV-2, suppress th...

Chimpanzee study reveals genome variation hotspots

... "We found that chimpanzees have many copy number variants -- duplications or deletions of large segments of ... the study's lead author, says: "These copy number variants may be very significant from an evolutionary perspective, and they're important to study and underst...

Ready, set, mutate?and may the best microbe win

...e strains, each of which contained one of just six variants of the critical gene. The first of the six, dubbed Q199R, arose almost immediately, and was the dominant strain through the 500th generation. Around 62 degrees Celsius, the Q199R was unable to further cope with the rising temperature, and a new roun...

Scientists to employ Arctic ice and polar bears to protect diversity of world's crops

...uenza virus H5N1 may protect humans against future variants of the virus. Vaccines based on this model might t... show cross-reactive immunity against current H5N1 variants in ferrets, according to Robert Webster, Ph.D., a member of the Infectious Diseases department and h...

H5N1 vaccine could be basis for life-saving stockpile

...uenza virus H5N1 may protect humans against future variants of the virus. Vaccines based on this model might t... show cross-reactive immunity against current H5N1 variants in ferrets, according to Robert Webster, Ph.D., a member of the Infectious Diseases department and h...

NHGRI announces latest sequencing targets

...in sex-linked diseases; and to survey the range of variants in genes known to contribute to some common diseases. ...

Viral genetic differences are possible key to HIV dementia

...ually try to design a drug to target these genetic variants that are responsible for the neurological damage." Pillai notes that the issue of HIV dementia is particularly important in regions outside North America and Europe where state-of-the-art antiretroviral medications are not widely available and HIV ...

Life, the remake

...ily swapped genes, as bacteria still do today. Any variants or competitors to the genetic code that arose later would have been unable to spread and establish. Vermeij thinks that these principles are universal. "If we had an Earth-like planet, I think we'd see phenotypes and outcomes that parallel those on...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...f Public Health and her colleagues looked at seven variants of the gene for alpha-methylacyl-CoA racemase, or ... no one had examined the association between AMACR variants and colorectal adenomas or cancer. The research team identified 725 white men and women between age...

History of human cannibalism eats away at researchers

...ed 28 different haplotypes ?or combinations of DNA variants ?in the PRNP gene and used this data to assess the ages of the mutations, to identify geographic patterns of variation, and to evaluate selective forces that have potentially influenced these patterns. "In contrast to the previous study, which con...

Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher

...85 dancers and advanced dancing students in Israel variants of two genes that provide the code for the serotonin transporter and arginine vasopressin receptor 1a. Both genes are involved in the transmission of information between nerve cells. The serotonin transporter regulates the level of serotonin, a bra...

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